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Genetic and molecular analysis of terminal deletions of chromosome 3R of Drosophila melanogaster
Publication Year: 1995 Source: Gene PMID: 7890161 DOI: 10.1016/0378-1119(94)00831-c
Crohn's disease (CD) has usually been managed in an escalation manner, introducing more powerful (and toxic) drugs only once those with a better safety profile had failed. However, the natural history of CD under conventional therapeutic strategies results in high intestinal resection requirements and high rates of clinical relapse and …
Expression of growth factor receptor-encoded mRNA by colonic epithelial cells is altered in inflammatory bowel disease
Publication Year: 1995 Source: Dig Dis Sci PMID: 7895532 DOI: 10.1007/BF02064355
BACKGROUND: Capsule endoscopy (CE) is performed to assess inflammatory bowel disease (IBD). We aimed to define the results of CE in subtypes of IBD and to determine whether CE results in management changes. METHODS: A retrospective cohort study was performed of all CEs for IBD at a tertiary care center …
Neurologic aspects of inflammatory bowel disease
Publication Year: 1995 Source: Neurology PMID: 7898687 DOI: 10.1212/wnl.45.3.416
OBJECTIVE: To analyze and discuss the deafness of Ludwig van Beethoven (1770-1827) and to offer a logical theory for its etiology. METHOD: The study will carefully review the composer's symptoms as described in his letters to friends and acquaintances and also will review a large body of source material, particularly …
Efficacy of subcutaneous application of live infectious bursal disease vaccine in young chickens with maternally derived antibody
Publication Year: 1995 Source: J Vet Med Sci PMID: 8519892 DOI: 10.1292/jvms.57.647
The efficacy of zileuton, a new 5-lipoxygenase inhibitor, was investigated in comparison with sulphasalazine in an experimental model of rat colitis. Under light anaesthesia with ether, male rats were subjected to intracolonic administration of trinitrobenzene sulfonic acid (TNB) in 50% ethanol and were then sacrificed 2, 4 and 7 days …
Direct evidence of monocyte recruitment to inflammatory bowel disease mucosa
Publication Year: 1995 Source: J Gastroenterol Hepatol PMID: 8527703 DOI: 10.1111/j.1440-1746.1995.tb01589.x
BACKGROUND: Growth failure frequently complicates the clinical course of inflammatory bowel disease (IBD) in children. This study was designed to investigate the role of disease activity versus steroid therapy on growth faltering in this disorder. METHODS: We studied growth failure and its relationship to disease activity and steroid therapy in …
Breakdown of tolerance to the intestinal bacterial flora in inflammatory bowel disease (IBD)
Publication Year: 1995 Source: Clin Exp Immunol PMID: 8536355 DOI: 10.1111/j.1365-2249.1995.tb03835.x
BACKGROUND: Anemia is an important complication of inflammatory bowel disease (IBD). Recent data suggest that hepcidin is a major mediator of anemia with a central role in iron homeostasis and metabolism. The aim of this study was to evaluate the serum levels of hepcidin and its prohormone, prohepcidin, in patients …
Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD)
Publication Year: 1995 Source: Clin Exp Immunol PMID: 8536356 DOI: 10.1111/j.1365-2249.1995.tb03836.x
Intestinal secretions may be obtained by gut lavage using a polyethyleneglycol-based electrolyte lavage solution; concentrations of immunoglobulins and other proteins are readily measured in processed gut lavage fluid. As patients with inflammatory bowel disease (IBD) have greatly increased numbers of IgG-producing intestinal immunocytes, we measured gut lavage fluid IgG levels …
Peripheral cell-mediated immune response to mycobacterial antigens in inflammatory bowel disease
Publication Year: 1995 Source: Clin Exp Immunol PMID: 8536357 DOI: 10.1111/j.1365-2249.1995.tb03837.x
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Pharmacological activity of the second generation leukotriene B4 receptor antagonist, SC-53228: effects on acute colonic inflammation and hepatic function in rodents
Publication Year: 1995 Source: Inflammation PMID: 8543366 DOI: 10.1007/BF01539131
Comment in J Pediatr Gastroenterol Nutr. 2011 Nov;53(5):473. BACKGROUND: Inflammatory bowel diseases (IBDs) are costly chronic gastrointestinal diseases, with pediatric IBD representing increased costs per patient compared to adult disease. Health care expenditures for ulcerative colitis (UC) are >$2 billion annually. It is not clear whether the addition of VSL#3 …
Increased frequency of bronchial hyperresponsiveness in patients with inflammatory bowel disease
Publication Year: 1995 Source: Allergy PMID: 8546267 DOI: 10.1111/j.1398-9995.1995.tb01214.x
OBJECTIVES: Children with inflammatory bowel disease (IBD) commonly have altered nutrition and growth. Measurement of serum leptin may enhance other modalities to assess the nutritional state of children with IBD. The aim of the present study was to define the nutritional status of children with newly diagnosed IBD by measuring …
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