• BMDC holds the 2nd SAB Meeting

    The 2nd SAB Meeting of Bio-Med Big Data Center (BMDC) was successfully held online on November 17th, 2020, hosted by Prof. Yixue Li, Director of BMDC. Eight SAB members from China, United States, Britain, Germany and Canada participated the meeting. The meeting took the virtual form due to the Covid-19 situation.
    Prof. Zefeng Wang, Managing Director of CAS-MPG Partner Institute for Computational Biology, SINH, CAS first gave an opening address, followed by a status report by Prof. Yixue Li. Prof. Li, outlining the progress BMDC had made and challenges it was facing in the past two years since last SAB meeting. He also introduced BMDCs future plan in research, collaboration and data services.
    Prof. Rolf Apweiler, the co-chair of the SAB, then chaired the discussion session. SAB members congratulated to BMDC for the progress it had achieved. Constructive suggestions were made focusing on BMDCs collaboration with domestic and international partners in the area of data services. Prof. HenningHermjakob from EMBL was introduced as the new member of SAB.
    At the end of the meeting, Prof. Rolf Apweiler and Acad. Guoping Zhao, Chief Scientist of BMDC, gave closing notes.

  • New Home of Data Resources and Services from Bio-Med Big Data Center

    The new version of BMDC website features:
    1.A clear BMDCs scientific and service scope as demonstrated by its Mission Statement and the Trinity of Biomedical Information Infrastructure service model in the front page;
    2. The reorganization of BMDC data resources and services for logical grouping (databases and tool & pipelines) and easy access. Their service validity is carefully accessed and tested;
    3. The introduction of search capacity to allow easy discovery of data resource and service made available to the public at the website. Although only 4 databases are currently searchable in this -release of the search engine, more resources and services will be added for search when they become available.
    Please send any comments and suggestions for the further improvement of the website to bmdc-support@picb.ac.cn.

  • Bio-Med Big Data Center (BMDC) assisted the research that established Long-Term Expansion of Pancreatic Islet Organoids from Resident Procr+ Progenitors

    A novel endocrine progenitor in adult mouse pancreas and an in-vitro method for the induction and long-term expansion of islet-like organoids were establishes for the first time by the research group led by Prof. Yi Arial Zeng, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, CAS. The study was published by CELL on the 19th of March, 2020 (Long-Term Expansion of Pancreatic Islet Organoids from Resident Procr+ Progenitors, https://doi.org/10.1016/j.cell.2020.02.048 ). Omics Core of BMDC assisted the research with the construction of single-cell RNA library, and the analysis of single-cell RNA sequencing data. In the meantime, the relevant data were deposited and published at the NODE database.

  • A joint development of an automatic analysis cloud platform for virus genome identification (VIC)

    On February 10, an automatic analysis cloud platform for virus genome identification (VIC), jointly developed by Institut Pasteur of Shanghai , CAS and Bio-Med Big Data Center, SINH, CAS using Huawei cloud computing technology, was released. Its service can be accessed at https://biosino.org/vic/.
    The platform takes Illumina-based RNAseq data as inputs, has following key functions (refer to the left figure):
    1) Automatic data quality control;
    2) Genome mapping and assembly;
    3) Virus composition and abundance analysis for various viruses, including novel coronavirus COVID-19.

  • New updates in NODE submission portal

    Enhancements added to v3 NODE submission portal include:
    1: Batch upload: "step by step-multiple" creates batch-upload for samples, experiments and archive records;
    2: Multi-omics submission: users can now upload raw data of multiple omics data types into one project;
    3: Append new data to an existing project: users can use "step by step-multiple" to append new samples and experiments to an existing projects.

  • Bio-Med Big Data Center (BMDC) assists the research that reveals crucial function of circular-RNA in innate immune process

    A latest research on circular-RNA and its role in innate immune regulation, by Prof. Li Yangs laboratory of CAS-MPG Partner Institute for Computational Biology, was published in a prestigious scientific journal Cell (Structure and degradation of circular RNAs regulate PKR activation in innate immunity, DOI: 10.1016/j.cell.2019.03.046). Studys nucleic sequence data were produced by Multi-Omics Core Facility of BMDC, and managed by NODE database, a new generation of data hub for multi-omics big data.

  • Bio-Med Big Data Center (BMDC) participates in a study of novel off-target analysis technique

    Prof. Yixue Li, the director of BMDC, co-authored a research article with Prof. Hui Yang of Key Laboratory of Primate Neurobiology, CAS and Lars M. Steinmetz of Stanford University on a novel off-target analysis technique genome-wide off-target analysis by two-cell embryo injection (GOTI), published on Feb. 28th 2019 in Science (Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos, DOI: 10.1126/science.aav9973). By using this technique, they observed the occurrence of a large number of unpredictable off-target single-nucleotide editing events, suggesting the serious safety risk of base-editing technique.