ID：S12
Therapeutic Strategy：Exosome Therapy
Synonyms：exosomes
Related Targets：TGF-β1; IEC; IL-6IL-1βIFNγ ; IL-17
Related Drugs：/
Mechanism：Exosomes are nanoscale microvesicles released from various types of cells and are widely distributed in biological fluids, which contain important regulatory factors that act on adjacent or distal cells through the systemic system and function in a variety of biological signaling pathways. It has been demonstrated that exosome-mediated immune responses play an important role in the pathogenesis of IBD

Related Literature

Exosomes derived from interleukin-10-treated dendritic cells can inhibit trinitrobenzene sulfonic acid-induced rat colitis
📅 Publication Date: 2010-05-18
📖 Source: Scand J Gastroenterol
# PMID: 20469967
🔗 DOI: 10.3109/00365521.2010.490596
In the present study we describe the preparation and chemical characterization of a caramel with a high (70%) content of difructose dianhydrides (DFAs) and glycosylated derivati…
Isolation of Exosomes from Blood Plasma: Qualitative and Quantitative Comparison of Ultracentrifugation and Size Exclusion Chromatography Methods.
📅 Publication Date: 2025-07-23
📖 Source: PloS one
# PMID: 26690353
BACKGROUND: Exosomes are emerging targets for biomedical research. However, suitable methods for the isolation of blood plasma-derived exosomes without impurities have not yet bee…
Exosome in intestinal mucosal immunity
📅 Publication Date: 2016-04-11
📖 Source: J Gastroenterol Hepatol
# PMID: 27061439
🔗 DOI: 10.1111/jgh.13413
In this study the authors report the first example of spinal pseudarthrosis in a patient with ochronosis, and they describe the application of posterior-only 360° surgery as an …
Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Relieve Inflammatory Bowel Disease in Mice
📅 Publication Date: 2017-06-08
📖 Source: Biomed Res Int
# PMID: 28589143
🔗 DOI: 10.1155/2017/5356760
Faecal calprotectin and faecal occult blood test (FOBT) were widely used in the diagnosis and assessment of intestinal inflammation in inflammatory bowel disease (IBD). Recently…
Exosomes from mesenchymal stromal cells reduce murine colonic inflammation via a macrophage-dependent mechanism
📅 Publication Date: 2019-11-06
📖 Source: JCI Insight
# PMID: 31689240
🔗 DOI: 10.1172/jci.insight.131273
Background: Single incision laparoscopic surgery (SILS) is expanding, enhancing the advantages of multi-port laparoscopic surgery (MLS). Limited literature exists regarding SILS…