| Target ID: | Tar8 |
|---|---|
| ID: | T22655 |
| Target Name: | Mucosal addressin cell adhesion molecule 1 (MADCAM1) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T22655 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
Evaluation of inflammatory bowel disease activity in children using serum trefo…
PMID: 32120375
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 5.6
Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), is a class of severe and chronic diseases of the gastr…
Flavokawain B inhibits NF-κB inflammatory signaling pathway activation in infla…
PMID: 38583725
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.5
Inflammatory bowel disease (IBD) is characterized by recurrent inflammatory reactions in the intestinal mucosa, including ulcerative colitis (UC) and…
Advances of exosome regulating‑FXR to repair inflammatory bowel disease (Review)
PMID: 40613233
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
Inflammatory bowel disease (IBD), which encompasses ulcerative colitis and Crohn's disease, poses significant treatment difficulties because of its p…
Direct inhibition of the TXNIP-NLRP3-GSDMD pathway reduces pyroptosis in colono…
PMID: 40195510
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
Ulcerative colitis (UC) is a chronic inflammatory bowel disease. The etiology of UC is multifaceted, and the underlying pathogenesis remains incomple…
Interleukin-23/Th17 pathways and inflammatory bowel disease
PMID: 19253307
Year: 2009
Relationship Type:
Mechanism Investigation
Score: 5.3
Inflammatory bowel disease (IBD) is characterized by unrestrained T-cell activation that results in the production of a variety of inflammatory cyto…
Protective Effect of Qingchang Wenzhong Decoction on Colitis and Colitis-Relate…
PMID: 37056910
Year: 2023
Relationship Type:
Target Validation
Score: 5.2
PURPOSE: Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by mucosal inflammation, which may develop into ulcerative col…
Prevalence and screening for anaemia in mild to moderate Crohn's disease and ul…
PMID: 28944071
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 5.2
Inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis, is a chronic inflammatory condition of the gastrointestinal…
Targeting leukocyte migration and adhesion in Crohn's disease and ulcerative co…
PMID: 22205271
Year: 2012
Relationship Type:
Mechanism Investigation
Score: 5.2
Crohn's disease and ulcerative colitis are two chronic inflammatory bowel diseases. Current biologic therapies are limited to blocking tumor necrosis…
Sphingosine 1-phosphate modulation and immune cell trafficking in inflammatory …
PMID: 35165437
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.1
Immune cell trafficking is a critical element of the intestinal immune response, both in homeostasis and in pathological conditions associated with i…
The contribution of long non-coding RNAs in Inflammatory Bowel Diseases
PMID: 28869157
Year: 2017
Relationship Type:
Target Validation
Score: 5.1
Inflammatory bowel disease (IBD) is idiopathic, lifelong, immune-mediated diseases, for which curative therapies are not yet available. In the last …
A Systematic Review on Cost-effectiveness Analyses of Therapeutic Drug Monitori…
PMID: 32311018
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.0
Morbidity of inflammatory gastrointestinal (GI) diseases continues to grow resulting in worsen quality of life and increased burden on public medica…
Management of Paediatric Ulcerative Colitis, Part 2: Acute Severe Colitis-An Ev…
PMID: 30044358
Year: 2018
Relationship Type:
Mechanism Investigation
Score: 5.0
We recently have proved that excessive fecal DCA caused by high-fat diet may serve as an endogenous danger-associated molecular pattern to activate …
Signaling pathways induced by serine proteases to increase intestinal epithelia…
PMID: 28671992
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 5.0
Changes in barrier function of the gastrointestinal tract are thought to contribute to the inflammatory bowel diseases Crohn's disease and ulcerative…
Nigakinone alleviates DSS-induced experimental colitis via regulating bile acid…
PMID: 36054406
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.0
The correlation of bile acid (BA) metabolism disorder with the pathogenesis of ulcerative colitis (UC) is realized nowadays. Farnesoid X receptor (FX…
Biphasic Ccl20 regulation by Toll-like receptor 9 through the activation of ERK…
PMID: 27590109
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 5.0
Inflammatory bowel disease (IBD) affects millions of people worldwide. Although the etiology of this disease is uncertain, accumulating evidence ind…
Genome-wide expression profiling implicates a MAST3-regulated gene set in colon…
PMID: 21994190
Year: 2012
Relationship Type:
Mechanism Investigation
Score: 5.0
Mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1) is an important target in the treatment of inflammatory bowel disease (IBD). Recently…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio37793 | CHEMBL730 | Small molecule | NITROGLYCERIN | 227.08 | C3H5N3O9 | NEUTRAL | Details |
| bio37794 | CHEMBL878 | Small molecule | METOLAZONE | 365.84 | C16H16ClN3O3S | NEUTRAL | Details |
| bio37795 | CHEMBL1079604 | Small molecule | METAXALONE | 221.26 | C12H15NO3 | NEUTRAL | Details |
| bio37796 | CHEMBL1200399 | Small molecule | BUSPIRONE HYDROCHLORIDE | 421.97 | C21H32ClN5O2 | NEUTRAL | Details |
| bio37797 | CHEMBL1200436 | Small molecule | OXANDROLONE | 306.45 | C19H30O3 | NEUTRAL | Details |
| bio37798 | CHEMBL5095183 | Small molecule | IMLUNESTRANT | 524.51 | C29H24F4N2O3 | NEUTRAL | Details |
| bio37799 | CHEMBL1200332 | Small molecule | PROTRIPTYLINE HYDROCHLORIDE | 299.85 | C19H22ClN | BASE | Details |
| bio37800 | CHEMBL3707377 | Small molecule | SEGESTERONE ACETATE | 370.49 | C23H30O4 | NEUTRAL | Details |
| bio37801 | CHEMBL5314602 | Small molecule | HYPERICIN SODIUM | 526.43 | C30H15NaO8 | NEUTRAL | Details |
| bio37802 | CHEMBL603 | Small molecule | ZAFIRLUKAST | 575.69 | C31H33N3O6S | ACID | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||