| vanH gene in vanA cluster |
ARO:3002942 |
1 |
glycopeptide antibiotic |
antibiotic target alteration |
vanH; glycopeptide resistance gene cluster |
| RbpA |
ARO:3000245 |
1 |
rifamycin antibiotic |
antibiotic target protection |
RbpA bacterial RNA polymerase-binding protein |
| efpA |
ARO:3003955 |
6,521 |
rifamycin antibiotic; isoniazid-like antibiotic |
antibiotic efflux |
major facilitator superfamily (MFS) antibiotic efflux pump |
| tet(C) |
ARO:3000167 |
1 |
tetracycline antibiotic |
antibiotic efflux |
major facilitator superfamily (MFS) antibiotic efflux pump |
| erm(40) |
ARO:3004606 |
1 |
macrolide antibiotic; lincosamide antibiotic; streptogramin antibiotic |
antibiotic target alteration |
Erm 23S ribosomal RNA methyltransferase |
| Erm(39) |
ARO:3000602 |
1 |
macrolide antibiotic; lincosamide antibiotic; streptogramin antibiotic; streptogramin A antibiotic; streptogramin B antibiotic |
antibiotic target alteration |
Erm 23S ribosomal RNA methyltransferase |
| Mycobacterium tuberculosis rpsA mutations conferring resistance to pyrazinamide |
ARO:3004721 |
51 |
pyrazine antibiotic |
antibiotic target alteration |
pyrazinamide resistant rpsA |
| OXA-232 |
ARO:3001778 |
9 |
carbapenem; cephalosporin; penam |
antibiotic inactivation |
OXA beta-lactamase |
| APH(7'')-Ia |
ARO:3002661 |
1 |
aminoglycoside antibiotic |
antibiotic inactivation |
APH(7'') |
| mfpA |
ARO:3003035 |
6,516 |
fluoroquinolone antibiotic |
antibiotic target protection |
quinolone resistance protein (qnr) |
| Mycobacterium tuberculosis katG mutations conferring resistance to isoniazid |
ARO:3003392 |
3,503 |
isoniazid-like antibiotic |
antibiotic target alteration |
isoniazid resistant katG |
| Mycobacterium tuberculosis inhA mutations conferring resistance to isoniazid |
ARO:3003393 |
226 |
isoniazid-like antibiotic |
antibiotic target alteration |
isoniazid resistant inhA |
| Mycobacterium tuberculosis gidB mutation conferring resistance to streptomycin |
ARO:3003470 |
256 |
aminoglycoside antibiotic |
antibiotic target alteration |
antibiotic resistant gidB |
| Mycobacterium tuberculosis pncA mutations conferring resistance to pyrazinamide |
ARO:3003394 |
788 |
pyrazine antibiotic |
antibiotic target alteration |
Pyrazinamide resistant pncA |
| tet(45) |
ARO:3003196 |
2 |
tetracycline antibiotic |
antibiotic efflux |
major facilitator superfamily (MFS) antibiotic efflux pump |
| Mycobacterium tuberculosis rpsL mutations conferring resistance to Streptomycin |
ARO:3003395 |
1,080 |
aminoglycoside antibiotic |
antibiotic target alteration |
antibiotic-resistant rpsL |
| mphL |
ARO:3003072 |
2 |
macrolide antibiotic |
antibiotic inactivation |
macrolide phosphotransferase (MPH) |
| clbA |
ARO:3002814 |
1 |
lincosamide antibiotic; streptogramin antibiotic; streptogramin A antibiotic; oxazolidinone antibiotic; phenicol antibiotic; pleuromutilin antibiotic |
antibiotic target alteration |
Cfr 23S ribosomal RNA methyltransferase |
| vanT gene in vanG cluster |
ARO:3002972 |
8 |
glycopeptide antibiotic |
antibiotic target alteration |
glycopeptide resistance gene cluster; vanT |
| Erm(37) |
ARO:3000392 |
1 |
macrolide antibiotic; lincosamide antibiotic; streptogramin antibiotic; streptogramin A antibiotic; streptogramin B antibiotic |
antibiotic target alteration |
Erm 23S ribosomal RNA methyltransferase |
| Streptomyces rimosus otr(A) |
ARO:3002891 |
2 |
tetracycline antibiotic |
antibiotic target protection |
tetracycline-resistant ribosomal protection protein |
| Mycobacterium tuberculosis kasA mutant conferring resistance to isoniazid |
ARO:3003463 |
1,136 |
isoniazid-like antibiotic |
antibiotic target alteration |
antibiotic resistant kasA |
| Mycobacterium tuberculosis intrinsic murA conferring resistance to fosfomycin |
ARO:3003784 |
6,531 |
phosphonic acid antibiotic |
antibiotic target alteration |
antibiotic-resistant murA transferase |
| Mycobacterium tuberculosis folC with mutation conferring resistance to para-aminosalicylic acid |
ARO:3004157 |
250 |
salicylic acid antibiotic |
antibiotic target alteration |
aminosalicylate resistant dihydrofolate synthase |
