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Reversal Surgery for Split Stoma with Peristomal Incision is Associated with Improved Postoperative Outcome in Patients with Crohn's Disease
Publication Year: 2024 Source: J Invest Surg PMID: 38862416
No Abstract
Circadian time-dependent effects of experimental colitis on theophylline disposition and toxicity
Publication Year: 2024 Source: Br J Pharmacol PMID: 38862812 DOI: 10.1111/bph.16440
BACKGROUND AND PURPOSE: Drug disposition undergoes significant alteration in patients with inflammatory bowel disease (IBD), yet circadian time-dependency of these changes remains largely unexplored. In this study, we aimed to determine the temporal effects of experimental colitis on drug disposition and toxicity. EXPERIMENTAL APPROACH: RNA-sequencing was used to screen genes …
Network meta-analysis: Comparative onset of early effect of biologics and small molecules in moderately to severely active luminal Crohn's disease
Publication Year: 2024 Source: Aliment Pharmacol Ther PMID: 38863153
No Abstract
Population Pharmacokinetic and Exposure-Response Modeling to Inform Risankizumab Dose Selection in Patients With Ulcerative Colitis
Publication Year: 2024 Source: Clin Pharmacol Ther PMID: 38863178
No Abstract
Bowel-associated dermatosis-arthritis syndrome, a diagnostic challenge in a young child with very early-onset inflammatory bowel disease
Publication Year: 2024 Source: Pediatr Dermatol PMID: 38863220 DOI: 10.1111/pde.15637
A 14-month-old girl with very early-onset inflammatory bowel disease (VEO-IBD) was admitted with a flare of her bowel disease and subsequently developed high fevers, joint pain, and skin lesions during her hospitalization. Workup demonstrated bowel-associated dermatosis-arthritis syndrome in the setting of VEO-IBD, a neutrophilic dermatosis rarely reported in children that …
Synthetically Feasible De Novo Molecular Design of Leads Based on a Reinforcement Learning Model: AI-Assisted Discovery of an Anti-IBD Lead Targeting CXCR4
Publication Year: 2024 Source: J Med Chem PMID: 38863440 DOI: 10.1021/acs.jmedchem.4c00184
Artificial intelligence (AI) de novo molecular generation provides leads with novel structures for drug discovery. However, the target affinity and synthesizability of the generated molecules present critical challenges for the successful application of AI technology. Therefore, we developed an advanced reinforcement learning model to bridge the gap between the theory …
Insights into disability and psycho-social care of patients with inflammatory bowel disease
Publication Year: 2024 Source: Front Med (Lausanne) PMID: 38863889 DOI: 10.3389/fmed.2024.1416054
In recent years, the concept of disability has increasingly garnered attention as a crucial long-term target of inflammatory bowel disease (IBD) management. The treatment paradigm has changed dramatically from full control of the disease (clinical and endoscopic remission) toward physical and emotional well-being with the goal of preventing disability and …
The emerging role of T helper 9 (Th9) cells in immunopathophysiology: A comprehensive review of their effects and responsiveness in various disease states
Publication Year: 2024 Source: Int Rev Immunol PMID: 38864109
No Abstract
Timing Is Everything: The Lifesaving Potential of Early Medical Therapy in Acute Severe Ulcerative Colitis
Publication Year: 2024 Source: Am J Gastroenterol PMID: 38864521
No Abstract
Baseline Assessment of Serum Cytokines Predicts Clinical and Endoscopic Response to Ustekinumab in Patients With Crohn's Disease: A Prospective Pilot Study
Publication Year: 2024 Source: Inflamm Bowel Dis PMID: 38864707
No Abstract
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