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History and Familial Aggregation of Immune-Mediated Diseases in Sarcoidosis: A Register-Based Case-Control-Family Study
Publication Year: 2024 Source: Chest PMID: 38857779
No Abstract
Patient-derived organoid biobank identifies epigenetic dysregulation of intestinal epithelial MHC-I as a novel mechanism in severe Crohn's Disease
Publication Year: 2024 Source: Gut PMID: 38857990
No Abstract
Brain network topological changes in inflammatory bowel disease: an exploratory study
Publication Year: 2024 Source: Eur J Neurosci PMID: 38858102 DOI: 10.1111/ejn.16442
Although the aetio-pathogenesis of inflammatory bowel diseases (IBD) is not entirely clear, the interaction between genetic and adverse environmental factors may induce an intestinal dysbiosis, resulting in chronic inflammation having effects on the large-scale brain network. Here, we hypothesized inflammation-related changes in brain topology of IBD patients, regardless of the …
Seeing is believing: a breakthrough to visualize necrosomes in the tissue
Publication Year: 2024 Source: EMBO Mol Med PMID: 38858536
No Abstract
Ge-Gen-Qin-Lian decoction alleviates the symptoms of type 2 diabetes mellitus with inflammatory bowel disease via regulating the AGE-RAGE pathway
Publication Year: 2024 Source: BMC Complement Med Ther PMID: 38858747 DOI: 10.1186/s12906-024-04526-x
BACKGROUND: This study aimed to explore the mechanism of Ge-Gen-Qin-Lian decoction (GGQLD) in the alleviation of symptoms of type 2 diabetes mellitus (T2DM) with inflammatory bowel disease (IBD) by network pharmacology and experimental validation. METHODS: The active components and targets of GGQLD were identified from the TCMSP database. The potential …
Short-term outcomes of surgical treatment for primary ileocaecal Crohn's disease: Results of the Crohn's(urg) study, a multicentre, retrospective, comparative analysis between inflammatory and complicated phenotypes
Publication Year: 2024 Source: Colorectal Dis PMID: 38858815
No Abstract
Treatment of inflammatory bowel disease with steroid-sparing medications is age-dependent - Results from a Danish nationwide cohort study, 2000-2018
Publication Year: 2024 Source: Aliment Pharmacol Ther PMID: 38859674 DOI: 10.1111/apt.18106
BACKGROUND: Paediatric-onset and elderly-onset inflammatory bowel disease (IBD) present unique treatment challenges. AIMS: We investigated treatment patterns following a first and second course of systemic steroids in paediatric- and elderly-onset IBD and compared them to adult-onset IBD. METHODS: All patients diagnosed with Crohn's disease (CD) or ulcerative colitis (UC) between …
A Rare Case of Drug-Induced Sweet Syndrome After Pembrolizumab Therapy
Publication Year: 2024 Source: Cureus PMID: 38859947
No Abstract
The association between circulating leukocytes and inflammatory bowel disease: a two-sample Mendelian randomization study
Publication Year: 2024 Source: Front Med (Lausanne) PMID: 38860205 DOI: 10.3389/fmed.2024.1399658
BACKGROUND: Inflammatory bowel disease (IBD) is a highly prevalent, recurrent, chronic intestinal inflammatory disease. Several observational studies have shown that circulating leukocytes are strongly associated with IBD. However, whether alterations in leukocytes are causally related to IBD remains uncertain. The present study explores this issue with the Mendelian randomization (MR) …
Synthesis and biological evaluation of chrysin derivatives containing α-lipoic acid for the treatment of inflammatory bowel disease
Publication Year: 2024 Source: Front Chem PMID: 38860236 DOI: 10.3389/fchem.2024.1406051
This study introduces newly discovered chrysin derivatives that show potential as candidate molecules for treating inflammatory bowel disease (IBD). Compound 4b, among the synthesized compounds, displayed significant inhibitory effects on monocyte adhesion to colon epithelium induced by TNF-alpha, with an IC(50) value of 4.71 muM. Further mechanistic studies demonstrated that …
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