| Target ID: | Tar12 |
|---|---|
| ID: | T11451 |
| Target Name: | Toll-like receptor 9 (TLR9) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T11451 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
The TLR9 Agonist Cobitolimod Induces IL10-Producing Wound Healing Macrophages a…
PMID: 31630153
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 6.8
BACKGROUND AND AIMS: The topically applied Toll-like receptor 9 [TLR9] agonist cobitolimod is a first-in-class DNA-based oligonucleotide with demonst…
Cobitolimod for moderate-to-severe, left-sided ulcerative colitis (CONDUCT): a …
PMID: 33031757
Year: 2020
Relationship Type:
Target Validation
Score: 6.3
BACKGROUND: Cobitolimod is a topically administered, DNA-based oligonucleotide that activates Toll-like receptor 9 (TLR9), and previous research has …
Flavokawain B inhibits NF-κB inflammatory signaling pathway activation in infla…
PMID: 38583725
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.8
Inflammatory bowel disease (IBD) is characterized by recurrent inflammatory reactions in the intestinal mucosa, including ulcerative colitis (UC) and…
Emerging Therapies for Ulcerative Colitis: Updates from Recent Clinical Trials
PMID: 37609124
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.8
Ulcerative colitis (UC) is a chronic and progressive inflammatory disorder that affects the colon. The advent of advanced therapies such as biologic …
Lactobacillus acidophilus and HKL Suspension Alleviates Ulcerative Colitis in R…
PMID: 35600873
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.8
Ulcerative colitis (UC) is a chronic non-specific inflammatory bowel disease with complex pathogenesis. The intestinal flora disturbance affects the …
Effectiveness and Safety of Vedolizumab in Anti-TNF-Naïve Patients With Inflamm…
PMID: 29788318
Year: 2018
Relationship Type:
Mechanism Investigation
Score: 5.8
BACKGROUND: Chemokines play key roles in immune homeostasis and inflammatory response. Considering the role of Ccl20 and Toll-like receptor 9 (TLR9)…
Expression and implication of toll-like receptors TLR2, TLR4 and TLR9 in coloni…
PMID: 25318894
Year: 2014
Relationship Type:
Mechanism Investigation
Score: 5.8
Toll-like receptors (TLRs) family may play important roles in inflammatory bowel disease. This study examined the expression of TLR2, TLR4 and TLR9 i…
TLR9 is important for protection against intestinal damage and for intestinal r…
PMID: 22893852
Year: 2012
Relationship Type:
Mechanism Investigation
Score: 5.8
Toll-like receptors (TLRs) are innate receptors critical for host defense, and play a role in normal biological processes. For example, host DNA, a T…
Vitamin D and inflammatory bowel disease: chicken or egg?
PMID: 22649037
Year: 2013
Relationship Type:
Mechanism Investigation
Score: 5.8
BACKGROUND: Chemokines play key roles in immune homeostasis and inflammatory response. Considering the role of Ccl20 and Toll-like receptor 9 (TLR9)…
Direct inhibition of the TXNIP-NLRP3-GSDMD pathway reduces pyroptosis in colono…
PMID: 40195510
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
Ulcerative colitis (UC) is a chronic inflammatory bowel disease. The etiology of UC is multifaceted, and the underlying pathogenesis remains incomple…
Intestinal serotonergic system is modulated by Toll-like receptor 9
PMID: 35670957
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
Intestinal serotonergic system is a key modulator of intestinal homeostasis; however, its regulation is still unclear. Toll-like receptor 9 (TLR9), a…
Negative regulatory NLRs mitigate inflammation via NF-κB pathway signaling in i…
PMID: 37321320
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.1
A subset of Nucleotide-binding and leucine-rich repeat-containing receptors (NLRs) function to mitigate overzealous pro-inflammatory signaling produc…
Qing Hua Chang Yin exerts therapeutic effects against ulcerative colitis throug…
PMID: 23900586
Year: 2013
Relationship Type:
Mechanism Investigation
Score: 5.1
The activation of the Toll-like receptor 4 (TLR4)/nuclear factor-kappaB (NF-kappaB) pathway has been implicated as a key mediator in the pathogenesis…
Advances of exosome regulating‑FXR to repair inflammatory bowel disease (Review)
PMID: 40613233
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.0
Inflammatory bowel disease (IBD), which encompasses ulcerative colitis and Crohn's disease, poses significant treatment difficulties because of its p…
A Systematic Review on Cost-effectiveness Analyses of Therapeutic Drug Monitori…
PMID: 32311018
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.0
Morbidity of inflammatory gastrointestinal (GI) diseases continues to grow resulting in worsen quality of life and increased burden on public medica…
Evaluation of inflammatory bowel disease activity in children using serum trefo…
PMID: 32120375
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 5.0
Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), is a class of severe and chronic diseases of the gastr…
Management of Paediatric Ulcerative Colitis, Part 2: Acute Severe Colitis-An Ev…
PMID: 30044358
Year: 2018
Relationship Type:
Mechanism Investigation
Score: 5.0
We recently have proved that excessive fecal DCA caused by high-fat diet may serve as an endogenous danger-associated molecular pattern to activate …
Signaling pathways induced by serine proteases to increase intestinal epithelia…
PMID: 28671992
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 5.0
Changes in barrier function of the gastrointestinal tract are thought to contribute to the inflammatory bowel diseases Crohn's disease and ulcerative…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio1915 | CHEMBL3975522 | Small molecule | EBOPIPRANT | 599.75 | C30H34FN3O5S2 | NEUTRAL | Details |
| bio1916 | CHEMBL603 | Small molecule | ZAFIRLUKAST | 575.69 | C31H33N3O6S | ACID | Details |
| bio1917 | CHEMBL1200532 | Small molecule | METHDILAZINE HYDROCHLORIDE | 332.9 | C18H21ClN2S | BASE | Details |
| bio1918 | CHEMBL407 | Small molecule | FLUMAZENIL | 303.29 | C15H14FN3O3 | NEUTRAL | Details |
| bio1919 | CHEMBL1742408 | Small molecule | OSEMOZOTAN | 343.38 | C19H21NO5 | BASE | Details |
| bio1920 | CHEMBL29741 | Small molecule | IRAMPANEL | 309.37 | C18H19N3O2 | BASE | Details |
| bio1921 | CHEMBL93747 | Small molecule | NETOGLITAZONE | 381.43 | C21H16FNO3S | NEUTRAL | Details |
| bio1922 | CHEMBL1950554 | Small molecule | BINODENOSON | 391.43 | C17H25N7O4 | NEUTRAL | Details |
| bio1923 | CHEMBL3544908 | Small molecule | AZATADINE MALEATE | 522.55 | C28H30N2O8 | NEUTRAL | Details |
| bio1924 | CHEMBL1230674 | Small molecule | 9-Methylguanine | 165.16 | C6H7N5O | NEUTRAL | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||