ID：S06
Therapeutic Strategy：Anti-fibrosis
Synonyms：fibrosis; tissue remodelling
Related Targets：MMPs; myosin light chain kinase (MLCK); humanized monoclonal antibody GS-5745; CHST15; small-interfering RNA (siRNA)
Related Drugs：GS-5745; STNM01
Mechanism：Tissue remodelling and destruction in patients with IBD is controlled by MMPs. In this context, expression of MMP9 was found to be increased in IBD, particularly in patients with ulcerative colitis. Functional data in experimental models of inflammation have suggested an important role of MMP9 in impairing colonic epithelial permeability and augmenting inflammation via activation of myosin light chain kinase (MLCK)
Related Literature
Matrix metalloproteinase-9: its interplay with angiogenic factors in inflammatory bowel diseases
📅 Publication Date: 2014-05-08
📖 Source: Dis Markers
# PMID: 24803722
🔗 DOI: 10.1155/2014/643645
📖 Source: Dis Markers
# PMID: 24803722
🔗 DOI: 10.1155/2014/643645
Mycobacterium avium ssp. paratuberculosis (MAP) is the cause of Johne's disease,
an inflammatory bowel disorder of ruminants. Due to the similar pathology, MAP
was also suggeste…
Selective Allosteric Inhibition of MMP9 Is Efficacious in Preclinical Models of Ulcerative Colitis and Colorectal Cancer.
📅 Publication Date: 2025-07-23
📖 Source: PloS one
# PMID: 25961845
📖 Source: PloS one
# PMID: 25961845
Expression of matrix metalloproteinase 9 (MMP9) is elevated in a variety of inflammatory and oncology indications, including ulcerative colitis and colorectal cancer. MMP9 is a do…
Pivotal Role of Carbohydrate Sulfotransferase 15 in Fibrosis and Mucosal Healing in Mouse Colitis
📅 Publication Date: 2016-07-14
📖 Source: PLoS One
# PMID: 27410685
🔗 DOI: 10.1371/journal.pone.0158967
📖 Source: PLoS One
# PMID: 27410685
🔗 DOI: 10.1371/journal.pone.0158967
Not found