| Target ID: | Tar13 |
|---|---|
| ID: | T86552 |
| Target Name: | Tumor necrosis factor receptor type I (TNF-R1) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T86552 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
Novel targets for mucosal healing in inflammatory bowel disease therapy
PMID: 39571265
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.1
Inflammatory bowel disease (IBD) is a chronic condition affecting the gastrointestinal tract, primarily manifesting as ulcerative colitis (UC) or Cro…
Negative regulatory NLRs mitigate inflammation via NF-κB pathway signaling in i…
PMID: 37321320
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.1
A subset of Nucleotide-binding and leucine-rich repeat-containing receptors (NLRs) function to mitigate overzealous pro-inflammatory signaling produc…
Development, validation and implementation of an in vitro model for the study o…
PMID: 25557335
Year: 2015
Relationship Type:
Target Validation
Score: 5.1
Ulcerative colitis (UC) and Crohn's disease (CD), collectively referred to as inflammatory bowel disease (IBD), are chronic immune disorders affectin…
Current overview of extrinsic and intrinsic factors in etiology and progression…
PMID: 25149979
Year: 2014
Relationship Type:
Mechanism Investigation
Score: 5.1
PURPOSE OF REVIEW: The increased understanding of the molecular mechanisms that are responsible for inflammatory bowel disease (IBD) has led to a wi…
Qing Hua Chang Yin exerts therapeutic effects against ulcerative colitis throug…
PMID: 23900586
Year: 2013
Relationship Type:
Mechanism Investigation
Score: 5.1
The activation of the Toll-like receptor 4 (TLR4)/nuclear factor-kappaB (NF-kappaB) pathway has been implicated as a key mediator in the pathogenesis…
Outcomes of obstetric hospitalizations among women with inflammatory bowel dise…
PMID: 19027089
Year: 2009
Relationship Type:
Mechanism Investigation
Score: 5.1
Human pregnane X receptor (PXR) has been implicated in the pathogenesis of inflammatory bowel disease (IBD). Rifaximin, a human PXR activator, is in…
MicroRNA-22 Regulates the Pro-inflammatory Responses and M1 Polarization of Mac…
PMID: 37469388
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.1
Many microRNAs (miRNAs) are selectively expressed in mammalian immune cells and have been linked to immune responses in host defense and autoimmune d…
The immunosuppressive activity of artemisinin-type drugs towards inflammatory a…
PMID: 34288018
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.1
The sesquiterpene lactone artemisinin from Artemisia annua L. is well established for malaria therapy, but its bioactivity spectrum is much broader. …
Advances of exosome regulating‑FXR to repair inflammatory bowel disease (Review)
PMID: 40613233
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.0
Inflammatory bowel disease (IBD), which encompasses ulcerative colitis and Crohn's disease, poses significant treatment difficulties because of its p…
Management of Paediatric Ulcerative Colitis, Part 2: Acute Severe Colitis-An Ev…
PMID: 30044358
Year: 2018
Relationship Type:
Mechanism Investigation
Score: 5.0
We recently have proved that excessive fecal DCA caused by high-fat diet may serve as an endogenous danger-associated molecular pattern to activate …
Anti-inflammatory and immunomodulatory effects of Glycyrrhiza uralensis fisch. …
PMID: 39929400
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.0
ETHNOPHARMACOLOGICAL RELEVANCE: As a traditional Chinese herb, Glycyrrhiza uralensis Fisch. exhibits a range of pharmacological activities, including…
Advancing therapeutic frontiers: a pipeline of novel drugs for luminal and peri…
PMID: 39711916
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.0
Crohn's disease (CD) is a chronic, complex inflammatory disorder of the gastrointestinal tract that presents significant therapeutic challenges. Desp…
Cinnamaldehyde Ameliorates Dextran Sulfate Sodium-Induced Colitis in Mice by Mo…
PMID: 36653304
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.0
Ulcerative colitis (UC) is a chronic inflammatory gastrointestinal disease mainly associated with immune dysfunction and microbiota disturbance. Cinn…
Increased susceptibility to pneumonia due to tumour necrosis factor inhibition …
PMID: 36159650
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.0
Immunomodulators such as tumour necrosis factor (TNF) inhibitors are used to treat autoimmune conditions by reducing the magnitude of the innate immu…
Patient-Reported Outcome and Clinical Scores Are Equally Accurate in Predicting…
PMID: 34286411
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.0
The interaction disorder between gut microbiota and its host has been documented in different non-communicable diseases (NCDs) such as metabolic syn…
[Neutrophil-lymphocyte ratio at 14th week predicts loss of response to 52-week …
PMID: 32895126
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 5.0
Inflammatory bowel disease (IBD) is characterized by recurring inflammatory disorders in digestive system, and devoid of effective treatment. Propro…
Therapeutic Potential of Lipoxin A(4) in Chronic Inflammation: Focus on Cardiom…
PMID: 32259087
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 5.0
Several studies have shown that failure to resolve inflammation may contribute to the progression of many chronic inflammatory disorders. It has been…
Biphasic Ccl20 regulation by Toll-like receptor 9 through the activation of ERK…
PMID: 27590109
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 5.0
Inflammatory bowel disease (IBD) affects millions of people worldwide. Although the etiology of this disease is uncertain, accumulating evidence ind…
Mentha longifolia protects against acetic-acid induced colitis in rats
PMID: 27282663
Year: 2016
Relationship Type:
Mechanism Investigation
Score: 5.0
AIM: Inflammatory bowel disease (IBD) is an inflammatory disorder, characterized by abnormally increased expression of Toll-like receptors TLR2 and …
[Effect of Tripterygium wilfordii polycoride upon inflammation and TLR4/MyD88 s…
PMID: 27266354
Year: 2016
Relationship Type:
Mechanism Investigation
Score: 5.0
OBJECTIVE: To observe the effect of Tripterygium wilfordii polycoride (TWP) on ulcerative colitis (UC), and its intervention effect on toll-like rece…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio26864 | CHEMBL48361 | Small molecule | DABIGATRAN | 471.52 | C25H25N7O3 | ZWITTERION | Details |
| bio26865 | CHEMBL3975522 | Small molecule | EBOPIPRANT | 599.75 | C30H34FN3O5S2 | NEUTRAL | Details |
| bio26866 | CHEMBL2103920 | Protein | ULARITIDE | 3505.99 | C145H234N52O44S3 | -- | Details |
| bio26867 | CHEMBL2354444 | Small molecule | PIRARUBICIN | 627.64 | C32H37NO12 | BASE | Details |
| bio26868 | CHEMBL1200399 | Small molecule | BUSPIRONE HYDROCHLORIDE | 421.97 | C21H32ClN5O2 | NEUTRAL | Details |
| bio26869 | CHEMBL2107261 | Small molecule | TOLPROPAMINE | 253.39 | C18H23N | BASE | Details |
| bio26870 | CHEMBL603 | Small molecule | ZAFIRLUKAST | 575.69 | C31H33N3O6S | ACID | Details |
| bio26871 | CHEMBL3545408 | Small molecule | NALTALIMIDE | 472.54 | C28H28N2O5 | BASE | Details |
| bio26872 | CHEMBL2110367 | Small molecule | TRIMETHOPRIM SULFATE | 678.73 | C28H38N8O10S | NEUTRAL | Details |
| bio26873 | CHEMBL2105401 | Small molecule | TIOCLOMAROL | 447.34 | C22H16Cl2O4S | ACID | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||