5-hydroxytryptamine receptor 2B

Basic Information

Uniprot ID:	P41595
Secondary ID:	B2R9D5
Symbol:	HTR2B
Other Name:	5-HT-2B,5-HT2B,Serotonin receptor 2B
Class:	Single Protein
Type:	pro-fibrotic
Molecular Function:	G-protein coupled receptor,Receptor,Transducer

Target Classification

Category I	Category II	Category III
Extracellular	G protein-coupled receptor	Serotonin receptor

Related Compound

Target ID	Name	Interaction
D0011	Terguride	antagonist
D0358	C-122	antagonist
D0366	Spiperone	antagonist
D0374	SB204741	inhibitor
D0461	LY-53857	antagonist
D0462	Metitepine	antagonist

Fibrosis Related Property

Reference Record 1

PubMed ID	28821451	Compound ID	D0011
CAS	37686-84-3	Name	Terguride
Model	rat	Fibrosis Disease	Pulmonary fibrosis
Process I	attenue inflammation
Process II
Process III	prevenet collagen deposition
Mechanism	Targeting TGF-β1 signaling

Reference Record 2

PubMed ID	21914448	Compound ID	D0358
CAS	1361151-50-9	Name	C-122
Model	vitro,rat	Fibrosis Disease	Pulmonary fibrosis
Process I	attenue inflammation
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 3

PubMed ID	21518801	Compound ID	D0374
CAS	152239-46-8	Name	SB204741
Model	vitro,human,mice	Fibrosis Disease	Systemic sclerosis
Process I
Process II	myofibroblasts differentiation,myofibroblasts accumulation
Process III	prevenet collagen deposition
Mechanism

Reference Record 4

PubMed ID	16936262	Compound ID	D0366
CAS	749-02-0	Name	Spiperone
Model	vitro	Fibrosis Disease	Liver fibrosis
Process I
Process II	HSCs proliferation,HSCs apoptosis
Process III
Mechanism

Reference Record 5

PubMed ID	16936262	Compound ID	D0461
CAS	60634-51-7	Name	LY-53857
Model	vitro	Fibrosis Disease	Liver fibrosis
Process I
Process II	HSCs proliferation,HSCs apoptosis
Process III
Mechanism

Reference Record 6

PubMed ID	16936262	Compound ID	D0462
CAS	20229-30-5	Name	Metitepine
Model	vitro	Fibrosis Disease	Liver fibrosis
Process I
Process II	HSCs proliferation,HSCs apoptosis
Process III
Mechanism