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Current and future microbiome-based therapies in inflammatory bowel disease
Publication Year: 2024 Source: Curr Opin Gastroenterol PMID: 38841848 DOI: 10.1097/MOG.0000000000001027
PURPOSE OF REVIEW: The role of the microbiome and dysbiosis is increasingly recognized in the pathogenesis of inflammatory bowel disease (IBD). Intestinal microbiota transplant (IMT), previously termed fecal microbiota transplant has demonstrated efficacy in restoring a healthy microbiome and promoting gut health in recurrent Clostridioides difficile infection. Several randomized trials …
Antigenic operon fragmentation and diversification mechanism in Bacteroidota impacts gut metagenomics and pathobionts in Crohn's disease microlesions
Publication Year: 2024 Source: Gut Microbes PMID: 38841888
No Abstract
Inflammatory bowel disease training assessment of gastroenterology fellows in Saudi Arabia
Publication Year: 2024 Source: Saudi J Gastroenterol PMID: 38841910 DOI: 10.4103/sjg.sjg_19_24
BACKGROUND: Recent advancement and complexity in the management of inflammatory bowel disease (IBD) has made it challenging for gastroenterology (GI) fellows to obtain competency and confidence in managing the complex IBD patient. We aimed to evaluate the confidence and training in IBD among GI fellows in Saudi Arabia. METHODS: We …
Serum Metabolites Relate to Mucosal and Transmural Inflammation in Paediatric Crohn Disease
Publication Year: 2024 Source: J Crohns Colitis PMID: 38842257
No Abstract
Characterization of patient-derived intestinal organoids for modelling fibrosis in Inflammatory Bowel Disease
Publication Year: 2024 Source: Inflamm Res PMID: 38842554 DOI: 10.1007/s00011-024-01901-9
BACKGROUND AND AIMS: Intestinal fibrosis is a common complication of Inflammatory Bowel Disease (IBD), namely Crohn's disease (CD) and ulcerative colitis (UC), but the precise mechanism by which it occurs is incompletely understood hampering the development of effective therapeutic strategies. Here, we aimed at inducing and characterizing an inflammation-mediated fibrosis …
Active Inflammatory Bowel Disease Is Associated with Short Sleep Duration via Objective Measures
Publication Year: 2024 Source: Dig Dis Sci PMID: 38842741 DOI: 10.1007/s10620-024-08485-8
INTRODUCTION: Poor sleep quality has been associated with inflammatory bowel disease (IBD) activity, although studies incorporating actigraphy suggest that the perception of sleep differs rather than objective difference in sleep quality. Short sleep duration has been associated with increased pro-inflammatory cytokines that have been implicated in the pathogenesis of IBD. …
TL1A Promotes Fibrogenesis in Colonic Fibroblasts via the TGF-β1/Smad3 Signaling Pathway
Publication Year: 2024 Source: Curr Med Sci PMID: 38842774 DOI: 10.1007/s11596-024-2875-1
OBJECTIVE: Intestinal fibrosis is a refractory complication of inflammatory bowel disease (IBD). Tumor necrosis factor ligand-related molecule-1A (TL1A) is important for IBD-related intestinal fibrosis in a dextran sodium sulfate (DSS)-induced experimental colitis model. This study aimed to explore the effects of TL1A on human colonic fibroblasts. METHODS: A trinitrobenzene sulfonic …
Long-term clinical outcomes of bariatric surgery in adults with severe obesity: A population-based retrospective cohort study
Publication Year: 2024 Source: PLoS One PMID: 38843138
No Abstract
Development of Luminescent Biosensors for Calprotectin
Publication Year: 2024 Source: ACS Chem Biol PMID: 38843544 DOI: 10.1021/acschembio.4c00265
Calprotectin, a metal ion-binding protein complex, plays a crucial role in the innate immune system and has gained prominence as a biomarker for various intestinal and systemic inflammatory and infectious diseases, including inflammatory bowel disease (IBD) and tuberculosis (TB). Current clinical testing methods rely on enzyme-linked immunosorbent assays (ELISAs), limiting …
Prevalence and clinical profiles of primary sclerosing cholangitis in China: Data from electronic medical records and systematic literature retrieval
Publication Year: 2024 Source: J Autoimmun PMID: 38843578 DOI: 10.1016/j.jaut.2024.103264
BACKGROUND & AIMS: Epidemiology of primary sclerosing cholangitis (PSC) is lacking in China. We aimed to estimate the period prevalence and depict the clinical features of PSC in China. METHODS: We identified and included PSC cases between 2000 and 2023 from two sources: electronic medical records (EMR) and systematical literature …
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