| Target ID: | Tar51 |
|---|---|
| ID: | P01137 |
| Target Name: | Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)] |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://www.uniprot.org/uniprotkb/P01137 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
Clinical Analysis and Network Pharmacology in Revealing the Mechanism of Daifu …
PMID: 40070532
Year: 2025
Relationship Type:
Target Validation
Score: 6.8
BACKGROUND: Daifu Decoction (DFD), a patented herbal prescription used to prevent and treat ulcerative colitis (UC). This study aimed to reveal the e…
The angiotensin receptor blocker, losartan, reduces inflammation and fibrosis, …
PMID: 40390697
Year: 2025
Relationship Type:
Therapeutic Applications
Score: 6.3
BACKGROUND AND AIMS: The renin-angiotensin system (RAS) is known to modulate fibrosis, which is a common complication of ileal Crohn's disease. We te…
Distinct and overlapping functions of glutathione peroxidases 1 and 2 in limiti…
PMID: 31765890
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 6.3
Glutathione peroxidase 2 (GPx2) is one of the five selenoprotein GPxs having a selenocysteine in the active center. GPx2 is strongly expressed in the…
3D-printed Laponite/alginate hydrogel-based suppositories as innovative platfor…
PMID: 40494478
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.8
The secretome of Mesenchymal Stromal Cells (MSCs) has demonstrated effectiveness in the treatment of Inflammatory Bowel Disease (IBD), offering a saf…
Identifying a therapeutic window of opportunity for people living with primary …
PMID: 38743006
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.8
Primary sclerosing cholangitis (PSC) is a variably progressive, fibrosis-causing autoimmune disorder of the intrahepatic and extrahepatic bile ducts …
Sesquiterpene lactones-rich fraction from Aucklandia lappa Decne. alleviates de…
PMID: 35623504
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.8
ETHNOPHARMACOLOGICAL RELEVANCE: Aucklandia lappa Decne. (ALDE) is the general name for Asteraceae plants Yunmuxiang, which has traditionally been pro…
FcγRI plays a critical role in patients with ulcerative colitis relapse
PMID: 33078845
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.8
Ulcerative colitis (UC) is a disease that frequently relapses and affects more than 0.1% general population; the underlying mechanism is poorly under…
Drug discovery approaches targeting 5-lipoxygenase-activating protein (FLAP) fo…
PMID: 28784429
Year: 2018
Relationship Type:
Therapeutic Applications
Score: 5.8
BACKGROUND: Extracorporeal leukocytapheresis (LCAP) is effective for inducing remission of ulcerative colitis (UC). This retrospective observational…
Abundant genetic overlap between blood lipids and immune-mediated diseases indi…
PMID: 25853426
Year: 2015
Relationship Type:
Mechanism Investigation
Score: 5.8
Epidemiological studies suggest a relationship between blood lipids and immune-mediated diseases, but the nature of these associations is not well un…
Association of Vascular Cell Adhesion Molecule-1 Expression in Colonic Mucosa W…
PMID: 40411296
Year: 2025
Relationship Type:
Therapeutic Applications
Score: 5.3
BACKGROUND AND AIM: The association between vascular cell adhesion molecule-1 (VCAM-1) expression and intestinal mucosal inflammation and between VCA…
Combinatorial Effects of Cisplatin and PARP Inhibitor Olaparib on Survival, Int…
PMID: 39940959
Year: 2025
Relationship Type:
Therapeutic Applications
Score: 5.3
This study investigated the effects of the poly (ADP-ribose) polymerase (PARP) inhibitor Olaparib, alone and in combination with cisplatin, on intest…
Recent steroid use and the relapse risk in ulcerative colitis patients with end…
PMID: 38651779
Year: 2024
Relationship Type:
Therapeutic Applications
Score: 5.3
BACKGROUND: Endoscopic healing (EH) is a therapeutic target in ulcerative colitis (UC). However, even patients who have achieved EH relapse frequentl…
Efficacy and Adverse Reactions of Dahuang Mudan decoction Combined with Laparos…
PMID: 37773648
Year: 2023
Relationship Type:
Therapeutic Applications
Score: 5.3
BACKGROUND: Appendicitis is a common acute abdominal disease. Traditional Chinese medicine believes that acute appendicitis is caused by the accumula…
PER2/P65-driven glycogen synthase 1 transcription in macrophages modulates gut …
PMID: 37660913
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.3
Rectal prolapse in serious inflammatory bowel disease is caused by abnormal reactions of the intestinal mucosal immune system. The circadian clock ha…
Genetic overlap between Parkinson's disease and inflammatory bowel disease
PMID: 36687396
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.3
Parkinson's disease and inflammatory bowel disease have been increasingly associated, implying shared pathophysiology. To explore biological explanat…
The San-Qi-Xue-Shang-Ning formula protects against ulcerative colitis by restor…
PMID: 36603786
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.3
ETHNOPHARMACOLOGICAL RELEVANCE: Ulcerative colitis (UC) is a major cause of morbidity and mortality due to repetitive remissions and relapses, and ma…
A novel gut inflammatory rat model by laparotomic injection of peptidoglycan fr…
PMID: 36318321
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
Inflammatory bowel disease includes ulcerative colitis and Crohn's disease, and is globally increasing. An appropriate model system is required to di…
Anemoside B4 protects against chronic relapsing colitis in mice by modulating i…
PMID: 36037770
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND: Anemoside B4 (AB4) is reported to prevent acute colitis when given via intraperitoneal injection by two recent studies. However, whether …
Tolerating clear fluids diet on postoperative day 0 predicts early recovery of …
PMID: 35254522
Year: 2022
Relationship Type:
Target Validation
Score: 5.3
INTRODUCTION: A high proportion of colorectal surgery patients within an enhanced recovery pathway (ERP) do not experience complications but remain h…
Histologic Remission (NANCY Index) is Superior to Endoscopic Mucosal Healing in…
PMID: 35220375
Year: 2023
Relationship Type:
Therapeutic Applications
Score: 5.3
BACKGROUND: Histologic activity is recognized as an important predictor of relapse in ulcerative colitis (UC) patients. Current treatment targets aim…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio102933 | CHEMBL730 | Small molecule | NITROGLYCERIN | 227.08 | C3H5N3O9 | NEUTRAL | Details |
| bio102934 | CHEMBL878 | Small molecule | METOLAZONE | 365.84 | C16H16ClN3O3S | NEUTRAL | Details |
| bio102935 | CHEMBL1079604 | Small molecule | METAXALONE | 221.26 | C12H15NO3 | NEUTRAL | Details |
| bio102936 | CHEMBL1200399 | Small molecule | BUSPIRONE HYDROCHLORIDE | 421.97 | C21H32ClN5O2 | NEUTRAL | Details |
| bio102937 | CHEMBL4297525 | Small molecule | RELAMORELIN | 790.99 | C43H50N8O5S | BASE | Details |
| bio102938 | CHEMBL1200436 | Small molecule | OXANDROLONE | 306.45 | C19H30O3 | NEUTRAL | Details |
| bio102939 | CHEMBL5095183 | Small molecule | IMLUNESTRANT | 524.51 | C29H24F4N2O3 | NEUTRAL | Details |
| bio102940 | CHEMBL1201620 | Protein | SOMATREM | -- | -- | -- | Details |
| bio102941 | CHEMBL1200332 | Small molecule | PROTRIPTYLINE HYDROCHLORIDE | 299.85 | C19H22ClN | BASE | Details |
| bio102942 | CHEMBL3707377 | Small molecule | SEGESTERONE ACETATE | 370.49 | C23H30O4 | NEUTRAL | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||