ID：S01

Therapeutic Strategy：Anti-inflammatory

Synonyms：inflammatory

Related Targets：cyclo-oxygenase; proinflammatory cytokine; oxygen-free radicals; lipoxygenase; neutrophil chemotaxis; mast cell activation; nuclear factor-κB activation (NF-κB); PPARγ

Related Drugs：5-Aminosalicylates (5-ASAs); corticosteroids

Mechanism：Crohn's disease and ulcerative colitis are the two main components of inflammatory bowel disease.1 Crohn's disease is a relapsing inflammatory disease, mainly affecting the gastrointestinal tract, and frequently presents with abdominal pain, fever, and clinical signs of bowel obstruction or diarrhoea with passage of blood or mucus, or both.augment peroxisome proliferator-activated receptor-γ (PPARγ) expression and promote PPARγ translocation from the cytoplasm to the nucleus where they result in activation of peroxisome-proliferator hormone response element-driven genes to suppress colitis activity