| Target ID: | Tar20 |
|---|---|
| ID: | T63165 |
| Target Name: | C-C chemokine receptor type 6 (CCR6) |
| Target Type: | Protein |
| CID: | 146444831 |
| URL: | https://db.idrblab.net/ttd/data/target/details/T63165 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| Drug185 | PF-07054894 | Chemical drug | NULL | -- | -- | Under clinical trials | Details |
Flavokawain B inhibits NF-κB inflammatory signaling pathway activation in infla…
PMID: 38583725
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.5
Inflammatory bowel disease (IBD) is characterized by recurrent inflammatory reactions in the intestinal mucosa, including ulcerative colitis (UC) and…
Direct inhibition of the TXNIP-NLRP3-GSDMD pathway reduces pyroptosis in colono…
PMID: 40195510
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
Ulcerative colitis (UC) is a chronic inflammatory bowel disease. The etiology of UC is multifaceted, and the underlying pathogenesis remains incomple…
Evaluation of inflammatory bowel disease activity in children using serum trefo…
PMID: 32120375
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 5.3
Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), is a class of severe and chronic diseases of the gastr…
GM-CSF-producing CCR2(+) CCR6(+) Th17 cells are pathogenic in dextran sodium su…
PMID: 36641236
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.3
Although excessive immune responses by Th17 cells, a helper T cell subset, are implicated in the pathogenesis of inflammatory bowel disease (IBD), th…
Discovery of small-molecules targeting the CCL20/CCR6 axis as first-in-class in…
PMID: 36067700
Year: 2022
Relationship Type:
Therapeutic Applications
Score: 5.3
The CCL20/CCR6 axis is implicated in the migration of CCR6+ immune cells towards CCL20, its sole ligand, whose expression is increased during inflamm…
SMAD4 Suppresses Colitis-associated Carcinoma Through Inhibition of CCL20/CCR6-…
PMID: 35863523
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND & AIMS: We previously reported that colon epithelial cell silencing of Smad4 increased epithelial expression of inflammatory genes, includ…
ILC2 Lung-Homing in Cystic Fibrosis Patients: Functional Involvement of CCR6 an…
PMID: 32457736
Year: 2020
Relationship Type:
Therapeutic Applications
Score: 5.3
Cystic fibrosis patients suffer from a progressive, often fatal lung disease, which is based on a complex interplay between chronic infections, local…
Integrin α(4)β(7) Blockade Preferentially Impacts CCR6(+) Lymphocyte Subsets in…
PMID: 29196458
Year: 2018
Relationship Type:
Mechanism Investigation
Score: 5.3
Infusion of a simianized anti-alpha(4)beta(7) mAb (Rh-alpha(4)beta(7)) just before and following SIV infection protected rhesus macaques from develop…
Signal termination of the chemokine receptor CCR9 is governed by an arrestin-in…
PMID: 40154615
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.1
The C-C chemokine receptor type 9 (CCR9) coordinates immune cell migration from the thymus to the small intestine along gradients of the chemokine CC…
Negative regulatory NLRs mitigate inflammation via NF-κB pathway signaling in i…
PMID: 37321320
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.1
A subset of Nucleotide-binding and leucine-rich repeat-containing receptors (NLRs) function to mitigate overzealous pro-inflammatory signaling produc…
Advances of exosome regulating‑FXR to repair inflammatory bowel disease (Review)
PMID: 40613233
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.0
Inflammatory bowel disease (IBD), which encompasses ulcerative colitis and Crohn's disease, poses significant treatment difficulties because of its p…
A Systematic Review on Cost-effectiveness Analyses of Therapeutic Drug Monitori…
PMID: 32311018
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.0
Morbidity of inflammatory gastrointestinal (GI) diseases continues to grow resulting in worsen quality of life and increased burden on public medica…
Management of Paediatric Ulcerative Colitis, Part 2: Acute Severe Colitis-An Ev…
PMID: 30044358
Year: 2018
Relationship Type:
Mechanism Investigation
Score: 5.0
We recently have proved that excessive fecal DCA caused by high-fat diet may serve as an endogenous danger-associated molecular pattern to activate …
Signaling pathways induced by serine proteases to increase intestinal epithelia…
PMID: 28671992
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 5.0
Changes in barrier function of the gastrointestinal tract are thought to contribute to the inflammatory bowel diseases Crohn's disease and ulcerative…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio8387 | CHEMBL48361 | Small molecule | DABIGATRAN | 471.52 | C25H25N7O3 | ZWITTERION | Details |
| bio8388 | CHEMBL3975522 | Small molecule | EBOPIPRANT | 599.75 | C30H34FN3O5S2 | NEUTRAL | Details |
| bio8389 | CHEMBL2103920 | Protein | ULARITIDE | 3505.99 | C145H234N52O44S3 | -- | Details |
| bio8390 | CHEMBL2354444 | Small molecule | PIRARUBICIN | 627.64 | C32H37NO12 | BASE | Details |
| bio8391 | CHEMBL1200399 | Small molecule | BUSPIRONE HYDROCHLORIDE | 421.97 | C21H32ClN5O2 | NEUTRAL | Details |
| bio8392 | CHEMBL2107261 | Small molecule | TOLPROPAMINE | 253.39 | C18H23N | BASE | Details |
| bio8393 | CHEMBL2108591 | Antibody | ELSILIMOMAB | -- | -- | -- | Details |
| bio8394 | CHEMBL603 | Small molecule | ZAFIRLUKAST | 575.69 | C31H33N3O6S | ACID | Details |
| bio8395 | CHEMBL3545408 | Small molecule | NALTALIMIDE | 472.54 | C28H28N2O5 | BASE | Details |
| bio8396 | CHEMBL2110367 | Small molecule | TRIMETHOPRIM SULFATE | 678.73 | C28H38N8O10S | NEUTRAL | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||