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Activated coagulation and ibd: noise or music?
Publication Year: 1996 Source: Inflamm Bowel Dis PMID: 23282604 DOI: 10.1097/00054725-199612000-00018
BACKGROUND: Many treatment options exist for children with inflammatory bowel disease (IBD), yet the lack of clinical guidelines for management has lead to great variation in care. The purpose of this project was to evaluate current treatment modalities in children from the Northeast US who applied to the 2010 session …
Will the rapidly metabolized steroids revolutionize ibd therapy?
Publication Year: 1995 Source: Inflamm Bowel Dis PMID: 23282311 DOI: 10.1097/00054725-199506000-00012
Many identified and yet unknown factors contribute to the pathogenesis of inflammatory bowel disease (IBD). The genome-wide association studies clearly support the earlier developed concept that IBD occurs in genetically predisposed individuals who are exposed to distinct environmental factors, which together result in dysregulation of the mucosal immune system. Thus, …
Radiology Versus Colonoscopy in Evaluation of Colonic IBD
Publication Year: 1995 Source: Inflamm Bowel Dis PMID: 23282396 DOI: 10.1097/00054725-199509000-00011
Peroxisome proliferator-activated receptor-γ (PPAR-γ) is widely expressed in macrophages and has been identified as a putative target for the development of novel therapies against inflammatory bowel disease (IBD). Computational simulations identified macrophages as key targets for therapeutic interventions against IBD. This study aimed to characterize the mechanisms underlying the beneficial …
Sound of water in ibd
Publication Year: 1995 Source: Inflamm Bowel Dis PMID: 23282398 DOI: 10.1097/00054725-199509000-00013
BACKGROUND & AIMS: Inducible heat shock proteins (iHsp), Hsp25/27 and Hsp70, play essential roles in protecting cells against stress and, in intestinal mucosal inflammation, potentially lessening the extent and severity of injury. We examined the expression and regulation of iHsp in human and experimental inflammatory bowel diseases (IBD) and in …
Standards for Approval of New Drugs for IBD
Publication Year: 1995 Source: Inflamm Bowel Dis PMID: 23282428 DOI: 10.1097/00054725-199512000-00007
6-Mercaptopurine and its prodrug azathioprine remain the mainstay of immunomodulator therapy for the maintenance of a steroid-free remission in patients with IBD. Recent evidence suggests that the cytotoxic and immunosuppressive effects of azathioprine might be mediated via the induction of lymphocyte apoptosis by its active metabolites, 6-thioguanine nucleotides. The therapeutic …
Mechanisms of growth retardation, drug therapy, and nutritional support in pediatric inflammatory bowel disease: a workshop sponsored by the north american and European societies for pediatric gastroenterology and nutrition
Publication Year: 1995 Source: Inflamm Bowel Dis PMID: 23282433 DOI: 10.1097/00054725-199512000-00012
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Addressing lymphocytes for mucosal delivery in ibd
Publication Year: 1995 Source: Inflamm Bowel Dis PMID: 23282439 DOI: 10.1097/00054725-199512000-00018
Vitamin deficiencies are common in patients with inflammatory bowel disease (IBD). Homocysteine (Hcys) is a thrombogenic amino acid produced from methionine (Met), and its increase in patients with IBD indicates a disruption of Met metabolism; however, the role of Hcys and Met metabolism in IBD is not well understood. We …
Alexithymia in inflammatory bowel disease. A case-control study
Publication Year: 1995 Source: Psychother Psychosom PMID: 7480583 DOI: 10.1159/000288990
The significance of interleukin-6 (IL-6) in patients with inflammatory bowel disease (IBD) was studied by measuring the IL-6 level in serum and colonic tissue by means of an enzyme-linked immunosorbent assay (ELISA), and by examining its localization using an immunohistochemical method. The serum IL-6 level reflected the degree of disease …
Subclinical time span of inflammatory bowel disease in patients with primary sclerosing cholangitis
Publication Year: 1995 Source: Dis Colon Rectum PMID: 7497843 DOI: 10.1007/BF02049156
OBJECTIVE: Despite the use of immunosuppressive drugs, recurrent and de novo inflammatory bowel disease (IBD) can develop after orthotopic liver transplantation (OLT). Cytomegalovirus (CMV) infection has been suggested to play a role in the pathogenesis of IBD. The aim of this study was to investigate the role of CMV infection …
Simultaneous administration of 111In-human immunoglobulin and 99mTc-HMPAO labelled leucocytes in inflammatory bowel disease
Publication Year: 1995 Source: Eur J Nucl Med PMID: 7498228 DOI: 10.1007/BF01254568
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