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Readily Available Oral Prebiotic Protein Reactive Oxygen Species Nanoscavengers for Synergistic Therapy of Inflammation and Fibrosis in Inflammatory Bowel Disease
Publication Year: 2024 Source: ACS Nano PMID: 38740518 DOI: 10.1021/acsnano.3c13114
A significant gap exists in the demand for safe and effective drugs for inflammatory bowel disease (IBD), and its associated intestinal fibrosis. As oxidative stress plays a central role in the pathogenesis of IBD, astaxanthin (AST), a good antioxidant with high safety, holds promise for treating IBD. However, the application …
The impact of vedolizumab therapy on extraintestinal manifestations in patients with inflammatory bowel disease: A systematic review and meta-analysis
Publication Year: 2024 Source: J Gastroenterol Hepatol PMID: 38740543 DOI: 10.1111/jgh.16612
BACKGROUND AND AIM: Extraintestinal manifestations (EIMs) pose a significant threat in inflammatory bowel disease (IBD) patients. Vedolizumab (VDZ) primarily affects the gastrointestinal tract. However, its impact on EIMs remains uncertain. Therefore, we conducted this meta-analysis to examine the effects of VDZ on EIMs during treatment. METHODS: Relevant studies were identified …
Influence of hospital-level and surgeon factors on the outcomes after ileo-anal pouch surgery for inflammatory bowel disease: systematic review
Publication Year: 2024 Source: Br J Surg PMID: 38740552
No Abstract
Dynamic changes in extracellular vesicle-associated miRNAs elicited by ultrasound in inflammatory bowel disease patients
Publication Year: 2024 Source: Sci Rep PMID: 38740826 DOI: 10.1038/s41598-024-61532-2
Blood-based biomarkers that reliably indicate disease activity in the intestinal tract are an important unmet need in the management of patients with IBD. Extracellular vesicles (EVs) are cell-derived membranous microparticles, which reflect the cellular and functional state of their site of site of origin. As ultrasound waves may lead to …
Mitochondrial function and gastrointestinal diseases
Publication Year: 2024 Source: Nat Rev Gastroenterol Hepatol PMID: 38740978
No Abstract
Portal vein thrombosis as extraintestinal complications of Crohn's disease: a case report and review of literature
Publication Year: 2024 Source: J Med Case Rep PMID: 38741148
No Abstract
Is the European Crohn's and Colitis organisation (ECCO) e-guide an acceptable and feasible tool for increasing gastroenterologists' guideline adherence? A mixed methods evaluation
Publication Year: 2024 Source: BMC Med Educ PMID: 38741179
No Abstract
The landscape of rare genetic variation associated with inflammatory bowel disease and Parkinson's disease comorbidity
Publication Year: 2024 Source: Genome Med PMID: 38741190 DOI: 10.1186/s13073-024-01335-2
BACKGROUND: Inflammatory bowel disease (IBD) and Parkinson's disease (PD) are chronic disorders that have been suggested to share common pathophysiological processes. LRRK2 has been implicated as playing a role in both diseases. Exploring the genetic basis of the IBD-PD comorbidity through studying high-impact rare genetic variants can facilitate the identification …
Management of Colorectal Neoplasia in IBD Patients: Current Practice and Future Perspectives
Publication Year: 2024 Source: J Crohns Colitis PMID: 38741227 DOI: 10.1093/ecco-jcc/jjae071
Inflammatory bowel disease [IBD] patients are at increased risk of developing colorectal neoplasia [CRN]. In this review, we aim to provide an up-to-date overview and future perspectives on CRN management in IBD. Advances in endoscopic surveillance and resection techniques have resulted in a shift towards endoscopic management of neoplastic lesions …
Beyond the bowel: Wernicke's encephalopathy as a neurological complication of Crohn's disease: A case report
Publication Year: 2024 Source: Radiol Case Rep PMID: 38741688 DOI: 10.1016/j.radcr.2024.03.088
Wernicke encephalopathy (WE) is a rare but severe neurological syndrome characterized, in its classic form, by the acute onset of ocular disturbances, ataxia, and cognitive impairment. It is caused by a deficiency of thiamine (vitamin B1) and mainly affects chronic alcoholics, although it can also affect patients with pathologies that …
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