| Target ID: | Tar19 |
|---|---|
| ID: | T35212 |
| Target Name: | Vascular endothelial cell growth inhibitor (TNFSF15) |
| Target Type: | Protein |
| CID: | 77999 |
| URL: | https://db.idrblab.net/ttd/data/target/details/T35212 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| Drug60 | Rosiglitazone | Chemical drug | DB00412 | -- | -- | Under clinical trials | Details |
Flavokawain B inhibits NF-κB inflammatory signaling pathway activation in infla…
PMID: 38583725
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.8
Inflammatory bowel disease (IBD) is characterized by recurrent inflammatory reactions in the intestinal mucosa, including ulcerative colitis (UC) and…
Direct inhibition of the TXNIP-NLRP3-GSDMD pathway reduces pyroptosis in colono…
PMID: 40195510
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.6
Ulcerative colitis (UC) is a chronic inflammatory bowel disease. The etiology of UC is multifaceted, and the underlying pathogenesis remains incomple…
Transglutaminase 2 modulates inflammatory angiogenesis via vascular endothelial…
PMID: 40619121
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.5
OBJECTIVES: Immune-driven inflammatory angiogenesis is a crucial component in the pathogenesis of inflammatory bowel disease (IBD). Nevertheless, the…
A Systematic Review on Cost-effectiveness Analyses of Therapeutic Drug Monitori…
PMID: 32311018
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.3
Morbidity of inflammatory gastrointestinal (GI) diseases continues to grow resulting in worsen quality of life and increased burden on public medica…
Management of Paediatric Ulcerative Colitis, Part 2: Acute Severe Colitis-An Ev…
PMID: 30044358
Year: 2018
Relationship Type:
Mechanism Investigation
Score: 5.3
We recently have proved that excessive fecal DCA caused by high-fat diet may serve as an endogenous danger-associated molecular pattern to activate …
Signaling pathways induced by serine proteases to increase intestinal epithelia…
PMID: 28671992
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 5.3
Changes in barrier function of the gastrointestinal tract are thought to contribute to the inflammatory bowel diseases Crohn's disease and ulcerative…
Using novel approaches to conjugate peptides of Macrotermes bellicosus and Curc…
PMID: 40424787
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
This study presents an in-silico approach to develop targeted therapies for Irritable Bowel Disease (IBD) by focusing on TNFSF15. Peptides derived fr…
Ulcer-associated cell lineage expresses genes involved in regeneration and is h…
PMID: 30746716
Year: 2019
Relationship Type:
Mechanism Investigation
Score: 5.2
Protease inhibition has become a new possible approach in the inflammatory bowel disease (IBD) therapy. A serine exopeptidase, dipeptidyl peptidase …
Mucosal CXCR4+ IgG plasma cells contribute to the pathogenesis of human ulcerat…
PMID: 23013725
Year: 2013
Relationship Type:
Mechanism Investigation
Score: 5.1
In Crohn's disease and ulcerative colitis, the tissue-damaging destructive immune response is sustained by defects of counterregulatory mechanisms, …
Regulation of oxidant-induced intestinal permeability by metalloprotease-depend…
PMID: 17220428
Year: 2007
Relationship Type:
Mechanism Investigation
Score: 5.1
Glucocorticoids are potent inhibitors of T cell activation and proinflammatory cytokines and are highly effective treatment for active inflammatory …
Advances of exosome regulating‑FXR to repair inflammatory bowel disease (Review)
PMID: 40613233
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.0
Inflammatory bowel disease (IBD), which encompasses ulcerative colitis and Crohn's disease, poses significant treatment difficulties because of its p…
Evaluation of inflammatory bowel disease activity in children using serum trefo…
PMID: 32120375
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 5.0
Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), is a class of severe and chronic diseases of the gastr…
Increasing the Chemical Variety of Small-Molecule-Based TLR4 Modulators: An Ove…
PMID: 32765484
Year: 2020
Relationship Type:
Target Validation
Score: 5.0
Toll-Like Receptor 4 (TLR4) is one of the receptors of innate immunity. It is activated by Pathogen- and Damage-Associated Molecular Patterns (PAMPs …
Paired immunoglobulin-like receptor B (PIR-B) negatively regulates macrophage a…
PMID: 20398663
Year: 2010
Relationship Type:
Mechanism Investigation
Score: 5.0
Endothelial activation and surface expression of cell adhesion molecules (CAMs) is critical for binding and recruitment of circulating leukocytes in…
Protective association of tumor necrosis factor superfamily 15 (TNFSF15) polymo…
PMID: 25501099
Year: 2014
Relationship Type:
Mechanism Investigation
Score: 5.0
Inflammatory macrophages in colonic mucosa are the leading drivers of the pathology associated with inflammatory bowel disease (IBD). Here we examin…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio35891 | CHEMBL48361 | Small molecule | DABIGATRAN | 471.52 | C25H25N7O3 | ZWITTERION | Details |
| bio35892 | CHEMBL1088752 | Small molecule | LOSMAPIMOD | 383.47 | C22H26FN3O2 | NEUTRAL | Details |
| bio35893 | CHEMBL4297525 | Small molecule | RELAMORELIN | 790.99 | C43H50N8O5S | BASE | Details |
| bio35894 | CHEMBL1201620 | Protein | SOMATREM | -- | -- | -- | Details |
| bio35895 | CHEMBL13608 | Small molecule | TOCERANIB | 396.47 | C22H25FN4O2 | NEUTRAL | Details |
| bio35896 | CHEMBL2103797 | Oligonucleotide | BEVASIRANIB SODIUM | 7049.76 | C200H234N78Na20O140P20 | -- | Details |
| bio35897 | CHEMBL5315060 | Small molecule | ENFLICOXIB | 405.35 | C16H12F5N3O2S | NEUTRAL | Details |
| bio35898 | CHEMBL4650335 | Protein | NENDRATAREOTIDE UZATANSINE | 1786.58 | C83H109ClN14O20S4 | -- | Details |
| bio35899 | CHEMBL3989866 | Small molecule | BICTEGRAVIR | 449.39 | C21H18F3N3O5 | NEUTRAL | Details |
| bio35900 | CHEMBL2110367 | Small molecule | TRIMETHOPRIM SULFATE | 678.73 | C28H38N8O10S | NEUTRAL | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||