| Drug ID: | Drug181 |
|---|---|
| Drug Name: | Steroids |
| CID: | 139082353 |
| DrugBank ID: | NULL |
| Modality: | Small Molecule |
| Groups: | NULL |
| US Approved: | NULL |
| Other Approved: | NULL |
| Identifier: | NCT05702879, , NCT03460847 |
| Molecular Formula: | C26H44N2O |
| Molecular Weight: | 400.6 g/mol |
| Isomeric SMILES: | C[C@H]([C@@H]1CC[C@H]2[C@]1(CC[C@@H]3[C@@H]2CC=C4[C@]3(CC[C@@H](C4)N(C)C)C)C)N(C)C(=O)C |
| Synonyms: | Steroid; 3alpha-Dimethylamino-20-(N-methylacetamido)pregn-5-ene; Steroids; Steroid Compound; Arnolds, Gear, Gym Candy, Juice, Pumpers, Roids, Stackers, Weight Gainers |
| Phase 0: | 0 |
| Phase 1: | 0 |
| Phase 2: | 0 |
| Phase 3: | 0 |
| Phase 4: | 0 |
| Description: | NULL |
Molecular Structure
Knowledge Graph
| dtID | CID | Compound Name | Gene ID | Gene Name | Species | PubMed IDs | Action |
|---|---|---|---|---|---|---|---|
| dt1299 | 139082353 | Steroids | 1576 | CYP3A4 | Homo sapiens (human) | 15955870 | Steroids results in increased expression of CYP3A4 |
| dt1300 | 139082353 | Steroids | 2554 | GABRA1 | Rattus norvegicus (Norway rat) | 18275132 | GABRA1 protein mutant form results in decreased susceptibility to steroids analog|steroids analog promotes the reaction [gamma-aminobutyric acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] |
| dt1301 | 139082353 | Steroids | 2561 | GABRB2 | Rattus norvegicus (Norway rat) | 18275132 | Steroids analog promotes the reaction [gamma-aminobutyric acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] |
| dt1302 | 139082353 | Steroids | 2566 | GABRG2 | Rattus norvegicus (Norway rat) | 18275132 | Steroids analog promotes the reaction [gamma-aminobutyric acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] |
| dt1303 | 139082353 | Steroids | 3565 | IL4 | Rattus norvegicus (Norway rat) | 10685002 | Steroids results in decreased expression of IL4 protein |
| dt1304 | 139082353 | Steroids | 5069 | PAPPA | Mus musculus (house mouse) | 20130263 | PAPPA protein affects the chemical synthesis of steroids |
| dt1305 | 139082353 | Steroids | 5443 | POMC | Rattus norvegicus (Norway rat) | 20021565 | POMC protein affects the reaction [ethanol results in increased abundance of steroids] |
| dt1306 | 139082353 | Steroids | 5443 | POMC | Rattus norvegicus (Norway rat) | 1668613 | POMC protein alternative form affects the abundance of steroids |
| dt1307 | 139082353 | Steroids | 103142 | Rdh9 | Mus musculus (house mouse) | 17270348 | RDH9 protein results in increased metabolism of steroids |
| dt1308 | 139082353 | Steroids | 6770 | STAR | Rattus norvegicus (Norway rat) | 12699903 | [manganese chloride results in decreased expression of STAR protein] which results in decreased chemical synthesis of steroids |
Phase Distribution
Phase Description
- Phase 0: Exploratory trials to assess drug behavior in humans
- Phase 1: Safety trials to determine safe dosage range
- Phase 2: Efficacy trials to evaluate therapeutic effects
- Phase 3: Large-scale trials to confirm efficacy and safety
- Phase 4: Post-marketing surveillance for long-term safety and efficacy
| Trial ID | Title | Phase | Status | Sponsor | Indications | Interventions | |
|---|---|---|---|---|---|---|---|
| NCT05702879 | Combined Microbiota and Metabolic Signature in Ulcerative Colitis Predicts Anti-Inflammatory Therapy Success | NULL | UNKNOWN | Insel Gruppe AG, University Hospital Bern | Ulcerative Colitis | DRUG: Ozanimod|DRUG: TNF Inhibitor|DRUG: Steroids… | Details |
| NCT05284136 | Exclusion Diet vs corticosteroIds in patientS With activE Crohn's Disease | PHASE2|PHASE3 | UNKNOWN | Assistance Publique - Hôpitaux de Paris | Crohn Disease | DIETARY_SUPPLEMENT: Crohn's disease exclusion die… | Details |
