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Infliximab Tissue Concentrations in Patients With Stable Ulcerative Colitis Are Correlated With More Durable Infliximab-associated Disease Remission
Publication Year: 2024 Source: Inflamm Bowel Dis PMID: 38717841
No Abstract
Oncostatin M Induces a Pro-inflammatory Phenotype in Intestinal Subepithelial Myofibroblasts
Publication Year: 2024 Source: Inflamm Bowel Dis PMID: 38717842 DOI: 10.1093/ibd/izae098
BACKGROUND: Oncostatin-M (OSM) is associated with antitumor necrosis factor (anti-TNF)-alpha resistance in inflammatory bowel disease (IBD) and fibrosis in inflammatory diseases. We studied the expression of OSM and its receptors (OSMR, gp130) on intestinal subepithelial myofibroblasts (SEMFs) and the effect of OSM stimulation on SEMFs. METHODS: The mRNA and protein …
Design, synthesis, and biological evaluation of novel sesquiterpene lactone derivatives as PKM2 activators with potent anti-ulcerative colitis activities
Publication Year: 2024 Source: Eur J Med Chem PMID: 38718622
No Abstract
mTOR promotes an inflammatory response through the HIF1 signaling pathway in ulcerative colitis
Publication Year: 2024 Source: Int Immunopharmacol PMID: 38718658
No Abstract
Leitlinienreport der aktualisierten S3-Leitlinie Colitis ulcerosa der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS)
Publication Year: 2024 Source: Z Gastroenterol PMID: 38718807
No Abstract
Aktualisierte S3-Leitlinie Colitis ulcerosa (Version 6.2)
Publication Year: 2024 Source: Z Gastroenterol PMID: 38718808
No Abstract
Orally ingestible medication utilizing layered double hydroxide nanoparticles strengthened alginate and hyaluronic acid-based hydrogel bead for bowel disease management
Publication Year: 2024 Source: Int J Biol Macromol PMID: 38718992
No Abstract
17β-estradiol promotes myeloid-derived suppressor cells functions and alleviates inflammatory bowel disease by activation of Stat3 and NF-κB signalings
Publication Year: 2024 Source: J Steroid Biochem Mol Biol PMID: 38719162 DOI: 10.1016/j.jsbmb.2024.106540
Inflammatory bowel disease (IBD) describes a group of clinically common autoimmune diseases characterized by chronic intestinal inflammation, with gender differences in prevalence. Estrogen has been previously shown to exert anti-inflammatory action in IBD development, however, the mechanisms remain obscure. Recent research has revealed that myeloid-derived suppressor cells (MDSCs) play a …
Effects of prednisolone tapering on effectiveness of infliximab in patients with ulcerative colitis: data from a retrospective cohort
Publication Year: 2024 Source: BMJ Open Gastroenterol PMID: 38719549 DOI: 10.1136/bmjgast-2024-001343
BACKGROUND AND OBJECTIVE: The influence of concomitant prednisolone on clinical outcomes and safety in infliximab-treated ulcerative colitis (UC) patients is unknown. DESIGN, SETTING, PARTICIPANTS AND OUTCOME MEASURES: A retrospective cohort study was performed, including 147 UC patients treated with infliximab at a tertiary inflammatory bowel disease (IBD) centre. Primary outcome …
The histopathology of very early onset-IBD
Publication Year: 2024 Source: Dig Liver Dis PMID: 38719629 DOI: 10.1016/j.dld.2024.04.020
No Abstract
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