| Target ID: | Tar18 |
|---|---|
| ID: | T00852 |
| Target Name: | Serine/threonine-protein kinase cot (COT) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T00852 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
Sex- and corticotropin-releasing factor receptor 2- dependent actions of urocor…
PMID: 27053649
Year: 2016
Relationship Type:
Mechanism Investigation
Score: 7.3
In inflammatory bowel disease (IBD), compromised restitution of the epithelial barrier contributes to disease severity. Owing to the complexity in t…
Protective effect of α7 nicotinic acetylcholine receptor activation on experime…
PMID: 36058917
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 6.8
BACKGROUND: Inflammatory bowel disease (IBD) is a common chronic remitting disease with no satisfactory treatment. The aim of this study was to inves…
Encenicline, an α7 Nicotinic Acetylcholine Receptor Partial Agonist, Reduces Im…
PMID: 26462538
Year: 2016
Relationship Type:
Mechanism Investigation
Score: 6.8
The alpha7 pentamer nicotinic acetylcholine receptors (nAChRs) are a target in transduction of anti-inflammatory signals from the central nervous sys…
Nicotine protects against DSS colitis through regulating microRNA-124 and STAT3
PMID: 27709266
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 6.3
Although it is generally believed that nicotine accounts for the beneficial effect of smoking on ulcerative colitis, the underlying mechanisms remain…
Corticotropin-Releasing Hormone Receptor 2 Signaling Promotes Mucosal Repair Re…
PMID: 26597886
Year: 2016
Relationship Type:
Mechanism Investigation
Score: 6.3
The corticotropin-releasing hormone family mediates functional responses in many organs, including the intestine. Activation of corticotropin-releasi…
Involvement of stimulation of α7 nicotinic acetylcholine receptors in the suppr…
PMID: 25837923
Year: 2015
Relationship Type:
Mechanism Investigation
Score: 6.3
Ulcerative colitis (UC) involves chronic inflammation of the large intestine. Several agents are used to treat UC, but adverse side effects are remai…
The Yin and Yang of non-neuronal α7-nicotinic receptors in inflammation and aut…
PMID: 22300039
Year: 2012
Relationship Type:
Mechanism Investigation
Score: 6.3
The alkaloid nicotine, a major addictive component of tobacco, exerts anti-inflammatory and immunemodulating activities on multiple cell types, such …
Anti-inflammatory effects of nicotine in obesity and ulcerative colitis
PMID: 21810260
Year: 2011
Relationship Type:
Mechanism Investigation
Score: 6.3
Cigarette smoke is a major risk factor for a number of diseases including lung cancer and respiratory infections. Paradoxically, it also contains nic…
Corticotropin-releasing factor signaling and visceral response to stress
PMID: 20881321
Year: 2010
Relationship Type:
Mechanism Investigation
Score: 6.3
Stress may cause behavioral and/or psychiatric manifestations such as anxiety and depression and also impact on the function of different visceral or…
The Effects of Tocotrienol on Gut Microbiota: A Scoping Review
PMID: 37763286
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.8
Gut dysbiosis has been associated with many chronic diseases, such as obesity, inflammatory bowel disease, and cancer. Gut dysbiosis triggers these d…
Nicotine in Inflammatory Diseases: Anti-Inflammatory and Pro-Inflammatory Effec…
PMID: 35251010
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.8
As an anti-inflammatory alkaloid, nicotine plays dual roles in treating diseases. Here we reviewed the anti-inflammatory and pro-inflammatory effects…
Emerging pharmacotherapy for inflammatory bowel diseases
PMID: 35227890
Year: 2022
Relationship Type:
Therapeutic Applications
Score: 5.8