| NCT04999228 | Top Down Versus Step up in Pediatric Ulcerative Colitis | PHASE4 | RECRUITING | Children's Hospital of Fudan University | Ulcerative Colitis|Infliximab|Children | DRUG: Infliximab|DRUG: Corticosteroids | Details |
| NCT04564638 | Long-term Outcome of Patients With Acute Ulcerative Colitis After First Course of Intravenous Corticosteroids | NULL | COMPLETED | Tampere University Hospital | Ulcerative Colitis | DRUG: Corticosteroid | Details |
| NCT03942861 | Sonographic Assessment in Severe Ulcerative Colitis Patients Admitted for Intravenous Corticosteroids and Eligible for Infliximab Rescue Therapy; a Prospective Clinician-blinded Observational Study Protocol. | NULL | UNKNOWN | Copenhagen University Hospital at Herlev | Ulcerative Colitis|Ultrasound Therapy; Complicati… | DRUG: Solu-Medrol | Details |
| NCT03833596 | Exclusive Enteral Nutrition and Corticosteroids Therapy in Crohn's Disease (EENCD) | PHASE4 | TERMINATED | McMaster University | Crohn's Disease | DRUG: Prednisone|DIETARY_SUPPLEMENT: Exclusive En… | Details |
| NCT03460847 | Fecal Microbiota Alterations in Steroid Refractory Active Colitis Ulcerosa | NULL | COMPLETED | Medical University of Graz | Colitis, Ulcerative | DRUG: Steroids | Details |
| NCT02922374 | Ulcerative Colitis Endoscopic Index of Severity and Fecal Calprotectin to Predict the Reaction to Corticosteroids of Acute Severe Ulcerative Colitis | PHASE1|PHASE2 | UNKNOWN | Jinling Hospital, China | Acute Severe Colitis (ASC) | DRUG: corticosteroids | Details |
| NCT02665845 | Combination Corticosteroids+5-aminosalicylic Acids Compared to Corticosteroids Alone (for Ulcerative Colitis). | PHASE3 | COMPLETED | Centre Hospitalier Universitaire de Saint Etienne | Ulcerative Colitis | DRUG: 5-ASA|DRUG: Corticosteroids | Details |
| NCT02619552 | Impact of Medical Treatment on Sexual Function in Patients With Crohn's Disease | NULL | COMPLETED | University of Maryland, Baltimore | Crohn's Disease|IBD | DRUG: Anti-TNF|DRUG: Anti-TNF|DRUG: Steroids | Details |
| NCT02425852 | A Randomized, Multicenter Open Label Study Comparing Early Administration of Azathioprine Plus IFX to Steroids Plus Azathioprine for Acute Severe Colitis | PHASE4 | COMPLETED | Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives | Ulcerative Colitis | DRUG: Azathioprine|DRUG: Infliximab|DRUG: Prednis… | Details |
| NCT02324699 | Corticosteroids With Vedolizumab in Crohn's Disease | PHASE4 | TERMINATED | Icahn School of Medicine at Mount Sinai | Crohn's Disease | DRUG: Prednisone|DRUG: Placebo|DRUG: Vedolizumab | Details |
| NCT02033408 | Manipulating the Microbiome in IBD by Antibiotics and FMT | NA | COMPLETED | Shaare Zedek Medical Center | Exacerbation of Ulcerative Colitis|Ulcerative Col… | DRUG: AB (antibiotics)|DRUG: CS (corticosteroids)… | Details |
| NCT01941589 | Corticosteroids+5-aminosalicylic Acid Compared to Corticosteroids in the Treatment of Moderate-severe Ulcerative Colitis | PHASE4 | COMPLETED | Sheba Medical Center | Ulcerative Colitis | DRUG: oral 5-ASA+/-topical 5-ASA+IV corticosteroi… | Details |
| NCT01536535 | Predicting Response to Standardized Pediatric Colitis Therapy | PHASE4 | COMPLETED | Connecticut Children's Medical Center | Ulcerative Colitis | DRUG: Mesalazine|DRUG: IV Corticosteroid|DRUG: Or… | Details |
| NCT00702611 | Efficacy Study of Granulocytapheresis Plus Steroids vs Steroids Alone in Active Steroid Dependant Ulcerative Colitis | PHASE4 | TERMINATED | Grupo Espanol de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa | Ulcerative Colitis | DEVICE: Granulocyte Monocyte Apheresis (GMA-Apher… | Details |
