ID：S05
Therapeutic Strategy：Angiogenesis
Synonyms：cell proliferation; vascular permeability
Related Targets：S1PR; NF-κB; STAT3 transcription factors
Related Drugs：ozanimod
Mechanism：The bioactive lipid S1P has been shown to activate NF-κB and STAT3 transcription factors via a family of five G protein-coupled receptors (S1PR) expressed on lymphocytes (so-called inside-out signalling). Functionally, S1PR signalling induces cell proliferation, vascular permeability and angiogenesis

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