| poxtA |
ARO:3004470 |
1 |
tetracycline antibiotic; oxazolidinone antibiotic; phenicol antibiotic |
antibiotic target protection |
Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins |
| Mycobacterium tuberculosis thyA with mutation conferring resistance to para-aminosalicylic acid |
ARO:3004153 |
1,535 |
salicylic acid antibiotic |
antibiotic target alteration |
aminosalicylate resistant thymidylate synthase |
| tetB(P) |
ARO:3000195 |
2 |
tetracycline antibiotic |
antibiotic target protection |
tetracycline-resistant ribosomal protection protein |
| Mycobacterium tuberculosis ndh with mutation conferring resistance to isoniazid |
ARO:3003461 |
259 |
isoniazid-like antibiotic |
antibiotic target alteration |
antibiotic resistant ndh |
| Mycobacterium tuberculosis Rv1258c mutations confer resistance to ethambutol and capreomycin |
ARO:3007185 |
12 |
aminoglycoside antibiotic; polyamine antibiotic; isoniazid-like antibiotic; pyrazine antibiotic |
antibiotic target alteration |
multidrug resistant Rv1258c |
| Mycobacterium tuberculosis Rv1258c mutations confer resistance to pyrazinamide, isoniazid, and streptomycin |
ARO:3007186 |
16 |
aminoglycoside antibiotic; polyamine antibiotic; isoniazid-like antibiotic; pyrazine antibiotic |
antibiotic target alteration |
multidrug resistant Rv1258c |
| blaC |
ARO:3007182 |
6,535 |
cephalosporin; cephamycin; penam; penem |
antibiotic inactivation |
class A Mycobacterium tuberculosis bla beta-lactamase |
| Mycobacterium tuberculosis gyrB mutant conferring resistance to fluoroquinolones |
ARO:3003459 |
91 |
fluoroquinolone antibiotic |
antibiotic target alteration |
fluoroquinolone resistant gyrB |
| TEM-171 |
ARO:3001037 |
1 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| AAC(2')-Ic |
ARO:3002525 |
6,558 |
aminoglycoside antibiotic |
antibiotic inactivation |
AAC(2') |
| APH(3')-Ia |
ARO:3002641 |
3 |
aminoglycoside antibiotic |
antibiotic inactivation |
APH(3') |
| Mycobacterium tuberculosis embR mutant conferring resistance to ethambutol |
ARO:3003455 |
393 |
polyamine antibiotic |
antibiotic target alteration |
ethambutol resistant embR |
| vanY gene in vanM cluster |
ARO:3002961 |
3 |
glycopeptide antibiotic |
antibiotic target alteration |
vanY; glycopeptide resistance gene cluster |
| APH(3')-IIa |
ARO:3002644 |
1 |
aminoglycoside antibiotic |
antibiotic inactivation |
APH(3') |
| Mycobacterium tuberculosis ethA with mutation conferring resistance to ethionamide |
ARO:3003458 |
106 |
thioamide antibiotic |
antibiotic target alteration |
ethionamide resistant ethA |
| Mycobacterium tuberculosis iniC mutant conferring resistance to ethambutol |
ARO:3003451 |
11 |
polyamine antibiotic |
antibiotic target alteration; antibiotic efflux |
Ethambutol resistant iniC |
| qacG |
ARO:3007015 |
3 |
disinfecting agents and antiseptics |
antibiotic efflux |
small multidrug resistance (SMR) antibiotic efflux pump |
| Mycobacterium tuberculosis embA mutant conferring resistance to ethambutol |
ARO:3003453 |
394 |
polyamine antibiotic |
antibiotic target alteration |
ethambutol resistant embA |
| Mycobacterium tuberculosis ribD with mutation conferring resistance to para-aminosalicylic acid |
ARO:3004184 |
2 |
salicylic acid antibiotic |
antibiotic target replacement |
aminosalicylate resistant dihydrofolate reductase |
| qacJ |
ARO:3007014 |
4 |
disinfecting agents and antiseptics |
antibiotic efflux |
small multidrug resistance (SMR) antibiotic efflux pump |
| tet(M) |
ARO:3000186 |
1 |
tetracycline antibiotic |
antibiotic target protection |
tetracycline-resistant ribosomal protection protein |
| Mycobacterium tuberculosis gyrA conferring resistance to fluoroquinolones |
ARO:3003295 |
1,121 |
fluoroquinolone antibiotic |
antibiotic target alteration |
fluoroquinolone resistant gyrA |
| FosBx1 |
ARO:3007372 |
3 |
phosphonic acid antibiotic |
antibiotic inactivation |
fosfomycin thiol transferase |
| TEM-116 |
ARO:3000979 |
2 |
monobactam; cephalosporin; penam; penem |
antibiotic inactivation |
TEM beta-lactamase |
| vanR gene in vanA cluster |
ARO:3002919 |
2 |
glycopeptide antibiotic |
antibiotic target alteration |