| NCT00672763 | Adjuvant Vitamin D With Corticosteroids in Active Crohn's Disease | PHASE4 | WITHDRAWN | Imperial College London | Crohn's Disease | DRUG: Colecalciferol D3 (Vigantol Oil)|DRUG: Medi… | Details |
| NCT00514982 | Medical Treatment of Colitis in Patients With Hermansky-Pudlak Syndrome | PHASE2 | WITHDRAWN | National Institute of Allergy and Infectious Diseases (NIAID) | Hermanski-Pudlak Syndrome|Colitis|Cytokines|Lymph… | DRUG: Mesalamine|DRUG: Infliximab|DRUG: Corticost… | Details |
| NCT00269438 | New Tablet Formulation and Dosing Regimen of Balsalazide Disodium in Mildly to Moderately Active Ulcerative Colitis | PHASE3 | COMPLETED | Bausch Health Americas, Inc. | Ulcerative Colitis | DRUG: 5 ASA, enemas, suppositories, corticosteroi… | Details |
| NCT00265772 | Comparison of a Nutritional Anti-Inflammatory Treatment to Steroids for Pediatric Crohn's Disease - the Molecular Basis | PHASE4 | UNKNOWN | Hôpital Necker-Enfants Malades | Crohn's Disease|Pediatric | DRUG: MODULEN IBD (R) (specific Enteral Nutrition… | Details |
| Disease ID | Disease Name | Definition | Category | Related Drugs | Mechanism | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Strategy ID | Therapeutic Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| S01 | Anti-inflammatory | inflammatory | 5-Aminosalicylates (5-ASAs); corticosteroids | Crohn's disease and ulcerative colitis are the two main com… | Details |
Infliximab as Rescue Therapy for Hospitalized Patients With Crohn's Disease Fai…
PMID: 33201000
Year: 2022
Relationship Type:
Treatment
Score: 10.0
BACKGROUND: Infliximab (IFX) has been shown to be effective rescue therapy for hospitalized ulcerative colitis patients failing intravenous (IV) cort…
Treatment of Ulcerative Colitis with Steroids (in Whom, How Long, What Dose, Wh…
PMID: 33121690
Year: 2020
Relationship Type:
Treatment
Score: 10.0
Corticosteroids are a nonspecific immune modulator used in the treatment of ulcerative colitis. Topical and systemic forms of corticosteroids have be…
Use of steroids to treat anti-tumor necrosis factor α induced tuberculosis-asso…
PMID: 33120729
Year: 2020
Relationship Type:
Treatment
Score: 10.0
INTRODUCTION: Individuals with tuberculosis (TB) who are being treated with anti-tumor necrosis factor alpha (anti-TNFalpha) for coexisting condition…
Self-medication with oral corticosteroids reported by patients with ulcerative …
PMID: 32956185
Year: 2021
Relationship Type:
Association
Score: 10.0
BACKGROUND: Few studies have examined self-medication with corticosteroids among patients with ulcerative colitis (UC). AIMS: To assess the frequency…
A Rare Case Report and Literature Review of Anabolic-Androgenic Steroids (AAS)-…
PMID: 32617209
Year: 2020
Relationship Type:
Adverse Effect
Score: 10.0
Anabolic-androgenic steroids (AAS) abuse is common in competitive athletes in order to enhance athletic performances. However, AAS abuse is often ass…
Effect of Concomitant Therapy With Steroids and Tumor Necrosis Factor Antagonis…
PMID: 32569749
Year: 2021
Relationship Type:
Treatment
Score: 10.0
BACKGROUND: Reports on the feasibility and effectiveness of translating proactive, antitumor necrosis factor (TNF) therapeutic drug monitoring (TDM)…
Long-term outcome of patients with acute severe ulcerative colitis responding t…
PMID: 32342994
Year: 2020
Relationship Type:
Treatment
Score: 10.0
BACKGROUND: The long-term outcome of patients with acute severe ulcerative colitis (ASUC) responding to intravenous steroids (IVS) has been poorly re…
Corticosteroids Prior to Embryo Transfer in Assisted Reproduction in Women with…
PMID: 32256120
Year: 2020
Relationship Type:
Treatment
Score: 10.0
