| Target ID: | Tar13 |
|---|---|
| ID: | T86552 |
| Target Name: | Tumor necrosis factor receptor type I (TNF-R1) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T86552 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
Evaluation of inflammatory bowel disease activity in children using serum trefo…
PMID: 32120375
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 6.2
Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), is a class of severe and chronic diseases of the gastr…
A Systematic Review on Cost-effectiveness Analyses of Therapeutic Drug Monitori…
PMID: 32311018
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.9
Morbidity of inflammatory gastrointestinal (GI) diseases continues to grow resulting in worsen quality of life and increased burden on public medica…
Flavokawain B inhibits NF-κB inflammatory signaling pathway activation in infla…
PMID: 38583725
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.5
Inflammatory bowel disease (IBD) is characterized by recurrent inflammatory reactions in the intestinal mucosa, including ulcerative colitis (UC) and…
ATF3 restoration as a potential strategy in managing ulcerative colitis: Implic…
PMID: 40318535
Year: 2025
Relationship Type:
Target Validation
Score: 5.5
BACKGROUND: Ulcerative colitis (UC) is a chronic inflammatory bowel disease with limited therapeutic options, particularly for moderate-to-severe cas…
Coordination of ENT2-dependent adenosine transport and signaling dampens mucosa…
PMID: 30333323
Year: 2018
Relationship Type:
Mechanism Investigation
Score: 5.5
Downregulation of P-glycoprotein (P-gp) is implicated in the pathophysiology of inflammatory bowel disease (IBD). Berberine, a principal isoquinolin…
Recent advances in the treatment of IBD: Targets, mechanisms and related therap…
PMID: 37455149
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.4
Inflammatory bowel disease (IBD), as a representative inflammatory disease, currently has multiple effective treatment options available and new ther…
Direct inhibition of the TXNIP-NLRP3-GSDMD pathway reduces pyroptosis in colono…
PMID: 40195510
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
Ulcerative colitis (UC) is a chronic inflammatory bowel disease. The etiology of UC is multifaceted, and the underlying pathogenesis remains incomple…
Signaling pathways induced by serine proteases to increase intestinal epithelia…
PMID: 28671992
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 5.3
Changes in barrier function of the gastrointestinal tract are thought to contribute to the inflammatory bowel diseases Crohn's disease and ulcerative…
The San-Qi-Xue-Shang-Ning formula protects against ulcerative colitis by restor…
PMID: 36603786
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.3
ETHNOPHARMACOLOGICAL RELEVANCE: Ulcerative colitis (UC) is a major cause of morbidity and mortality due to repetitive remissions and relapses, and ma…
Real-world Experience of Anti-tumor Necrosis Factor Therapy for Internal Fistul…
PMID: 29084079
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 5.3
In Crohn's disease, pathogenic Th17-cells express low levels of CD39 ectonucleotidase and are refractory to the immunosuppressive effects of unconj…
Role of tumor necrosis factor-α in the extraintestinal thrombosis associated wi…
PMID: 21987296
Year: 2011
Relationship Type:
Mechanism Investigation
Score: 5.3
Therapeutic intervention in inflammatory bowel diseases (IBDs) is often associated with adverse effects related to drug distribution into non-diseas…
Up-regulation and cytoprotective role of epithelial multidrug resistance-associ…
PMID: 18838379
Year: 2008
Relationship Type:
Mechanism Investigation
Score: 5.3
Tumor necrosis factor (TNF) is key to the pathogenesis of various arthritic diseases and inflammatory bowel disease (IBD). Anti-TNF therapies have p…
Tumor Necrosis Factor-Like Ligand 1A/Death Receptor 3 Signaling Regulates the G…
PMID: 40204100
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.2
BACKGROUND & AIMS: Death receptor 3 (DR3) and its ligand, tumor necrosis factor-like ligand 1A (TL1A), regulate the balance between effector and regu…
Activation of mucosal insulin receptor exacerbates intestinal inflammation by p…
PMID: 38243324
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.2
BACKGROUND: Inflammatory Bowel Diseases (IBD), an autoimmune disease characterised by abnormal intestinal immunity, are related to vital morbidity ar…
The potential mechanism of Bletilla striata in the treatment of ulcerative coli…
PMID: 36576506
Year: 2023
Relationship Type:
Target Validation
Score: 5.2
Ulcerative colitis (UC) is a chronic nonspecific intestinal inflammatory disease, which belongs to a subtype of inflammatory bowel disease, but still…
The pharmacological validation of the Xiao-Jian-Zhong formula against ulcerativ…
PMID: 35987415
Year: 2022
Relationship Type:
Target Validation
Score: 5.2
ETHNOPHARMACOLOGICAL RELEVANCE: Inflammatory bowel disease (IBD) is pathologically characterized by an immune response accommodative insufficiency an…
The deubiquitinase OTUD1 inhibits colonic inflammation by suppressing RIPK1-med…
PMID: 34876703
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.2
BACKGROUND & AIMS: Although interactions between enteric glial cells (EGCs) and enteric mast cells have been demonstrated to play an important role …
Hemophagocytic Lymphohistiocytosis and Inflammatory Bowel Disease: Case Report …
PMID: 32596254
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 5.2
The peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptor proteins that promote ligand-dependent transcription of targ…
PTPN22 regulates NLRP3-mediated IL1B secretion in an autophagy-dependent manner
PMID: 28786745
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 5.2
A variant within the gene locus encoding PTPN22 (protein tyrosine phosphatase, non-receptor type 22) emerged as an important risk factor for auto-inf…
Signal termination of the chemokine receptor CCR9 is governed by an arrestin-in…
PMID: 40154615
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.1
The C-C chemokine receptor type 9 (CCR9) coordinates immune cell migration from the thymus to the small intestine along gradients of the chemokine CC…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio26864 | CHEMBL48361 | Small molecule | DABIGATRAN | 471.52 | C25H25N7O3 | ZWITTERION | Details |
| bio26865 | CHEMBL3975522 | Small molecule | EBOPIPRANT | 599.75 | C30H34FN3O5S2 | NEUTRAL | Details |
| bio26866 | CHEMBL2103920 | Protein | ULARITIDE | 3505.99 | C145H234N52O44S3 | -- | Details |
| bio26867 | CHEMBL2354444 | Small molecule | PIRARUBICIN | 627.64 | C32H37NO12 | BASE | Details |
| bio26868 | CHEMBL1200399 | Small molecule | BUSPIRONE HYDROCHLORIDE | 421.97 | C21H32ClN5O2 | NEUTRAL | Details |
| bio26869 | CHEMBL2107261 | Small molecule | TOLPROPAMINE | 253.39 | C18H23N | BASE | Details |
| bio26870 | CHEMBL603 | Small molecule | ZAFIRLUKAST | 575.69 | C31H33N3O6S | ACID | Details |
| bio26871 | CHEMBL3545408 | Small molecule | NALTALIMIDE | 472.54 | C28H28N2O5 | BASE | Details |
| bio26872 | CHEMBL2110367 | Small molecule | TRIMETHOPRIM SULFATE | 678.73 | C28H38N8O10S | NEUTRAL | Details |
| bio26873 | CHEMBL2105401 | Small molecule | TIOCLOMAROL | 447.34 | C22H16Cl2O4S | ACID | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||