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Navigating the complexities of drug development for inflammatory bowel disease
Publication Year: 2024 Source: Nat Rev Drug Discov PMID: 38778181 DOI: 10.1038/s41573-024-00953-0
Inflammatory bowel disease (IBD) - consisting of ulcerative colitis and Crohn's disease - is a complex, heterogeneous, immune-mediated inflammatory condition with a multifactorial aetiopathogenesis. Despite therapeutic advances in this arena, a ceiling effect has been reached with both single-agent monoclonal antibodies and advanced small molecules. Therefore, there is a need …
Morning light treatment for inflammatory bowel disease: a clinical trial
Publication Year: 2024 Source: BMC Gastroenterol PMID: 38778264 DOI: 10.1186/s12876-024-03263-2
BACKGROUND: Inflammatory bowel disease (IBD) affects over 3 million Americans and has a relapsing and remitting course with up to 30% of patients experiencing exacerbations each year despite the availability of immune targeted therapies. An urgent need exists to develop adjunctive treatment approaches to better manage IBD symptoms and disease …
Joint interprofessional education of pharmacy and dietetics undergraduates - a scoping review
Publication Year: 2024 Source: BMC Med Educ PMID: 38778278
No Abstract
Analysis of tofacitinib safety in ulcerative colitis from the completed global clinical developmental program up to 9.2 years of drug exposure
Publication Year: 2024 Source: United European Gastroenterol J PMID: 38778549
No Abstract
Dental service use among adults with incident type 2 diabetes, rheumatoid arthritis or inflammatory bowel disease
Publication Year: 2024 Source: Community Dent Oral Epidemiol PMID: 38778569 DOI: 10.1111/cdoe.12976
OBJECTIVES: It is not clear if or how the incidence of systemic conditions like type 2 diabetes mellitus (DM(2)), rheumatoid arthritis (RA) or inflammatory bowel disease (IBD) affects dental service utilization. Using nationwide Danish register data, the aim of this study was to analyse the use of dental services 7 …
Challenges in IBD Research 2024: Pragmatic Clinical Research
Publication Year: 2024 Source: Inflamm Bowel Dis PMID: 38778623 DOI: 10.1093/ibd/izae083
Pragmatic clinical research is 1 of the 5 focus areas of the Challenges in IBD Research 2024, a multidisciplinary effort by scientists, clinicians, patients, and funders to identify priorities for patient-centric research. This summary provides a comprehensive overview of current gaps in inflammatory bowel disease (IBD) clinical research and actionable …
Challenges in IBD Research 2024: Environmental Triggers
Publication Year: 2024 Source: Inflamm Bowel Dis PMID: 38778624 DOI: 10.1093/ibd/izae085
No Abstract
Challenges in IBD Research 2024: Novel Technologies
Publication Year: 2024 Source: Inflamm Bowel Dis PMID: 38778625 DOI: 10.1093/ibd/izae082
Novel technology is one of the five focus areas of the Challenges in Inflammatory Bowel Disease (IBD) Research 2024 document. Building off the Challenges in IBD Research 2019 document, the Foundation aims to provide a comprehensive overview of current gaps in IBD research and deliver actionable approaches to address them …
Overview to Challenges in IBD 2024-2029
Publication Year: 2024 Source: Inflamm Bowel Dis PMID: 38778626 DOI: 10.1093/ibd/izae092
The mission of the Crohn's & Colitis Foundation is to cure Crohn's disease and ulcerative colitis and to improve the quality of lives of patients living with these diseases-in other words, to care and cure. To achieve these missions, there is a need to identify and prioritize research gaps and …
Challenges in IBD Research 2024: Preclinical Human IBD Mechanisms
Publication Year: 2024 Source: Inflamm Bowel Dis PMID: 38778627 DOI: 10.1093/ibd/izae081
Preclinical human inflammatory bowel disease (IBD) mechanisms is one of 5 focus areas of the Challenges in IBD Research 2024 document, which also includes environmental triggers, novel technologies, precision medicine, and pragmatic clinical research. Herein, we provide a comprehensive overview of current gaps in inflammatory bowel diseases research that relate …
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