ID：S10
Therapeutic Strategy：Apheresis Therapy
Synonyms：Adsorptive granulocyte/monocyte apheresis (GMA)
Related Targets：granulocytes; monocytes; activated lymphocytes
Related Drugs：/
Mechanism：Apheresis therapy is a novel treatment for IBD developed in Japan, whose main mechanism is to reduce the local inflammatory response by isolating and absorbing one or more specific leukocytes (such as granulocytes, monocytes and activated lymphocytes) in the peripheral blood

Related Literature

Efficacy and safety of granulocyte and monocyte adsorption apheresis for ulcerative colitis: a meta-analysis.
📅 Publication Date: 2025-07-23
📖 Source: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
# PMID: 24268950
BACKGROUND: Safe and effective treatments are required for patients with ulcerative colitis. It was suggested that granulocyte and monocyte adsorption apheresis might play an impo…
Adsorptive Granulocyte and Monocyte Apheresis in the Treatment of Ulcerative Colitis: The First Multicenter Study in China.
📅 Publication Date: 2025-07-23
📖 Source: Gut and liver
# PMID: 27843131
BACKGROUND/AIMS: Patients with active ulcerative colitis (UC) have elevated levels of activated myeloid-derived leukocytes as a source of inflammatory cytokines. The selective dep…
Safety and effectiveness of granulocyte and monocyte adsorptive apheresis in patients with inflammatory bowel disease in special situations: a multicentre cohort study
📅 Publication Date: 2019-11-23
📖 Source: BMC Gastroenterol
# PMID: 31752695
🔗 DOI: 10.1186/s12876-019-1110-1
BACKGROUND: Safety data of the 'real life' use of an infliximab biosimilar, CT-P13 in inflammatory bowel disease (IBD) are still lacking. Our aim was to assess the frequency and…
Efficacy of apheresis as maintenance therapy for patients with ulcerative colitis in an open-label prospective multicenter randomised controlled trial
📅 Publication Date: 2019-12-08
📖 Source: J Gastroenterol
# PMID: 31811562
🔗 DOI: 10.1007/s00535-019-01651-0
Comment in Clin Gastroenterol Hepatol. 2019 Dec;17(13):2648-2650. BACKGROUND & AIMS: Adults with ulcerative colitis (UC) who undergo colectomy at high-volume centers have be…