| Target ID: | Tar6 |
|---|---|
| ID: | T72835 |
| Target Name: | E-selectin (SELE) |
| Target Type: | Protein |
| CID: | 71600085 |
| URL: | https://db.idrblab.net/ttd/data/target/details/T72835 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| Drug151 | Uproleselan | Chemical drug | DB14829 | -- | -- | Under clinical trials | Details |
Phycocyanin stimulates ulcerative colitis healing via selective activation of c…
PMID: 35777583
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 7.3
Ulcerative colitis (UC) is a chronic inflammatory condition that until this date, lacks curative treatments. Previously, synthetic selective CB2 rece…
Selective Induction of Cell Death in Human M1 Macrophages by Smac Mimetics Is M…
PMID: 34561230
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 7.3
Inflammatory macrophages have been implicated in many diseases, including rheumatoid arthritis and inflammatory bowel disease. Therefore, targeting m…
Protective effect of a novel nonsteroidal organoselenium compound SLL-1-43 on u…
PMID: 40450981
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 6.8
BACKGROUND: Inflammatory bowel disease (IBD), including ulcerative colitis (UC), is a global health concern characterized by chronic inflammation and…
Mannose coated selenium nanoparticles normalize intestinal homeostasis in mice …
PMID: 39385176
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 6.8
Impaired intestinal homeostasis is a major pathological feature of inflammatory bowel diseases (IBD). Mannose and selenium (Se) both demonstrate pote…
pH Dependence of a GPR4 Selective Antagonist Hampers Its Therapeutic Potential
PMID: 37142444
Year: 2023
Relationship Type:
Target Validation
Score: 6.8
Inflammatory bowel disease (IBD) is characterized by chronic mucosal inflammation of the gastrointestinal tract and is associated with extracellular …
Selenocoxib-3, a novel anti-inflammatory therapeutic effectively resolves colit…
PMID: 36001205
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 6.8
Ulcerative colitis (UC) is an idiopathic, chronic and relapsing colonic inflammatory disease. Despite the involvement of diverse intricate mechanisms…
Selection of a picomolar antibody that targets CXCR2-mediated neutrophil activa…
PMID: 33953162
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 6.8
Receptors and their ligands are important therapeutic targets for about one third of marketed drugs. Here, we describe an epitope-guided approach for…
Preclinical characterization of itacitinib (INCB039110), a novel selective inhi…
PMID: 32861662
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 6.8
Pharmacological modulation of the Janus kinase (JAK) family has achieved clinically meaningful therapeutic outcomes for the treatment of inflammatory…
Selective Targeting of TNF Receptors as a Novel Therapeutic Approach
PMID: 32528961
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 6.8
Tumor necrosis factor (TNF) is a central regulator of immunity. Due to its dominant pro-inflammatory effects, drugs that neutralize TNF were develope…
Selective CB2 inverse agonist JTE907 drives T cell differentiation towards a Tr…
PMID: 30552973
Year: 2019
Relationship Type:
Mechanism Investigation
Score: 6.8
Cannabinoids are known to possess anti-inflammatory and immunomodulatory properties, but the mechanisms involved are not fully understood. CB2 is the…
Biochemical characterization and structure determination of a potent, selective…
PMID: 28235803
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 6.8
Matrix metalloproteinase 9 (MMP9) is a member of a large family of proteases that are secreted as inactive zymogens. It is a key regulator of the ext…
Cardiolipins Act as a Selective Barrier to Toll-Like Receptor 4 Activation in t…
PMID: 27208127
Year: 2016
Relationship Type:
Mechanism Investigation
Score: 6.8
Intestinal homeostasis mechanisms must protect the host intestinal tissue from endogenous lipopolysaccharides (LPSs) produced by the intestinal micro…
Selective Allosteric Inhibition of MMP9 Is Efficacious in Preclinical Models of…
PMID: 25961845
Year: Unknown
Relationship Type:
Mechanism Investigation
Score: 6.8
Expression of matrix metalloproteinase 9 (MMP9) is elevated in a variety of inflammatory and oncology indications, including ulcerative colitis and c…
Anti-Inflammatory Mechanisms of Selenium Nanosheets in Ulcerative Colitis: Prot…
PMID: 40583166
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 6.3
Ulcerative colitis (UC) is a complex inflammatory bowel disease characterized by multiple factors. Alleviating inflammation is the primary therapeuti…
Molecular insights into anti-inflammatory activities of selected Indian herbs
PMID: 40154100
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 6.3
Inflammation is a universal response of mammalian tissue to harm, comprising reactions to injuries, pathogens, and foreign particles. Chronic inflamm…
Recent advances in the therapeutic applications of selenium nanoparticles
PMID: 38796570
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 6.3
Selenium nanoparticles (SeNPs) are an appealing carrier for the targeted delivery. The selenium nanoparticles are gaining global attention because of…
Discovery of Selective P2Y(6)R Antagonists with High Affinity and In Vivo Effic…
PMID: 37078976
Year: 2023
Relationship Type:
Therapeutic Applications
Score: 6.3
As a member of purinoceptors, the P2Y(6) receptor (P2Y(6)R) plays a crucial role in modulating immune signals and has been considered as a potential …
Selective JAK1 inhibitors for the treatment of inflammatory bowel disease
PMID: 37004800
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 6.3
Janus kinase (JAK) inhibitors, also known as jakinibs, are third-generation oral small molecules that have expanded the therapeutic options for the m…
Selective autophagy tolerates symbiotic bacteria in the Drosophila intestine
PMID: 33734015
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 6.3
Intestinal epithelium functions as a barrier to protect the host from environmental microbes. Defects in macroautophagy/autophagy combined with intes…
Inactivation of paracellular cation-selective claudin-2 channels attenuates imm…
PMID: 32516134
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 6.3
The tight junction protein claudin-2 is upregulated in disease. Although many studies have linked intestinal barrier loss to local and systemic disea…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio13441 | CHEMBL5315060 | Small molecule | ENFLICOXIB | 405.35 | C16H12F5N3O2S | NEUTRAL | Details |
| bio13442 | CHEMBL2107214 | Small molecule | IOMEPROL | 777.09 | C17H22I3N3O8 | NEUTRAL | Details |
| bio13443 | CHEMBL1257 | Small molecule | ENFLURANE | 184.49 | C3H2ClF5O | NEUTRAL | Details |
| bio13444 | CHEMBL5315109 | Unknown | BOVINE CONCENTRATED LACTOSERUM CONTAINING SPECIFIC IMMUNOGLOBULINS G AGAINST E. COLI F5 (K99) ADHESIN | -- | -- | -- | Details |
| bio13445 | CHEMBL2105897 | Small molecule | BARIUM SULFATE | 233.39 | BaO4S | -- | Details |
| bio13446 | CHEMBL1678 | Small molecule | DONEPEZIL HYDROCHLORIDE | 415.96 | C24H30ClNO3 | BASE | Details |
| bio13447 | CHEMBL2103856 | Small molecule | ATOPAXAR | 527.64 | C29H38FN3O5 | NEUTRAL | Details |
| bio13448 | CHEMBL1160819 | Small molecule | AMMONIA SOLUTION, STRONG | 17.03 | H3N | BASE | Details |
| bio13449 | CHEMBL3185229 | Small molecule | MAGNESIUM CHLORIDE | 203.3 | H12Cl2MgO6 | -- | Details |
| bio13450 | CHEMBL1200930 | Small molecule | RABEPRAZOLE SODIUM | 381.43 | C18H20N3NaO3S | NEUTRAL | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||