| Target ID: | Tar9 |
|---|---|
| ID: | T02728 |
| Target Name: | Neurotensin receptor type 1 (NTSR1) |
| Target Type: | Protein |
| CID: | 119192 |
| URL: | https://db.idrblab.net/ttd/data/target/details/T02728 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| Drug63 | Meclinertant | Chemical drug | DB06455 | -- | -- | Under clinical trials | Details |
Flavokawain B inhibits NF-κB inflammatory signaling pathway activation in infla…
PMID: 38583725
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.5
Inflammatory bowel disease (IBD) is characterized by recurrent inflammatory reactions in the intestinal mucosa, including ulcerative colitis (UC) and…
Direct inhibition of the TXNIP-NLRP3-GSDMD pathway reduces pyroptosis in colono…
PMID: 40195510
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
Ulcerative colitis (UC) is a chronic inflammatory bowel disease. The etiology of UC is multifaceted, and the underlying pathogenesis remains incomple…
Evaluation of inflammatory bowel disease activity in children using serum trefo…
PMID: 32120375
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 5.3
Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), is a class of severe and chronic diseases of the gastr…
Negative regulatory NLRs mitigate inflammation via NF-κB pathway signaling in i…
PMID: 37321320
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.1
A subset of Nucleotide-binding and leucine-rich repeat-containing receptors (NLRs) function to mitigate overzealous pro-inflammatory signaling produc…
Advances of exosome regulating‑FXR to repair inflammatory bowel disease (Review)
PMID: 40613233
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.0
Inflammatory bowel disease (IBD), which encompasses ulcerative colitis and Crohn's disease, poses significant treatment difficulties because of its p…
A Systematic Review on Cost-effectiveness Analyses of Therapeutic Drug Monitori…
PMID: 32311018
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.0
Morbidity of inflammatory gastrointestinal (GI) diseases continues to grow resulting in worsen quality of life and increased burden on public medica…
Management of Paediatric Ulcerative Colitis, Part 2: Acute Severe Colitis-An Ev…
PMID: 30044358
Year: 2018
Relationship Type:
Mechanism Investigation
Score: 5.0
We recently have proved that excessive fecal DCA caused by high-fat diet may serve as an endogenous danger-associated molecular pattern to activate …
Signaling pathways induced by serine proteases to increase intestinal epithelia…
PMID: 28671992
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 5.0
Changes in barrier function of the gastrointestinal tract are thought to contribute to the inflammatory bowel diseases Crohn's disease and ulcerative…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio29760 | CHEMBL730 | Small molecule | NITROGLYCERIN | 227.08 | C3H5N3O9 | NEUTRAL | Details |
| bio29761 | CHEMBL48361 | Small molecule | DABIGATRAN | 471.52 | C25H25N7O3 | ZWITTERION | Details |
| bio29762 | CHEMBL878 | Small molecule | METOLAZONE | 365.84 | C16H16ClN3O3S | NEUTRAL | Details |
| bio29763 | CHEMBL3975522 | Small molecule | EBOPIPRANT | 599.75 | C30H34FN3O5S2 | NEUTRAL | Details |
| bio29764 | CHEMBL2103920 | Protein | ULARITIDE | 3505.99 | C145H234N52O44S3 | -- | Details |
| bio29765 | CHEMBL2354444 | Small molecule | PIRARUBICIN | 627.64 | C32H37NO12 | BASE | Details |
| bio29766 | CHEMBL1079604 | Small molecule | METAXALONE | 221.26 | C12H15NO3 | NEUTRAL | Details |
| bio29767 | CHEMBL1200399 | Small molecule | BUSPIRONE HYDROCHLORIDE | 421.97 | C21H32ClN5O2 | NEUTRAL | Details |
| bio29768 | CHEMBL1200436 | Small molecule | OXANDROLONE | 306.45 | C19H30O3 | NEUTRAL | Details |
| bio29769 | CHEMBL5095183 | Small molecule | IMLUNESTRANT | 524.51 | C29H24F4N2O3 | NEUTRAL | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||