| Target ID: | Tar51 |
|---|---|
| ID: | P01137 |
| Target Name: | Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)] |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://www.uniprot.org/uniprotkb/P01137 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
Tissue-Resident T Cells in Chronic Relapsing-Remitting Intestinal Disorders
PMID: 34440651
Year: 2021
Relationship Type:
Therapeutic Applications
Score: 5.3
Tissue-resident memory T (T(RM)) cells critically contribute to the rapid immunoprotection and efficient immunosurveillance against pathogens, partic…
Post-operative pain after laparoscopic right hemicolectomy for Crohn's disease:…
PMID: 34217174
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.3
AIM: Surgery for Crohn's disease (CD) is characterized by an enhanced inflammatory response. While inflammation can induce hyperalgesia, post-operati…
Vitamin D and Wnt3A have additive and partially overlapping modulatory effects …
PMID: 31147591
Year: 2019
Relationship Type:
Mechanism Investigation
Score: 5.3
The Wnt/beta-catenin signalling pathway is essential for intestinal epithelium homeostasis, but its aberrant activation is a hallmark of colorectal c…
Ulcer-associated cell lineage expresses genes involved in regeneration and is h…
PMID: 30746716
Year: 2019
Relationship Type:
Mechanism Investigation
Score: 5.3
Protease inhibition has become a new possible approach in the inflammatory bowel disease (IBD) therapy. A serine exopeptidase, dipeptidyl peptidase …
Glatiramer Acetate Enhances Myeloid-Derived Suppressor Cell Function via Recogn…
PMID: 30068593
Year: 2018
Relationship Type:
Mechanism Investigation
Score: 5.3
Glatiramer acetate (GA; Copaxone) is a copolymer therapeutic that is approved by the Food and Drug Administration for the relapsing-remitting form of…
Entyvio lengthen dose-interval study: lengthening vedolizumab dose interval and…
PMID: 29727386
Year: 2018
Relationship Type:
Therapeutic Applications
Score: 5.3
BACKGROUND: Vedolizumab (VDZ), an alpha4beta7 anti-integrin antibody, is efficacious in the induction and maintenance of remission in ulcerative coli…
Overlap syndromes of autoimmune hepatitis: an open question
PMID: 23086110
Year: 2013
Relationship Type:
Therapeutic Applications
Score: 5.3
The headword "overlap syndromes" of liver diseases includes the coexistence of autoimmune hepatitis, primary biliary cirrhosis, and primary sclerosin…
Crohn's disease genotypes of patients in remission vs relapses after infliximab…
PMID: 23049214
Year: 2012
Relationship Type:
Therapeutic Applications
Score: 5.3
AIM: To investigate genetic differences between Crohn's disease (CD) patients with a sustained remission vs relapsers after discontinuing infliximab …
Increased suppressor of cytokine signaling-3 expression predicts mucosal relaps…
PMID: 22535619
Year: 2013
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND: Most biomarkers predicting mucosal relapse of ulcerative colitis (UC) patients in clinical remission represent low levels of mucosal infl…
Systematic review: management options for primary sclerosing cholangitis and it…
PMID: 21501198
Year: 2011
Relationship Type:
Target Validation
Score: 5.3
BACKGROUND: Primary sclerosing cholangitis (PSC) remains a challenging disease to manage. The main goals are prevention of disease progression and re…
Overlap, common features, and essential differences in pediatric granulomatous …
PMID: 20683205
Year: 2010
Relationship Type:
Mechanism Investigation
Score: 5.3
Overlap in the clinical presentation of pediatric granulomatous inflammatory bowel disease may be substantial, depending on the mode of presentation.…
Tilapia head glycolipids reduce inflammation by regulating the gut microbiota i…
PMID: 32219260
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 5.0
Proton-sensing ovarian cancer G-protein coupled receptor (OGR1) plays an important role in pH homeostasis. Acidosis occurs at sites of intestinal i…
Relapse rates and predictors for relapse in a real-life cohort of IBD patients …
PMID: 30907185
Year: 2019
Relationship Type:
Mechanism Investigation
Score: 5.0
Gut microbiota has been well recognized in regulation of intestinal homeostasis and pathogenesis of inflammatory bowel diseases. However, the mechan…
Pharmacokinetic Parameters of Infliximab Influence the Rate of Relapse After De…
PMID: 30860594
Year: 2019
Relationship Type:
Mechanism Investigation
Score: 5.0
Protein tyrosine phosphatases (PTPs) play a critical role in co-ordinating the signaling networks that maintain lymphocyte homeostasis and direct ly…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio102933 | CHEMBL730 | Small molecule | NITROGLYCERIN | 227.08 | C3H5N3O9 | NEUTRAL | Details |
| bio102934 | CHEMBL878 | Small molecule | METOLAZONE | 365.84 | C16H16ClN3O3S | NEUTRAL | Details |
| bio102935 | CHEMBL1079604 | Small molecule | METAXALONE | 221.26 | C12H15NO3 | NEUTRAL | Details |
| bio102936 | CHEMBL1200399 | Small molecule | BUSPIRONE HYDROCHLORIDE | 421.97 | C21H32ClN5O2 | NEUTRAL | Details |
| bio102937 | CHEMBL4297525 | Small molecule | RELAMORELIN | 790.99 | C43H50N8O5S | BASE | Details |
| bio102938 | CHEMBL1200436 | Small molecule | OXANDROLONE | 306.45 | C19H30O3 | NEUTRAL | Details |
| bio102939 | CHEMBL5095183 | Small molecule | IMLUNESTRANT | 524.51 | C29H24F4N2O3 | NEUTRAL | Details |
| bio102940 | CHEMBL1201620 | Protein | SOMATREM | -- | -- | -- | Details |
| bio102941 | CHEMBL1200332 | Small molecule | PROTRIPTYLINE HYDROCHLORIDE | 299.85 | C19H22ClN | BASE | Details |
| bio102942 | CHEMBL3707377 | Small molecule | SEGESTERONE ACETATE | 370.49 | C23H30O4 | NEUTRAL | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||