ID：S09
Therapeutic Strategy：Stem cells Transplantation
Synonyms：mesenchymal stem cells (MSCs)
Related Targets：fistulas; allogeneic stem cells; Cx601 cells
Related Drugs：MSC
Mechanism：Crohn's disease is associated with the development of complex fistulas that are challenging to treat. Adipose-derived allogeneic stem cells have been considered as new treatment approaches for such fistulas

Related Literature

Review article: the efficacy of infliximab in Crohn's disease--healing of fistulae.
📅 Publication Date: 2025-07-23
📖 Source: Alimentary pharmacology & therapeutics
# PMID: 10597336
In the management of fistulae, the current therapeutic approach is the use of a combination of antibiotics and/or a combination of immunomodulatory agents. However, clinicians tre…
Allogeneic Bone Marrow-Derived Mesenchymal Stromal Cells Promote Healing of Refractory Perianal Fistulas in Patients With Crohn's Disease.
📅 Publication Date: 2025-07-23
📖 Source: Gastroenterology
# PMID: 26116801
BACKGROUND & AIMS: Patients with perianal fistulizing Crohn's disease have a poor prognosis because these lesions do not heal well. We evaluated the effects of local administratio…
Ex vivo immunosuppressive effects of mesenchymal stem cells on Crohn's disease mucosal T cells are largely dependent on indoleamine 2,3-dioxygenase activity and cell-cell contact.
📅 Publication Date: 2025-07-23
📖 Source: Stem cell research & therapy
# PMID: 26206376
INTRODUCTION: Crohn's disease (CD) is a disabling chronic enteropathy sustained by a harmful T-cell response toward antigens of the gut microbiota in genetically susceptible subje…
Expanded allogeneic adipose-derived mesenchymal stem cells (Cx601) for complex perianal fistulas in Crohn's disease: a phase 3 randomised, double-blind controlled trial
📅 Publication Date: 2016-08-02
📖 Source: Lancet
# PMID: 27477896
🔗 DOI: 10.1016/S0140-6736(16)31203-X
BACKGROUND: In the meantime, catheter ablation is widely used for the treatment of persistent atrial fibrillation (AF). There is a paucity of data about long-term outcomes. This…