| Target ID: | Tar59 |
|---|---|
| ID: | P22301 |
| Target Name: | Interleukin-10 (IL-10) (Cytokine synthesis inhibitory factor) (CSIF) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://www.uniprot.org/uniprotkb/P22301 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
Lactobacillus johnsonii alleviates colitis by TLR1/2-STAT3 mediated CD206(+) ma…
PMID: 36398889
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 6.8
Imbalance of gut microbiota homeostasis is related to the occurrence of ulcerative colitis (UC), and probiotics are thought to modulate immune microe…
IL-10 alleviates ulcerative colitis by regulating mitochondrial function throug…
PMID: 40541818
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 6.3
BACKGROUND: Interleukin-10 (IL-10), an anti-inflammatory cytokine, has shown therapeutic effect on autoimmune diseases, yet its effects on UC remain …
Lactobacillus rhamnosus GG induces STING-dependent IL-10 in intestinal monocyte…
PMID: 39895628
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 6.3
Preclinical and clinical observations indicate that the probiotic Lactobacillus rhamnosus GG (LGG) can modulate colonic inflammation. However, the un…
The IL-10 receptor inhibits cell extrinsic signals necessary for STAT1-dependen…
PMID: 36868479
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 6.3
The loss of IL-10R function leads to severe early onset colitis and, in murine models, is associated with the accumulation of immature inflammatory c…
Intraperitoneally Delivered Mesenchymal Stem Cells Alleviate Experimental Colit…
PMID: 35371051
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 6.3
Mesenchymal stem cells (MSCs) show promising therapeutic potential in treating inflammatory bowel disease (IBD), and intraperitoneal delivery of MSCs…
A Notch/STAT3-driven Blimp-1/c-Maf-dependent molecular switch induces IL-10 exp…
PMID: 35169232
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 6.3
Immunosuppressive Interleukin (IL)-10 production by pro-inflammatory CD4(+) T cells is a central self-regulatory function to limit aberrant inflammat…
Fibrosis Related Inflammatory Mediators: Role of the IL-10 Cytokine Family
PMID: 26199463
Year: 2015
Relationship Type:
Mechanism Investigation
Score: 6.3
Importance of chronic fibroproliferative diseases (FDs) including pulmonary fibrosis, chronic kidney diseases, inflammatory bowel disease, and cardio…
Successful Use of Anakinra in a Patient with IL-10R Beta Deficiency: A Case Rep…
PMID: 39950990
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.8
Background: Interleukin-10 (IL-10) is a crucial anti-inflammatory cytokine essential for maintaining immune homeostasis, particularly in the gastroin…
IL-10 constrains sphingolipid metabolism via fatty acid desaturation to limit i…
PMID: 37214856
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.8
Unchecked chronic inflammation is the underlying cause of many diseases, ranging from inflammatory bowel disease to obesity and neurodegeneration. Gi…
MiRNA-374b-5p and miRNA-106a-5p are related to inflammatory bowel disease via r…
PMID: 36437465
Year: 2022
Relationship Type:
Target Validation
Score: 5.8
BACKGROUND: Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is one of the most frequent gastrointestinal disorder…
Discovery and Anti-Inflammatory Activity Evaluation of a Novel CDK8 Inhibitor t…
PMID: 35536548
Year: 2022
Relationship Type:
Therapeutic Applications
Score: 5.8
Increasing the anti-inflammatory cytokine interleukin-10 (IL-10) level is a promising strategy to suppress the progression of pathogenic inflammation…
Long Non-coding RNA MEG3 Alleviated Ulcerative Colitis Through Upregulating miR…
PMID: 33394187
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.8
Ulcerative colitis (UC) is a refractory chronic colitis disease with the particularly complex cause. Recently, long noncoding RNAs (lncRNAs) have bee…
Targeting IL-10, ZO-1 gene expression and IL-6/STAT-3 trans-signaling by a comb…
PMID: 32383169
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.8
Ulcerative colitis (UC) is a chronic inflammatory disease characterized by diffused inflammation of the colon and rectum mucosa. The pathogenesis of …
Microbiota maintain colonic homeostasis by activating TLR2/MyD88/PI3K signaling…
PMID: 31211700
Year: 2019
Relationship Type:
Mechanism Investigation
Score: 5.8
Resident microbiota activate regulatory cells that modulate intestinal inflammation and promote and maintain intestinal homeostasis. IL-10 is a key m…
Actual Anti-TNF Trough Levels Relate to Serum IL-10 in Drug-Responding Patients…
PMID: 30776076
Year: 2019
Relationship Type:
Therapeutic Applications
Score: 5.8
BACKGROUND: Patients with Crohn's disease (CD) responding to anti-tumor necrosis factor (anti-TNF) show great variability in serum drug levels, even …
Sodium butyrate inhibits the NF-kappa B signaling pathway and histone deacetyla…
PMID: 28802151
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 5.8
Butyrate is a bacterial metabolite of dietary fiber in the colon that has been used to treat inflammatory disease. However, the effect of oral supple…
Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrop…
PMID: 28473584
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 5.8
Interleukin 10 (IL-10) is an anti-inflammatory cytokine that plays a critical role in the control of immune responses. However, its mechanisms of act…
IL-10/microRNA-155/SHIP-1 signaling pathway is crucial for commensal bacteria i…
PMID: 27395764
Year: 2016
Relationship Type:
Mechanism Investigation
Score: 5.8
Interleukin 10 (IL-10) microRNA-155 (miR-155)/Src homology 2 domain-containing inositol 5-phosphatase 1 (SHIP-1) signaling pathway plays an important…
Protective mucosal immunity mediated by epithelial CD1d and IL-10
PMID: 24717441
Year: 2014
Relationship Type:
Mechanism Investigation
Score: 5.8
The mechanisms by which mucosal homeostasis is maintained are of central importance to inflammatory bowel disease. Critical to these processes is the…
Early life stress triggers persistent colonic barrier dysfunction and exacerbat…
PMID: 23446335
Year: 2013
Relationship Type:
Mechanism Investigation
Score: 5.8
BACKGROUND: It has become increasingly evident that disease flares in the human inflammatory bowel diseases are influenced by life stress. It is know…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio164514 | CHEMBL730 | Small molecule | NITROGLYCERIN | 227.08 | C3H5N3O9 | NEUTRAL | Details |
| bio164515 | CHEMBL1200332 | Small molecule | PROTRIPTYLINE HYDROCHLORIDE | 299.85 | C19H22ClN | BASE | Details |
| bio164516 | CHEMBL1200348 | Small molecule | SULCONAZOLE NITRATE | 460.77 | C18H16Cl3N3O3S | NEUTRAL | Details |
| bio164517 | CHEMBL495 | Small molecule | ALPROSTADIL | 354.49 | C20H34O5 | ACID | Details |
| bio164518 | CHEMBL4297310 | Small molecule | DORDAVIPRONE | 386.5 | C24H26N4O | NEUTRAL | Details |
| bio164519 | CHEMBL1200574 | Small molecule | SODIUM CHLORIDE | 58.44 | ClNa | -- | Details |
| bio164520 | CHEMBL4650250 | Protein | EFMARODOCOKIN ALFA | -- | -- | -- | Details |
| bio164521 | CHEMBL2108469 | Protein | MUPLESTIM | -- | -- | -- | Details |
| bio164522 | CHEMBL701 | Small molecule | BACLOFEN | 213.66 | C10H12ClNO2 | ZWITTERION | Details |
| bio164523 | CHEMBL2109037 | Protein | ILODECAKIN | -- | -- | -- | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||