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Inflammatory bowel disease in children and adolescents: a somatic and psychiatric investigation
Publication Year: 1991 Source: Acta Paediatr Scand PMID: 1867081 DOI: 10.1111/j.1651-2227.1991.tb11923.x
A registry of patients with inflammatory bowel diseases, ulcerative colitis (UC) and Crohn's disease (CD), was created at the University of Puerto Rico in 1995. Subjects with a documented diagnosis of IBD by clinical, radiologic, endoscopic, and/or pathologic criteria were recruited from the IBD clinics, support groups, and community practices, …
Lower gastrointestinal bleeding in inflammatory bowel disease
Publication Year: 1991 Source: Gastroenterol Jpn PMID: 1884972 DOI: 10.1007/BF02779274
Comment on Wine E, Ossa JC, Gray-Owen SD, Sherman PM. Adherent-invasive Escherichia coli strain LF82 disrupts apical junctional complexes in polarized epithelia. BMC Microbiol. 2009;9:180. doi: 10.1186/1471-2180-9-180. Involvement of intestinal microbes in the pathogenesis of chronic inflammatory bowel diseases (IBD, including Crohn disease and ulcerative colitis) is well established. However, …
Selective increases in type II muscle protein synthesis in NSAID induced inflammatory bowel disease (IBD)
Publication Year: 1991 Source: Biochem Soc Trans PMID: 1889568 DOI: 10.1042/bst019185s
Chronic granulomatous disease (CGD), a genetically heterogeneous primary X-linked or autosomal recessive immunodeficiency, can manifest with gastrointestinal symptoms, including colitis or Crohn's disease. The frequency of CGD carriers among those with chronic colitis/inflammatory bowel disease is unknown. We underwent a pilot study examining the value of prospectively screening patients with …
Gut protein synthetic studies in a NSAID model of inflammatory bowel disease (IBD)
Publication Year: 1991 Source: Biochem Soc Trans PMID: 1889569 DOI: 10.1042/bst019186s
The treatment of patients with inflammatory bowel disease has become more complex in recent years through the introduction of various immunosuppressive agents as well as the approval of monoclonal antibodies against TNF-α and patients receiving such treatment must be carefully monitored. National and international guidelines define a diagnostic and therapeutic …
Inflammatory bowel disease. Part I: Nature and pathogenesis
Publication Year: 1991 Source: Dis Mon PMID: 1893828 DOI: 10.1016/0011-5029(91)90024-6
Comment in Am J Gastroenterol. 2012 Jun;107(6):950; author reply 950-1. Although iron supplementation is commonly prescribed, the amount of elemental iron needed to achieve clinical efficacy, and the optimal method of supplementation, are under debate. Use of intravenous (IV) iron replacement is increasingly being advocated. We explore the physiology of …
Two-color immunofluorescence and flow cytometric analysis of lamina propria lymphocyte subsets in ulcerative colitis and Crohn's disease
Publication Year: 1991 Source: Dig Dis Sci PMID: 1914770 DOI: 10.1007/BF01296815
Liver and biliary abnormalities are well-known complications of inflammatory bowel disease (IBD). It has been suggested that using total parenteral nutrition (TPN) may further impair liver function in these patients; this seems not to be so with total enteral nutrition (TEN). However, prospective trials comparing the incidence of liver function …
The expression and regulation of class II antigens in normal and inflammatory bowel disease peripheral blood monocytes and intestinal epithelium
Publication Year: 1991 Source: Autoimmunity PMID: 1932520 DOI: 10.3109/08916939109006750
BACKGROUND: The effect of comorbidities on postoperative outcomes in patients with inflammatory bowel disease (IBD) has not been explored adequately. We evaluated the prevalence of comorbidities and their effect on postoperative outcomes after an IBD-related operation. METHODS: The Nationwide Inpatient Sample database was used to identify 35 588 patients with …
Intestinal lymphokine-activated killer cells in inflammatory bowel disease
Publication Year: 1991 Source: J Gastroenterol Hepatol PMID: 1932665 DOI: 10.1111/j.1440-1746.1991.tb00887.x
BACKGROUND AND AIMS: The prevalence of inflammatory bowel disease (IBD) is about 0.05% in industrialized countries. The pathogenesis of IBD remains to be further understood. The present study aims to elucidate the expression of integrin αvβ6 in the intestinal mucosa of patients with IBD. MATERIALS AND METHODS: Colonic biopsy was …
Relevance of major stress events as an indicator of disease activity prevalence in inflammatory bowel disease
Publication Year: 1991 Source: Behav Med PMID: 1932843 DOI: 10.1080/08964289.1991.9937553
The effect of macrophages on spontaneous immunoglobulin production by isolated human intestinal mononuclear cells (MNC) is unknown. Depletion of macrophages by adherence to fibronectin or by panning with macrophage-specific monoclonal antibody 3C10 lead to a significant reduction in IgA. IgG and IgM production by intestinal MNC from both normal (n …
6-Mercaptopurine and spermatogenesis in the young rat
Publication Year: 1991 Source: Dig Dis Sci PMID: 1935495 DOI: 10.1007/BF01296399
Cases of interest using affected sib-pair methods to distinguish between recessive and additive (dominant) modes of inheritance of a disease-predisposing gene involve goodness-of-fit tests with a small expected number in the "share-zero parental haplotypes" category, as well as an unknown parameter, the frequency of the disease-predisposing allele. Our simulations demonstrate …
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