| Target ID: | Tar87 |
|---|---|
| ID: | Q9HBE4 |
| Target Name: | Interleukin-21 (IL-21) (Za11) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://www.uniprot.org/uniprotkb/Q9HBE4 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
IL-21 Controls ILC3 Cytokine Production and Promotes a Protective Phenotype in …
PMID: 31356165
Year: 2019
Relationship Type:
Mechanism Investigation
Score: 5.8
Group 3 innate lymphoid cells (ILC3s) have dual roles in intestinal health, acting in both protective and pathogenic capacities, and importantly, mod…
IL-21 receptor expression in human tendinopathy
PMID: 24757284
Year: 2014
Relationship Type:
Mechanism Investigation
Score: 5.8
The pathogenetic mechanisms underlying tendinopathy remain unclear, with much debate as to whether inflammation or degradation has the prominent role…
The role of IL-19, IL-24, IL-21 and IL-33 in intestinal mucosa of inflammatory …
PMID: 38395629
Year: 2025
Relationship Type:
Therapeutic Applications
Score: 5.3
Interleukins are potential therapeutic targets that can alter the prognosis and progression of inflammatory bowel disease (IBD). The roles of IL-6, I…
Kuijieling decoction regulates the Treg/Th17 cell balance in ulcerative colitis…
PMID: 37451490
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.3
ETHNOPHARMACOLOGICAL RELEVANCE: Ulcerative colitis (UC) is an idiopathic intestinal disease characterized by chronic inflammation with unknown etiolo…
Expression of IL-21 and IL-33 in Intestinal Mucosa of Inflammatory Bowel Diseas…
PMID: 37443579
Year: 2023
Relationship Type:
Therapeutic Applications
Score: 5.3
Interleukins are considered to be potential therapeutic targets that can alter the prognosis and disease progression of IBD. IL-21 has proven to be i…
Elevated levels of IL-2 and IL-21 produced by CD4+ T cells in inflammatory bowe…
PMID: 28685527
Year: 2017
Relationship Type:
Therapeutic Applications
Score: 5.3
CD4+ T cells are considered as a subset of cells that play a pivotal role in the development of inflammatory bowel disease (IBD). The aim of this stu…
Human IL-21 and IL-21R deficiencies: two novel entities of primary immunodefici…
PMID: 25321844
Year: 2014
Relationship Type:
Target Validation
Score: 5.3
PURPOSE OF REVIEW: This review highlights the recent identification of human interleukin-21 (IL-21) and interleukin-21 receptor (IL-21R) deficiencies…
IL-21 as a therapeutic target in inflammatory disorders
PMID: 25162763
Year: 2014
Relationship Type:
Therapeutic Applications
Score: 5.3
INTRODUCTION: IL-21, a cytokine produced by activated CD4(+) cells, activated natural killer T cells and T helper cells in the germinal centers, is i…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio139751 | CHEMBL1200968 | Small molecule | HYDROCORTISONE SODIUM PHOSPHATE | 486.41 | C21H29Na2O8P | ACID | Details |
| bio139752 | CHEMBL2105897 | Small molecule | BARIUM SULFATE | 233.39 | BaO4S | -- | Details |
| bio139753 | CHEMBL1200975 | Small molecule | CLOCORTOLONE PIVALATE | 495.03 | C27H36ClFO5 | NEUTRAL | Details |
| bio139754 | CHEMBL4650250 | Protein | EFMARODOCOKIN ALFA | -- | -- | -- | Details |
| bio139755 | CHEMBL2108469 | Protein | MUPLESTIM | -- | -- | -- | Details |
| bio139756 | CHEMBL2109037 | Protein | ILODECAKIN | -- | -- | -- | Details |
| bio139757 | CHEMBL5095282 | Protein | NEMVALEUKIN ALFA | -- | -- | -- | Details |
| bio139758 | CHEMBL2107112 | Small molecule | TIXOCORTOL PIVALATE | 462.65 | C26H38O5S | NEUTRAL | Details |
| bio139759 | CHEMBL1200762 | Small molecule | BETAMETHASONE SODIUM PHOSPHATE | 516.41 | C22H28FNa2O8P | ACID | Details |
| bio139760 | CHEMBL5095458 | Protein | REZPEGALDESLEUKIN | -- | -- | -- | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||