PURPOSE: Former studies have suggested that women with Crohn's disease (CD) and ulcerative colitis (UC) have a decreased chance of a live born child …
[PREMEDICATION WITH CORTICOSTEROIDS PRIOR TO IV INFLIXIMAB - A COMPARISON BETWE…
PMID: 31507106
Year: 2019
Relationship Type:
Treatment
Score: 10.0
INTRODUCTION: Infliximab is a protein with an anti TNF-alpha activity which is given in an intra-venous manner to treat inflammatory bowel disease an…
Premedication with corticosteroids does not impact the pharmacokinetics of infl…
PMID: 31094854
Year: 2019
Relationship Type:
Treatment
Score: 10.0
OBJECTIVE: Loss of infliximab (IFX) effect is a clinical challenge in the management of patients with Crohn's disease (CD), but this can potentially …
Single-Needle Intensive Granulocyte and Monocyte Adsorptive Apheresis Is Suitab…
PMID: 31025824
Year: 2019
Relationship Type:
Treatment
Score: 10.0
Twice-weekly intensive granulocyte/monocyte adsorptive apheresis is effective and safe for ulcerative colitis, but maintaining two blood access route…
A probable case of catastrophic antiphospholipid syndrome: Should high-dose ste…
PMID: 30967955
Year: 2019
Relationship Type:
Treatment
Score: 10.0
In this clinical vignette, we present a case of a 59-year-old woman with catastrophic antiphospholipid syndrome likely triggered by polymicrobial sep…
Exclusive enteral nutrition versus corticosteroids for treatment of pediatric C…
PMID: 30666565
Year: 2019
Relationship Type:
Treatment
Score: 10.0
BACKGROUND: Many studies have examined the effects of exclusive enteral nutrition (EEN) in children with Crohn's disease (CD), but corticosteroids ar…
Vedolizumab in Combination With Corticosteroids for Induction Therapy in Crohn'…
PMID: 30615117
Year: 2019
Relationship Type:
Treatment
Score: 10.0
BACKGROUND: Combined therapy with vedolizumab and corticosteroids may improve clinical response or remission in Crohn's disease. The aim of this stud…
Differences in Outcomes Over Time With Exclusive Enteral Nutrition Compared Wit…
PMID: 29165666
Year: 2018
Relationship Type:
Association
Score: 10.0
BACKGROUND: Exclusive enteral nutrition [EEN] and corticosteroids [CS] induce similar rates of remission in mild to moderate paediatric Crohn's disea…
Combined use of high doses of vasopressin and corticosteroids in a patient with…
PMID: 29129185
Year: 2017
Relationship Type:
Treatment
Score: 10.0
BACKGROUND: In this article, we present a clinical case of refractory septic shock resulting from intestinal perforation treated with high doses of v…
Long-interval Cytapheresis as a Novel Therapeutic Strategy Leading to Dosage Re…
PMID: 28924114
Year: 2017
Relationship Type:
Treatment
Score: 10.0
Objective This study was performed to confirm the efficacy of long-interval cytapheresis on steroid-dependent ulcerative colitis (UC). Methods To dis…
Do we know how to use corticosteroids in acute severe ulcerative colitis?
PMID: 28839676
Year: 2012
Relationship Type:
Treatment
Score: 10.0
Options for the treatment of acute severe ulcerative colitis have broadened with the use of ciclosporin and infliximab, but corticosteroids remain fi…
Exclusive Enteral Nutrition Therapy in Paediatric Crohn's Disease Results in Lo…
PMID: 28575325
Year: 2017
Relationship Type:
Treatment
Score: 10.0
BACKGROUND AND AIMS: Exclusive enteral nutrition [EEN] is recommended as a first-line induction therapy for paediatric Crohn's disease [CD] although …
Fecal calprotectin as an alternative to ulcerative colitis endoscopic index of …
PMID: 28539226
Year: 2017
Relationship Type:
Treatment
Score: 10.0
BACKGROUND: Fecal calprotectin (FC) might be an alternative to ulcerative colitis endoscopic index of severity (UCEIS) to predict the response to cor…