Model Information
| Model ID: | M033 |
|---|---|
| Category: | In vivo |
| Classification: | Genetically engineered model (conventional knock-out) |
| Type: | TGF-β-/- mice model |
| Source: | Mice |
|---|---|
| References: | 24906689 |
Model Name
TGF-β-/- mice colitis
Description
TGF-β gene knock-out, multi-organ dysfunction including severe colitis, dies within 4–5 weeks, clinical features include colonic inflammation, histological changes involve macrophage hyper-activation