Model Information
| Model ID: | M038 |
|---|---|
| Category: | In vivo |
| Classification: | Genetically engineered model (conventional knock-out) |
| Type: | Gαi2-/- mice model |
| Source: | Mice |
|---|---|
| References: | 24906689 |
Model Name
Gαi2-/- mice colitis
Description
Gαi2 gene knock-out, spontaneous severe colitis by 8–12 weeks of age, resembles UC, clinical features include colonic thickening, histological changes involve lymphocyte/neutrophil infiltration, crypt loss