| Target ID: | Tar7 |
|---|---|
| ID: | T59626 |
| Target Name: | Leukotriene B4 receptor 1 (LTB4R) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T59626 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
Flavokawain B inhibits NF-κB inflammatory signaling pathway activation in infla…
PMID: 38583725
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.5
Inflammatory bowel disease (IBD) is characterized by recurrent inflammatory reactions in the intestinal mucosa, including ulcerative colitis (UC) and…
Direct inhibition of the TXNIP-NLRP3-GSDMD pathway reduces pyroptosis in colono…
PMID: 40195510
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
Ulcerative colitis (UC) is a chronic inflammatory bowel disease. The etiology of UC is multifaceted, and the underlying pathogenesis remains incomple…
Negative regulatory NLRs mitigate inflammation via NF-κB pathway signaling in i…
PMID: 37321320
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.1
A subset of Nucleotide-binding and leucine-rich repeat-containing receptors (NLRs) function to mitigate overzealous pro-inflammatory signaling produc…
Advances of exosome regulating‑FXR to repair inflammatory bowel disease (Review)
PMID: 40613233
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.0
Inflammatory bowel disease (IBD), which encompasses ulcerative colitis and Crohn's disease, poses significant treatment difficulties because of its p…
A Systematic Review on Cost-effectiveness Analyses of Therapeutic Drug Monitori…
PMID: 32311018
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.0
Morbidity of inflammatory gastrointestinal (GI) diseases continues to grow resulting in worsen quality of life and increased burden on public medica…
Evaluation of inflammatory bowel disease activity in children using serum trefo…
PMID: 32120375
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 5.0
Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), is a class of severe and chronic diseases of the gastr…
Management of Paediatric Ulcerative Colitis, Part 2: Acute Severe Colitis-An Ev…
PMID: 30044358
Year: 2018
Relationship Type:
Mechanism Investigation
Score: 5.0
We recently have proved that excessive fecal DCA caused by high-fat diet may serve as an endogenous danger-associated molecular pattern to activate …
Signaling pathways induced by serine proteases to increase intestinal epithelia…
PMID: 28671992
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 5.0
Changes in barrier function of the gastrointestinal tract are thought to contribute to the inflammatory bowel diseases Crohn's disease and ulcerative…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio45387 | CHEMBL730 | Small molecule | NITROGLYCERIN | 227.08 | C3H5N3O9 | NEUTRAL | Details |
| bio45388 | CHEMBL878 | Small molecule | METOLAZONE | 365.84 | C16H16ClN3O3S | NEUTRAL | Details |
| bio45389 | CHEMBL3975522 | Small molecule | EBOPIPRANT | 599.75 | C30H34FN3O5S2 | NEUTRAL | Details |
| bio45390 | CHEMBL1079604 | Small molecule | METAXALONE | 221.26 | C12H15NO3 | NEUTRAL | Details |
| bio45391 | CHEMBL1200399 | Small molecule | BUSPIRONE HYDROCHLORIDE | 421.97 | C21H32ClN5O2 | NEUTRAL | Details |
| bio45392 | CHEMBL1200436 | Small molecule | OXANDROLONE | 306.45 | C19H30O3 | NEUTRAL | Details |
| bio45393 | CHEMBL5095183 | Small molecule | IMLUNESTRANT | 524.51 | C29H24F4N2O3 | NEUTRAL | Details |
| bio45394 | CHEMBL1200332 | Small molecule | PROTRIPTYLINE HYDROCHLORIDE | 299.85 | C19H22ClN | BASE | Details |
| bio45395 | CHEMBL3707377 | Small molecule | SEGESTERONE ACETATE | 370.49 | C23H30O4 | NEUTRAL | Details |
| bio45396 | CHEMBL5314602 | Small molecule | HYPERICIN SODIUM | 526.43 | C30H15NaO8 | NEUTRAL | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||