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Letter: Microbial manipulation for primary sclerosing cholangitis-associated inflammatory bowel disease-hope on the horizon
Publication Year: 2024 Source: Aliment Pharmacol Ther PMID: 39014921
No Abstract
Infantile and Very Early Onset Inflammatory Bowel Disease: A Multicenter Study
Publication Year: 2024 Source: Pediatrics PMID: 39015095 DOI: 10.1542/peds.2023-064546
OBJECTIVES: This study described disease characteristics and long-term outcomes in patients diagnosed with very early onset inflammatory bowel disease (VEOIBD) (diagnosed before 6 years of age) and infantile-IBD (before 2 years). METHODS: Cases from 21 centers worldwide diagnosed with VEOIBD (2008-2018), with minimum 2 years of follow-up, were retrospectively reviewed. …
Mesenteric Panniculitis
Publication Year: 2024 Source: Inflamm Intest Dis PMID: 39015257
No Abstract
What Happens to Patients with Inflammatory Bowel Disease Who Are Intolerant to Thiopurines?
Publication Year: 2024 Source: Inflamm Intest Dis PMID: 39015258 DOI: 10.1159/000539287
INTRODUCTION: The clinical consequences for patients with inflammatory bowel disease (IBD) who stop treatment owing to side effects have not been fully investigated. METHODS: This retrospective observational study aimed to compare patients who discontinued thiopurine treatment due to side effects with those who tolerated thiopurine treatment in the use of …
Development and Validation of an E-Learning Educational Program for Acquiring Basic Knowledge in Inflammatory Bowel Disease Nursing
Publication Year: 2024 Source: Inflamm Intest Dis PMID: 39015259 DOI: 10.1159/000539005
INTRODUCTION: This study focuses on developing and validating an e-learning educational program for nurturing inflammatory bowel disease (IBD) nursing specialists. METHODS: The program was developed using the attention, relevance, confidence, and satisfaction models within the instructional design framework. The program validation encompassed four steps: (1) nurses took a basic IBD …
FOCUS on NOD2: Advancing IBD Drug Discovery with a User-Informed Machine Learning Framework
Publication Year: 2024 Source: ACS Med Chem Lett PMID: 39015268 DOI: 10.1021/acsmedchemlett.4c00148
In this study, we introduce the Framework for Optimized Customizable User-Informed Synthesis (FOCUS), a generative machine learning model tailored for drug discovery. FOCUS integrates domain expertise and uses Proximal Policy Optimization (PPO) to guide Monte Carlo Tree Search (MCTS) to efficiently explore chemical space. It generates SMILES representations of potential …
Alterations in tryptophan metabolism and de novo NAD(+) biosynthesis within the microbiota-gut-brain axis in chronic intestinal inflammation
Publication Year: 2024 Source: Front Med (Lausanne) PMID: 39015786 DOI: 10.3389/fmed.2024.1379335
BACKGROUND: Inflammatory bowel disease is an incurable and idiopathic disease characterized by recurrent gastrointestinal tract inflammation. Tryptophan metabolism in mammalian cells and some gut microbes comprise intricate chemical networks facilitated by catalytic enzymes that affect the downstream metabolic pathways of de novo nicotinamide adenine dinucleotide (NAD(+)) synthesis. It is hypothesized …
Ultrasound imaging of bowel obstruction in infants and children
Publication Year: 2024 Source: Radiol Med PMID: 39017759
No Abstract
Role of fungus in inflammatory bowel disease: The butterfly effect?
Publication Year: 2024 Source: Indian J Gastroenterol PMID: 39017856
No Abstract
Risankizumab versus Ustekinumab for Moderate-to-Severe Crohn's Disease
Publication Year: 2024 Source: N Engl J Med PMID: 39018531
No Abstract
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