| Target ID: | Tar21 |
|---|---|
| ID: | T53684 |
| Target Name: | Inflammation pathogenesis (IP) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T53684 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
Direct inhibition of the TXNIP-NLRP3-GSDMD pathway reduces pyroptosis in colono…
PMID: 40195510
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 8.3
Ulcerative colitis (UC) is a chronic inflammatory bowel disease. The etiology of UC is multifaceted, and the underlying pathogenesis remains incomple…
Mechanisms of indigo naturalis on treating ulcerative colitis explored by GEO g…
PMID: 32938944
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 7.8
Oral administration of indigo naturalis (IN) can induce remission in ulcerative colitis (UC); however, the underlying mechanism remains unknown. The …
Therapeutic Potential of Lipoxin A(4) in Chronic Inflammation: Focus on Cardiom…
PMID: 32259087
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 7.8
Several studies have shown that failure to resolve inflammation may contribute to the progression of many chronic inflammatory disorders. It has been…
Ulcer-associated cell lineage expresses genes involved in regeneration and is h…
PMID: 30746716
Year: 2019
Relationship Type:
Mechanism Investigation
Score: 7.8
Protease inhibition has become a new possible approach in the inflammatory bowel disease (IBD) therapy. A serine exopeptidase, dipeptidyl peptidase …
Mineralocorticoid receptor activation contributes to intestinal fibrosis throug…
PMID: 40634309
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 7.3
Intestinal fibrosis is a common complication in inflammatory bowel diseases with no specific therapy. Because mineralocorticoid receptor antagonism p…
Formononetin suppresses colitis-associated colon cancer by targeting lipid synt…
PMID: 40318528
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 7.3
BACKGROUND: Colitis-associated colon cancer (CAC) is a serious gastrointestinal malignancy, with a significantly increased incidence among patients w…
The Relationship Between CSF1R Signaling, Monocyte-Macrophage Differentiation, …
PMID: 40154882
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 7.3
More than 300 genomic loci have been associated with increased susceptibility to inflammatory bowel disease (IBD) through genome-wide association stu…
Indole-3-propionic acid alleviates DSS-induced colitis in mice through macropha…
PMID: 40086057
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 7.3
Ulcerative colitis (UC) is a chronic relapsing inflammatory bowel disease for which current therapeutic approaches still face many dilemmas, and targ…
Advancing therapeutic frontiers: a pipeline of novel drugs for luminal and peri…
PMID: 39711916
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 7.3
Crohn's disease (CD) is a chronic, complex inflammatory disorder of the gastrointestinal tract that presents significant therapeutic challenges. Desp…
Geniposide ameliorates dextran sulfate sodium-induced ulcerative colitis via KE…
PMID: 37187359
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 7.3
ETHNOPHARMACOLOGICAL RELEVANCE: The dried fruit of Gardenia jasminoides Ellis (Zhizi in Chinese) is a traditional medicine used for thousands of year…
RIPK2 as a promising druggable target for autoimmune diseases
PMID: 37023697
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 7.3
Receptor Interacting Serine/Threonine Kinase 2 (RIPK2) is an essential regulator of the inflammatory process and immune response. In innate immunity,…
TGR5 agonist inhibits intestinal epithelial cell apoptosis via cAMP/PKA/c-FLIP/…
PMID: 36997665
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 7.3
Excessive apoptosis of intestinal epithelial cell (IEC) is a crucial cause of disrupted epithelium homeostasis, leading to the pathogenesis of ulcera…
Eudragit-coated chitosan-tripterygium glycoside conjugate microspheres alleviat…
PMID: 36916404
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 7.3
OBJECTIVE: Tripterygium glycoside (TG) is a fat-soluble extract of Tripterygium wilfordii, with anti-inflammatory properties associated with TLR sign…
Early and Late Transcriptional Changes in Blood, Neural, and Colon Tissues in R…
PMID: 35655748
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 7.3
BACKGROUND: Irritable bowel syndrome (IBS) and temporomandibular disorder (TMD) are two chronic pain conditions that frequently overlap in the same i…
29 m(6)A-RNA Methylation (Epitranscriptomic) Regulators Are Regulated in 41 Dis…
PMID: 35211628
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 7.3
We performed a database mining on 102 transcriptomic datasets for the expressions of 29 m(6)A-RNA methylation (epitranscriptomic) regulators (m(6)A-R…
Selective Induction of Cell Death in Human M1 Macrophages by Smac Mimetics Is M…
PMID: 34561230
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 7.3
Inflammatory macrophages have been implicated in many diseases, including rheumatoid arthritis and inflammatory bowel disease. Therefore, targeting m…
Upregulated nicotinic ACh receptor signaling contributes to intestinal stem cel…
PMID: 33182055
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 7.3
BACKGROUND AND AIMS: Tyrosine kinase 2 [TYK2] is required for the signalling of key cytokines in the pathogenesis of inflammatory bowel disease [IBD…
Mechanism of Follicular Helper T Cell Differentiation Regulated by Transcriptio…
PMID: 32766317
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 7.3
Bilobalide, a unique Ginkgo biloba constituent has attracted significant interest as a novel therapeutic option for neuronal protection. However, th…
SMAC mimetics and RIPK inhibitors as therapeutics for chronic inflammatory dise…
PMID: 32071170
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 7.3
New therapeutic approaches for chronic inflammatory diseases such as inflammatory bowel disease, rheumatoid arthritis, and psoriasis are needed becau…
Oroxindin inhibits macrophage NLRP3 inflammasome activation in DSS-induced ulce…
PMID: 31937929
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 7.3
Oroxindin is a flavonoid isolated from the traditional Chinese medicine Huang-Qin, which has shown various pharmacological activities including anti-…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio4154 | CHEMBL456341 | Small molecule | LENABASUM | 400.56 | C25H36O4 | ACID | Details |
| bio4155 | CHEMBL2108152 | Oligonucleotide | AFOVIRSEN SODIUM | -- | -- | -- | Details |
| bio4156 | CHEMBL5095268 | Unknown | BMS-986184 | -- | -- | -- | Details |
| bio4157 | CHEMBL2104745 | Small molecule | PAGOCLONE | 407.9 | C23H22ClN3O2 | NEUTRAL | Details |
| bio4158 | CHEMBL538867 | Small molecule | PATIDEGIB | 504.78 | C29H48N2O3S | BASE | Details |
| bio4159 | CHEMBL3084748 | Small molecule | TROSPIUM CHLORIDE | 427.97 | C25H30ClNO3 | NEUTRAL | Details |
| bio4160 | CHEMBL25 | Small molecule | ASPIRIN | 180.16 | C9H8O4 | ACID | Details |
| bio4161 | CHEMBL4650310 | Small molecule | IP-2018 | 271.32 | C16H17NO3 | BASE | Details |
| bio4162 | CHEMBL1256994 | Small molecule | CITICOLINE SODIUM | 510.31 | C14H25N4NaO11P2 | ACID | Details |
| bio4163 | CHEMBL1231700 | Small molecule | CITICOLINE | 488.33 | C14H26N4O11P2 | ACID | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||