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Identification of master regulator genes controlling pathogenic CD4(+) T cell fate in inflammatory bowel disease through transcriptional network analysis
Publication Year: 2024 Source: Sci Rep PMID: 38719901 DOI: 10.1038/s41598-024-61158-4
Inflammatory bowel diseases (IBD) are a group of chronic inflammatory conditions of the gastrointestinal tract associated with multiple pathogenic factors, including dysregulation of the immune response. Effector CD4(+) T cells and regulatory CD4(+) T cells (Treg) are central players in maintaining the balance between tolerance and inflammation. Interestingly, genetic modifications …
Neutrophil-derived PAD4 induces citrullination of CKMT1 exacerbates mucosal inflammation in inflammatory bowel disease
Publication Year: 2024 Source: Cell Mol Immunol PMID: 38720063 DOI: 10.1038/s41423-024-01158-6
Peptidyl arginine deiminase 4 (PAD4) plays a pivotal role in infection and inflammatory diseases by facilitating the formation of neutrophil extracellular traps (NETs). However, the substrates of PAD4 and its exact role in inflammatory bowel disease (IBD) remain unclear. In this study, we employed single-cell RNA sequencing (scRNA-seq) and substrate …
Using preoperative C-reactive protein levels to predict anastomotic leaks and other complications after elective colorectal surgery: A systematic review and meta-analysis
Publication Year: 2024 Source: Colorectal Dis PMID: 38720514
No Abstract
Polyphenolic Nanoparticle-Modified Probiotics for Microenvironment Remodeling and Targeted Therapy of Inflammatory Bowel Disease
Publication Year: 2024 Source: ACS Nano PMID: 38720520 DOI: 10.1021/acsnano.4c00830
Inflammatory bowel diseases (IBDs) refer to multifaceted disorders in the intestinal microenvironment and microbiota homeostasis. In view of the broad bioactivity and high compatibility of polyphenols, there is considerable interest in developing a polyphenol-based collaborative platform to remodel the IBD microenvironment and regulate microbiota. Here, we demonstrated the coordination assembly …
Faecal Transplantation for Ulcerative Colitis From Diet Conditioned Donors Followed by Dietary Intervention Results in Favourable Gut Microbial Profile Compared to Faecal Transplantation Alone
Publication Year: 2024 Source: J Crohns Colitis PMID: 38720628
No Abstract
Causal relationship between eosinophilic esophagitis and inflammatory bowel disease: a bidirectional two-sample Mendelian randomization study
Publication Year: 2024 Source: Front Immunol PMID: 38720886 DOI: 10.3389/fimmu.2024.1374107
BACKGROUND: Eosinophilic esophagitis (EoE) and inflammatory bowel diseases (IBDs), including Crohn's disease (CD) and ulcerative colitis (UC), are immune-mediated gastrointestinal diseases with overlapped pathogenesis and are sometimes concurrently diagnosed, but their causal relationship remains unclear. We investigated the causal relationship between EoE and IBD and its subtypes via a two-sample …
The two-directional prospective association between inflammatory bowel disease and neurodegenerative disorders: a systematic review and meta-analysis based on longitudinal studies
Publication Year: 2024 Source: Front Immunol PMID: 38720896 DOI: 10.3389/fimmu.2024.1325908
OBJECTIVE: Previous studies reported possible connections between inflammatory bowel disease (IBD) and several neurodegenerative disorders. However, the comprehensive relationships between IBD and various neurodegenerative disorders were not summarized. We executed a meta-analysis of longitudinal studies to provide an estimate of the strength of the two-directional prospective association between IBD and …
Research progress of autoimmune diseases based on induced pluripotent stem cells
Publication Year: 2024 Source: Front Immunol PMID: 38720903
No Abstract
Clinical Decision Making in Inflammatory Bowel Disease Mimics: Practice Management from Inflammatory Bowel Disease LIVE
Publication Year: 2024 Source: Crohns Colitis 360 PMID: 38720935 DOI: 10.1093/crocol/otae022
BACKGROUND: Since 2009, inflammatory bowel disease (IBD) specialists have utilized "IBD LIVE," a weekly live video conference with a global audience, to discuss the multidisciplinary management of their most challenging cases. While most cases presented were confirmed IBD, a substantial number were diseases that mimic IBD. We have categorized all …
Strategies for Enhancing Inflammatory Bowel Disease Care in Pakistan: Bridging Gaps and Building Capacities
Publication Year: 2024 Source: Crohns Colitis 360 PMID: 38720936 DOI: 10.1093/crocol/otae027
No Abstract
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