| Target ID: | Tar17 |
|---|---|
| ID: | T48470 |
| Target Name: | Hormone unspecific (HOM) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T48470 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
The San-Qi-Xue-Shang-Ning formula protects against ulcerative colitis by restor…
PMID: 36603786
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 7.8
ETHNOPHARMACOLOGICAL RELEVANCE: Ulcerative colitis (UC) is a major cause of morbidity and mortality due to repetitive remissions and relapses, and ma…
The vagal innervation of the gut and immune homeostasis
PMID: 23023166
Year: 2013
Relationship Type:
Target Validation
Score: 7.3
The central nervous system interacts dynamically with the immune system to modulate inflammation through humoral and neural pathways. Recently, in an…
Homoplantaginin inhibits the progression of ulcerative colitis in mice by regul…
PMID: 40529132
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 6.8
INTRODUCTION: Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by colonic mucosal inflammation and ulceration. This stud…
Disrupting the immune homeostasis: the emerging role of macrophage ferroptosis …
PMID: 40319750
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 6.8
Autoimmune diseases are a class of chronic disorders characterized by the aberrant activation of the immune system, where macrophages play a central …
Mannose coated selenium nanoparticles normalize intestinal homeostasis in mice …
PMID: 39385176
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 6.8
Impaired intestinal homeostasis is a major pathological feature of inflammatory bowel diseases (IBD). Mannose and selenium (Se) both demonstrate pote…
An Orally-Administered Nanotherapeutics with Carbon Monoxide Supplying for Infl…
PMID: 37843108
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 6.8
Traditional drug-based treatments for inflammatory bowel disease (IBD) have significant limitations due to their potential off-target systemic side-e…
The regulation of tissue-specific farnesoid X receptor on genes and diseases in…
PMID: 37812893
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 6.8
Bile acids (BAs) facilitate the absorption of dietary lipids and vitamins and have also been identified as signaling molecules involved in regulating…
NOD-like receptors mediate homeostatic intestinal epithelial barrier function: …
PMID: 37701792
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 6.8
Inflammatory bowel disease (IBD) is a chronic gastrointestinal inflammatory disease that involves host genetics, the microbiome, and inflammatory res…
The transcription factor Cdx2 regulates inflammasome activity through expressio…
PMID: 35985421
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 6.8
The intestine-specific transcription factor Cdx2 is essential for intestinal homeostasis and has been implicated in the pathogenesis of disorders inc…
Lonicera rupicola Hook.f.et Thoms flavonoids ameliorated dysregulated inflammat…
PMID: 35777121
Year: 2022
Relationship Type:
Target Validation
Score: 6.8
BACKGROUND: Lonicera rupicola Hook.f.et Thoms (LRH) is used as a customary medicinal herb in Tibetans. And LRH flavonoids have excellent anti-inflamm…
Homeostatic Function and Inflammatory Activation of Ileal CD8(+) Tissue-Residen…
PMID: 34224909
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 6.8
BACKGROUND & AIMS: Tissue-resident memory T (Trm) cells, both of the CD4 and CD8 lineage, have been implicated in disease flares in inflammatory bowe…
Alpinetin improves intestinal barrier homeostasis via regulating AhR/suv39h1/TS…
PMID: 31676321
Year: 2019
Relationship Type:
Mechanism Investigation
Score: 6.8
The injury of intestinal epithelial barrier is considered as the key pathophysiological process in response to gastrointestinal infection and inflamm…
Intestinal P-glycoprotein exports endocannabinoids to prevent inflammation and …
PMID: 30102254
Year: 2018
Relationship Type:
Mechanism Investigation
Score: 6.8
Neutrophil influx into the intestinal lumen is a critical response to infectious agents, but is also associated with severe intestinal damage observe…
Propionate alleviated colitis by modulating iron homeostasis to inhibit ferropt…
PMID: 40609203
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 6.3
Ulcerative colitis (UC) is a relapsing inflammatory bowel disease with limited effective treatment options. Ferroptosis, characterized by lipid perox…
Faecalibacterium Prausnitzii extracellular vesicles regulating macrophage diffe…
PMID: 40393169
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 6.3
Inflammatory Bowel Disease (IBD) is characterized by chronic inflammation influenced by the depletion of beneficial gut microbiota, a critical factor…
Clca1 deficiency exacerbates colitis susceptibility via impairment of mucus bar…
PMID: 40300372
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 6.3
The intestinal mucus barrier has emerged as a promising therapeutic target for inflammatory bowel disease. Understanding its regulatory mechanisms is…
CO-Releasing Polyoxometalates Nanozyme with Gut Mucosal Immunity and Microbiota…
PMID: 40079617
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 6.3
Disruption of the intestinal epithelial barrier, driven by imbalances in gut mucosal immunity and microbial homeostasis, is central to the onset and …
MAIT cell homing in intestinal homeostasis and inflammation
PMID: 39919191
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 6.3
Mucosa-associated invariant T (MAIT) cells are a large population of unconventional T cells widely distributed in the human gastrointestinal tract. T…
Multifaceted role of CD14 in innate immunity and tissue homeostasis
PMID: 37661484
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 6.3
CD14 is a co-receptor of Toll-like receptor (TLR)- 4, with a critical role in innate immune responses. CD14 recognizes bacterial lipopolysaccharides,…
Role of Muscarinic Acetylcholine Receptors in Intestinal Epithelial Homeostasis…
PMID: 37047478
Year: 2023
Relationship Type:
Therapeutic Applications
Score: 6.3
Inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis, is an intestinal disorder that causes prolonged inflammation…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio44521 | CHEMBL4297525 | Small molecule | RELAMORELIN | 790.99 | C43H50N8O5S | BASE | Details |
| bio44522 | CHEMBL1201620 | Protein | SOMATREM | -- | -- | -- | Details |
| bio44523 | CHEMBL4650335 | Protein | NENDRATAREOTIDE UZATANSINE | 1786.58 | C83H109ClN14O20S4 | -- | Details |
| bio44524 | CHEMBL58547 | Protein | IPAMORELIN | 711.87 | C38H49N9O5 | BASE | Details |
| bio44525 | CHEMBL2357192 | Protein | DESLORELIN ACETATE | 1342.53 | C66H87N17O14 | -- | Details |
| bio44526 | CHEMBL1200516 | Protein | GONADORELIN HYDROCHLORIDE | 1218.77 | C55H76ClN17O13 | -- | Details |
| bio44527 | CHEMBL4540843 | Protein | PANCREATIC POLYPEPTIDE | 4181.78 | C185H287N53O54S2 | -- | Details |
| bio44528 | CHEMBL113313 | Small molecule | CAPROMORELIN | 505.62 | C28H35N5O4 | NEUTRAL | Details |
| bio44529 | CHEMBL1680 | Protein | OCTREOTIDE | 1019.26 | C49H66N10O10S2 | -- | Details |
| bio44530 | CHEMBL1201515 | Protein | PEGVISOMANT | -- | -- | -- | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||