glycopeptide resistance gene cluster; vanR |
| vanY gene in vanF cluster |
ARO:3002958 |
2 |
glycopeptide antibiotic |
antibiotic target alteration |
vanY; glycopeptide resistance gene cluster |
| vanY gene in vanG cluster |
ARO:3002959 |
1 |
glycopeptide antibiotic |
antibiotic target alteration |
vanY; glycopeptide resistance gene cluster |
| Mycobacterium tuberculosis iniA mutant conferring resistance to ethambutol |
ARO:3003448 |
147 |
polyamine antibiotic |
antibiotic target alteration; antibiotic efflux |
Ethambutol resistant iniA |
| Mycobacterium tuberculosis embC mutant conferring resistance to ethambutol |
ARO:3003327 |
1,943 |
polyamine antibiotic |
antibiotic target alteration |
ethambutol resistant embC |
| BcI |
ARO:3002877 |
3 |
cephalosporin; penem |
antibiotic inactivation |
class A Bacillus cereus Bc beta-lactamase |
| vanW gene in vanI cluster |
ARO:3003724 |
8 |
glycopeptide antibiotic |
antibiotic target alteration |
vanW; glycopeptide resistance gene cluster |
| vanY gene in vanA cluster |
ARO:3002955 |
5 |
glycopeptide antibiotic |
antibiotic target alteration |
vanY; glycopeptide resistance gene cluster |
| OXA-181 |
ARO:3001784 |
3 |
carbapenem; cephalosporin; penam |
antibiotic inactivation |
OXA beta-lactamase |
| BcII |
ARO:3002878 |
2 |
cephalosporin; penam |
antibiotic inactivation |
subclass B1 Bacillus cereus Bc beta-lactamase |
| vanY gene in vanB cluster |
ARO:3002956 |
11 |
glycopeptide antibiotic |
antibiotic target alteration |
vanY; glycopeptide resistance gene cluster |
| Mycobacterium tuberculosis ethA mutations conferring resistance to prothionamide |
ARO:3005106 |
88 |
thioamide antibiotic |
antibiotic target alteration |
prothionamide resistant ethA |
| HelR |
ARO:3007208 |
1 |
rifamycin antibiotic |
antibiotic target protection |
helicase-like RNA polymerase protection protein |
| Streptomyces venezuelae rox |
ARO:3007209 |
4 |
rifamycin antibiotic |
antibiotic inactivation |
rifampin monooxygenase |
| Mycobacterium tuberculosis tlyA mutations conferring resistance to aminoglycosides |
ARO:3003445 |
3 |
aminoglycoside antibiotic |
antibiotic target alteration |
Antibiotic resistant tlyA |
| Mycobacterium tuberculosis embB mutant conferring resistance to ethambutol |
ARO:3003326 |
2,878 |
polyamine antibiotic |
antibiotic target alteration |
ethambutol resistant embB |
| Enterococcus faecalis chloramphenicol acetyltransferase |
ARO:3004458 |
1 |
phenicol antibiotic |
antibiotic inactivation |
chloramphenicol acetyltransferase (CAT) |
| Mycobacterium tuberculosis katG mutations conferring resistance to prothionamide |
ARO:3005102 |
2,989 |
thioamide antibiotic |
antibiotic target alteration |
prothionamide resistant katG |
| FosB |
ARO:3000172 |
2 |
phosphonic acid antibiotic |
antibiotic inactivation |
fosfomycin thiol transferase |
| Bacillus pumilus cat86 |
ARO:3002672 |
1 |
phenicol antibiotic |
antibiotic inactivation |
chloramphenicol acetyltransferase (CAT) |
| ANT(9)-Ib |
ARO:3007401 |
2 |
aminoglycoside antibiotic |
antibiotic inactivation |
ANT(9) |
| vanA |
ARO:3000010 |
1 |
glycopeptide antibiotic |
antibiotic target alteration |
glycopeptide resistance gene cluster; Van ligase |
| Mycobacterium tuberculosis rpoB mutants conferring resistance to rifampicin |
ARO:3003283 |
6,478 |
rifamycin antibiotic |
antibiotic target alteration; antibiotic target replacement |
rifamycin-resistant beta-subunit of RNA polymerase (rpoB) |
| Planobispora rosea EF-Tu mutants conferring resistance to inhibitor GE2270A |
ARO:3003361 |
2 |
elfamycin antibiotic |
antibiotic target alteration |
elfamycin resistant EF-Tu |
| OXA-833 |
ARO:3006030 |
1 |
carbapenem; cephalosporin; penam |
antibiotic inactivation |
OXA beta-lactamase |
| Bla1 |
ARO:3000090 |
2 |
penam |
antibiotic inactivation |
class A Bacillus anthracis Bla beta-lactamase |
| vanG |
ARO:3002909 |
1 |
glycopeptide antibiotic |
antibiotic target alteration |
glycopeptide resistance gene cluster; Van ligase |
| vanX gene in vanA cluster |
ARO:3002949 |
1 |
glycopeptide antibiotic |
antibiotic target alteration |
vanX; glycopeptide resistance gene cluster |