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Cyclophosphamide-free Mobilisation Increases Safety While Preserving the Efficacy of Autologous Haematopoietic Stem Cell Transplantation in Refractory Crohn's Disease Patients
Publication Year: 2024 Source: J Crohns Colitis PMID: 38757210
No Abstract
What is the rate of definitive stoma after subtotal colectomy for inflammatory bowel disease? A nationwide study of 1860 patients
Publication Year: 2024 Source: Colorectal Dis PMID: 38757256 DOI: 10.1111/codi.17020
AIM: Some patients with inflammatory bowel disease (IBD) require subtotal colectomy (STC) with ileostomy. The recent literature reports a significant number of patients who do not undergo subsequent surgery and are resigned to living with a definitive stoma. The aim of this work was to analyse the rate of definitive …
IFIH1 loss of function predisposes to inflammatory and SARS-CoV-2-related infectious diseases
Publication Year: 2024 Source: Scand J Immunol PMID: 38757311
No Abstract
Combined or High Dose Immunosuppression in Inflammatory Bowel Disease patients who are NUDT15 Homozygous Harbors Risk of Developing Invasive Fungal Infections: A Case Series
Publication Year: 2024 Source: Inflamm Bowel Dis PMID: 38757903
No Abstract
Translational Utility of Organoid Models for Biomedical Research on Gastrointestinal Diseases
Publication Year: 2024 Source: Stem Cell Rev Rep PMID: 38758462 DOI: 10.1007/s12015-024-10733-3
Organoid models have recently been utilized to study 3D human-derived tissue systems to uncover tissue architecture and adult stem cell biology. Patient-derived organoids unambiguously provide the most suitable in vitro system to study disease biology with the actual genetic background. With the advent of much improved and innovative approaches, patient-derived …
Serum Extracellular Matrix Molecules and Their Fragments as Biomarkers of Inflammation and Fibrosis in Inflammatory Bowel Diseases: A Systematic Review
Publication Year: 2024 Source: J Crohns Colitis PMID: 38758527 DOI: 10.1093/ecco-jcc/jjae077
BACKGROUND AND AIM: Contemporary techniques to assess disease activity or bowel damage in patients with inflammatory bowel disease [IBD], such as endoscopy and imaging, are either invasive or lack accuracy. Non-invasive biomarkers for this purpose remain an unmet medical need. Herein, we provide a comprehensive systematic review of studies evaluating …
Exploration of the molecular linkage between endometriosis and Crohn disease by bioinformatics methods
Publication Year: 2024 Source: Medicine (Baltimore) PMID: 38758892
No Abstract
Identification and characteristics of patients with potential difficult-to-treat psoriatic arthritis: exploratory analyses of the Greek PsA registry
Publication Year: 2024 Source: Rheumatology (Oxford) PMID: 38759119 DOI: 10.1093/rheumatology/keae263
OBJECTIVE: To present the characteristics of patients with potential difficult-to-treat (D2T) PsA. METHODS: We used data from the Greek multicentre registry of PsA patients. D2T PsA was defined as follows: patients with at least 6 months' disease duration, who have failed to at least one conventional synthetic DMARD and at …
Narirutin mitigates dextrose sodium sulfate-induced colitis in mice by modulating intestinal flora
Publication Year: 2024 Source: Phytomedicine PMID: 38759313
No Abstract
Design, synthesis and bioactivity evaluation of 4-hydroxycoumarin derivatives as potential anti-inflammatory agents against acute lung injury and colitis
Publication Year: 2024 Source: Eur J Med Chem PMID: 38759452 DOI: 10.1016/j.ejmech.2024.116487
Acute lung injury (ALI) and inflammatory bowel disease (IBD) are common inflammatory illnesses that seriously affect people's health. Herein, a series of 4-hydroxylcoumarin (4-HC) derivatives were designed and synthesized. The inhibitory effects of these compounds on LPS-induced interleukin-6 (IL-6) release from J774A.1 cells were then screened via ELISA assay, compound …
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