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Treatment endpoints in ulcerative colitis: Does one size fit all?
Publication Year: 2024 Source: World J Gastrointest Pharmacol Ther PMID: 38764502 DOI: 10.4292/wjgpt.v15.i2.91591
A treat-to-target strategy in inflammatory bowel disease (IBD) involves treatment intensification in order to achieve a pre-determined endpoint. Such uniform and tight disease control has been demonstrated to improve clinical outcomes compared to treatment driven by a clinician's subjective assessment of symptoms. However, choice of treatment endpoints remains a challenge …
Prevalence of Classical Extraintestinal Manifestations among Inflammatory Bowel Disease Patients in Saudi Arabia: A Single Tertiary Center Experience
Publication Year: 2024 Source: Saudi J Med Med Sci PMID: 38764558 DOI: 10.4103/sjmms.sjmms_139_23
BACKGROUND: Patients with inflammatory bowel disease (IBD) may also experience extraintestinal manifestations (EIMs), which can affect various organ systems, and their occurrence is based on disease activity. OBJECTIVES: To determine the prevalence of EIMs and their most common types among IBD patients from Saudi Arabia. MATERIALS AND METHODS: This retrospective …
Differential Manifestations of Inflammatory Bowel Disease Based on Race and Immigration Status
Publication Year: 2024 Source: Gastro Hep Adv PMID: 38765199 DOI: 10.1016/j.gastha.2023.11.021
BACKGROUND AND AIMS: The prevalence of inflammatory bowel disease (IBD) is increasing globally. In this context, identifying risk factors for severe disease is important. We examined how race/ethnicity and immigration status influence IBD manifestations, treatments, and outcomes in a diverse, tertiary-care safety-net hospital. METHODS: We conducted a single-center retrospective review …
Patient Advocates for Clinical Research (PACER): A Step Toward Ethical, Relevant, and Truly Participatory Clinical Research in India
Publication Year: 2024 Source: Cureus PMID: 38765448
No Abstract
Phasing millions of samples achieves near perfect accuracy, enabling parent-of-origin classification of variants
Publication Year: 2024 Source: bioRxiv PMID: 38766004 DOI: 10.1101/2024.05.06.592816
Haplotype phasing, the process of determining which genetic variants are physically located on the same chromosome, is crucial for various genetic analyses. In this study, we first benchmark SHAPEIT and Beagle, two state-of-the-art phasing methods, on two large datasets: > 8 million diverse, research-consented 23andMe, Inc. customers and the UK …
The Mediating and Moderating Role of Resilience Between Stigma and Illness Identity Among People with Inflammatory Bowel Disease
Publication Year: 2024 Source: Psychol Res Behav Manag PMID: 38766316 DOI: 10.2147/PRBM.S452002
BACKGROUND: Stigma is assumed to lead to negative illness identity in one who got chronic illness, and there is a lack of understanding regarding the underly mechanisms. However, no research has examined the extent to which stigma was associated with illness identity in people with IBD. Therefore, we investigated the …
Sleep Patterns, Pain, and Emotional Functioning in Youth with Inflammatory Bowel Disease
Publication Year: 2024 Source: Clin Pract Pediatr Psychol PMID: 38766379 DOI: 10.1037/cpp0000491
OBJECTIVE: Youth with inflammatory bowel disease (IBD) may be at increased risk for sleep difficulties due to the painful and inflammatory nature of their disease. Moreover, children and adolescents with IBD experience impairment across a variety of psychosocial domains. However, researchers have yet to investigate the complex interplay between sleep, …
A prediction of the CRNDE role by modulating NF-κB pathway in inflammatory bowel disease (IBD)
Publication Year: 2024 Source: Biochem Biophys Rep PMID: 38766384 DOI: 10.1016/j.bbrep.2024.101731
Long non-coding RNAs (lncRNAs) regulate multiple pathways and cellular mechanisms. Recent research has emphasized their involvement in the pathogenesis of complex diseases, such as Inflammatory Bowel Disease (IBD) which is characterized by chronic inflammation of the intestines. The two most common types of IBD are ulcerative colitis and Crohn's disease. …
Impact of inflammatory bowel disease on women's reproductive life: a questionnaire-based study
Publication Year: 2024 Source: Therap Adv Gastroenterol PMID: 38766477 DOI: 10.1177/17562848241249440
BACKGROUND: Inflammatory bowel diseases (IBDs) have a peak incidence between the second and fourth decades of life and can affect women's reproductive life. OBJECTIVES: Our study aimed to assess the impact of IBD on the reproductive life of female patients with this condition. DESIGN: Cross-sectional study. METHODS: Women with IBD …
Endoscopic therapy of stoma closure site strictures in ileal pouches is safe and effective
Publication Year: 2024 Source: Gastroenterol Rep (Oxf) PMID: 38766493 DOI: 10.1093/gastro/goae038
BACKGROUND: Strictures are a common complication after ileal pouch surgery with the most common locations being at the anastomosis, pouch inlet, and stoma closure site. No previous literature has described endoscopic therapy of stoma site stricture. This study aimed to assess the safety and efficacy of endoscopic therapy in the …
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