ID：S04
Therapeutic Strategy：T-cell homing and retention
Synonyms：T-cell trafficking
Related Targets：TH1; type 1 T helper cell; TH2; type 2 T helper cell; TH9, type 9 T helper cell; TH17, type 17 T helper cell; Treg, regulatory T cell; VCAM1, vascular adhesion protein 1.
Related Drugs：vedolizumab; anti-MAdCAM1 antibodies ; etrolizumab
Mechanism：Inhibition of the interaction between α4β7 integrins on T cells with MAdCAM1 on gut endothelial cells (via vedolizumab or etrolizumab) blocks homing of TH1, TH2, TH17 and Treg cells to the inflamed colon in IBD and their subsequent accumulation in the tissue.

Related Literature

Attenuation of colitis in the cotton-top tamarin by anti-alpha 4 integrin monoclonal antibody.
📅 Publication Date: 2025-07-23
📖 Source: The Journal of clinical investigation
# PMID: 7686922
Recent studies have demonstrated the induced expression of endothelial adhesion molecules including E-selectin (also called endothelial leukocyte adhesion molecule-1), vascular ce…
Monoclonal antibodies specific for beta 7 integrin and mucosal addressin cell adhesion molecule-1 (MAdCAM-1) reduce inflammation in the colon of scid mice reconstituted with CD45RBhigh CD4+ T cells.
📅 Publication Date: 2025-07-23
📖 Source: Journal of immunology (Baltimore, Md. : 1950)
# PMID: 9036954
Mucosal addressin cell adhesion molecule-1 (MAdCAM-1) is an adhesion protein expressed on endothelium in mucosal tissues that has been shown to play an important role in the selec…
Progressive multifocal leukoencephalopathy after natalizumab therapy for Crohn's disease.
📅 Publication Date: 2025-07-23
📖 Source: The New England journal of medicine
# PMID: 15947080
The prior diagnosis of fatal astrocytoma in a 60-year-old man with Crohn's disease treated with natalizumab, a monoclonal antibody against alpha4 integrins, was reclassified as JC…
Vedolizumab as induction and maintenance therapy for ulcerative colitis.
📅 Publication Date: 2025-07-23
📖 Source: The New England journal of medicine
# PMID: 23964932
BACKGROUND: Gut-selective blockade of lymphocyte trafficking by vedolizumab may constitute effective treatment for ulcerative colitis. METHODS: We conducted two integrated randomi…