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Clinical validation and accuracy assessment of the Capsule Endoscopy-Crohn's Disease index (CE-CD)
Publication Year: 2024 Source: J Pediatr Gastroenterol Nutr PMID: 38775018
No Abstract
ADHERENCE AND PERSISTENCE TO TREATMENT WITH INFLIXIMAB: ANALYSIS OF A PATIENT SUPPORT PROGRAM COHORT IN BRAZIL
Publication Year: 2024 Source: Arq Gastroenterol PMID: 38775584 DOI: 10.1590/S0004-2803.24612023-149
BACKGROUND: Monoclonal antibodies have proven efficacy in the management of several conditions and infliximab (IFX) is one of the most important drugs of the class. Some recent data have shown low rates of both persistence and adherence to several available biologics. OBJECTIVE: The objective of this study was to describe …
Resolution of Rectal Bleeding by Day 7 in Acute Severe Ulcerative Colitis Is Prognostic for Postdischarge Corticosteroid-Free Clinical Remission and Endoscopic Improvement
Publication Year: 2024 Source: Am J Gastroenterol PMID: 38775974 DOI: 10.14309/ajg.0000000000002860
This study assesses 2 different disease activity measures, the Modified Truelove Witts Severity Index and the partial Mayo score, in hospitalized patients with acute severe ulcerative colitis (UC) for prediction of postdischarge corticosteroid-free clinical remission and endoscopic improvement to help guide future considerations for disease activity assessment. In this post …
High-Dose Upadacitinib Therapy for Refractory Metastatic Crohn Disease
Publication Year: 2024 Source: JAMA Dermatol PMID: 38776111
No Abstract
Longitudinal and regional association between dietary factors and prevalence of Crohn's disease in Japan
Publication Year: 2024 Source: PLoS One PMID: 38776273
No Abstract
Activated HLA-DR+CD38+ Effector Th1/17 Cells Distinguish Crohn's Disease-associated Perianal Fistulas from Cryptoglandular Fistulas
Publication Year: 2024 Source: Inflamm Bowel Dis PMID: 38776553
No Abstract
Tedizolid phosphate alleviates DSS-induced ulcerative colitis by inhibiting senescence of cell and colon tissue through activating AMPK signaling pathway
Publication Year: 2024 Source: Int Immunopharmacol PMID: 38776849
No Abstract
Fraxinellone alleviates colitis-related intestinal fibrosis by blocking the circuit between PD-1(+) Th17 cells and fibroblasts
Publication Year: 2024 Source: Int Immunopharmacol PMID: 38776854 DOI: 10.1016/j.intimp.2024.112298
BACKGROUND: Excessive activation of colonic fibroblasts and differentiation of T helper 17 (Th17) cells are the key steps for intestinal fibrogenesis in the process of inflammatory bowel disease (IBD). Although both transforming growth factor-beta (TGF-beta)/Mothers Against Decapentaplegic Homolog (SMAD) 3-induced fibroblasts activation and interleukin (IL)-6/signal transducer and activator of transcription …
A genomic compendium of cultivated human gut fungi characterizes the gut mycobiome and its relevance to common diseases
Publication Year: 2024 Source: Cell PMID: 38776919 DOI: 10.1016/j.cell.2024.04.043
The gut fungal community represents an essential element of human health, yet its functional and metabolic potential remains insufficiently elucidated, largely due to the limited availability of reference genomes. To address this gap, we presented the cultivated gut fungi (CGF) catalog, encompassing 760 fungal genomes derived from the feces of …
Risk of Kidney Failure in Patients With Inflammatory Bowel Disease Undergoing Colectomy: A Nationwide Cohort Study
Publication Year: 2024 Source: Clin Gastroenterol Hepatol PMID: 38777172 DOI: 10.1016/j.cgh.2024.05.010
BACKGROUND & AIMS: Inflammatory bowel disease (IBD) is frequently accompanied by kidney complications. Potential triggers or subpopulations at high-risk of kidney problems are not well-elucidated. We hypothesized that surgical interventions, specifically colectomy, might in part explain this risk. METHODS: This study was a nationwide Swedish cohort study comprising 82,051 individuals …
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