Inflammatory bowel disease (IBD) refers to a gamut of disorders that are characterized by chronic intestinal inflammation, including ulcerative colit…
PNU-120596, a positive allosteric modulator of α7 nicotinic acetylcholine recep…
PMID: 33132165
Year: 2020
Relationship Type:
Correlation Studies
Score: 5.8
PNU-120596 is a classical positive allosteric modulator (PAM) of alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) and widely used to investigat…
Upregulated nicotinic ACh receptor signaling contributes to intestinal stem cel…
PMID: 33182055
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 5.5
BACKGROUND AND AIMS: Tyrosine kinase 2 [TYK2] is required for the signalling of key cytokines in the pathogenesis of inflammatory bowel disease [IBD…
Decreased Fecal Nicotinamide and Increased Bacterial Nicotinamidase Gene Expres…
PMID: 40357746
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND/OBJECTIVE: Ulcerative colitis (UC) is significantly linked with gut microbiota, which is essential for maintaining gut health. Their metab…
Navigating the pharmacotherapeutic management of comorbid inflammatory bowel di…
PMID: 39316754
Year: 2024
Relationship Type:
Therapeutic Applications
Score: 5.3
INTRODUCTION: Primary sclerosing cholangitis (PSC) is the most specific hepatobiliary extraintestinal manifestation in inflammatory bowel disease (IB…
Nicotinic acetylcholine receptor signaling maintains epithelial barrier integri…
PMID: 38063293
Year: 2023
Relationship Type:
Target Validation
Score: 5.3
Disruption of epithelial barriers is a common disease manifestation in chronic degenerative diseases of the airways, lung, and intestine. Extensive h…
Extracellular nicotinamide phosphoribosyltransferase: role in disease pathophys…
PMID: 37915565
Year: 2023
Relationship Type:
Therapeutic Applications
Score: 5.3
Nicotinamide phosphoribosyltransferase (NAMPT) plays a central role in mammalian cell metabolism by contributing to nicotinamide adenine dinucleotide…
Dual Advanced Therapies and Novel Pharmacotherapies for Moderately to Severely …
PMID: 35595415
Year: 2022
Relationship Type:
Therapeutic Applications
Score: 5.3
Over the past 2 decades, there have been incredible advances in the pharmacotherapeutic options for the treatment of patients with moderately to seve…
Beyond depression and anxiety; a systematic review about the role of corticotro…
PMID: 35275963
Year: 2022
Relationship Type:
Therapeutic Applications
Score: 5.3
Evidence for beneficial effects of corticotropin releasing hormone (CRH) antagonists in abdominal and pelvic organs is emerging in preclinical studie…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio3344 | CHEMBL1088752 | Small molecule | LOSMAPIMOD | 383.47 | C22H26FN3O2 | NEUTRAL | Details |
| bio3345 | CHEMBL450656 | Protein | ROTIGAPTIDE | 617.66 | C28H39N7O9 | NEUTRAL | Details |
| bio3346 | CHEMBL4594271 | Small molecule | BEROTRALSTAT | 562.57 | C30H26F4N6O | BASE | Details |
| bio3347 | CHEMBL5095241 | Small molecule | TUNLAMETINIB | 491.26 | C16H12F2IN3O3S | NEUTRAL | Details |
| bio3348 | CHEMBL3188267 | Small molecule | CAPMATINIB | 412.43 | C23H17FN6O | NEUTRAL | Details |
| bio3349 | CHEMBL3987016 | Small molecule | MIVEBRESIB | 459.47 | C22H19F2N3O4S | NEUTRAL | Details |
| bio3350 | CHEMBL5314585 | Small molecule | GAMCEMETINIB | 469.95 | C22H20ClN5O3S | NEUTRAL | Details |
| bio3351 | CHEMBL5315085 | Unknown | LEISHMANIA INFANTUM EXCRETED SECRETED PROTEINS | -- | -- | -- | Details |
| bio3352 | CHEMBL2104975 | Small molecule | MITRATAPIDE | 717.3 | C36H41ClN8O4S | NEUTRAL | Details |
| bio3353 | CHEMBL297884 | Small molecule | CILUPREVIR | 774.94 | C40H50N6O8S | ACID | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||