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Exploring shared molecular signatures and regulatory mechanisms in nonalcoholic steatohepatitis and inflammatory bowel disease using integrative bioinformatics analysis
Publication Year: 2024 Source: Sci Rep PMID: 38802459 DOI: 10.1038/s41598-024-62310-w
The co-existence of inflammatory bowel disease (IBD) and non-alcoholic steatohepatitis (NASH) has raised interest in identifying shared molecular mechanisms and potential therapeutic targets. However, the relationship between these two diseases remains unclear and effective medical treatments are still lacking. Through the bioinformatics analysis in this study, 116 shared differentially expressed …
Disease-specific alterations in central fear network engagement during acquisition and extinction of conditioned interoceptive fear in inflammatory bowel disease
Publication Year: 2024 Source: Mol Psychiatry PMID: 38802508 DOI: 10.1038/s41380-024-02612-7
Interoceptive fear, which is shaped by associative threat learning and memory processes, plays a central role in abnormal interoception and psychiatric comorbidity in conditions of the gut-brain axis. Although animal and human studies support that acute inflammation induces brain alterations in the central fear network, mechanistic knowledge in patients with …
Genome-wide cross-disease analyses highlight causality and shared biological pathways of type 2 diabetes with gastrointestinal disorders
Publication Year: 2024 Source: Commun Biol PMID: 38802514 DOI: 10.1038/s42003-024-06333-z
Studies suggest links between diabetes and gastrointestinal (GI) traits; however, their underlying biological mechanisms remain unclear. Here, we comprehensively assess the genetic relationship between type 2 diabetes (T2D) and GI disorders. Our study demonstrates a significant positive global genetic correlation of T2D with peptic ulcer disease (PUD), irritable bowel syndrome …
[Advances in Mendelian randomization studies on autism spectrum disorder]
Publication Year: 2024 Source: Zhongguo Dang Dai Er Ke Za Zhi PMID: 38802917
No Abstract
Factors associated with decreased ovarian reserve in Crohn's disease: A systematic review and meta-analysis
Publication Year: 2024 Source: Acta Obstet Gynecol Scand PMID: 38803058
No Abstract
Total flavone of Abelmoschus manihot regulates autophagy through the AMPK/mTOR signaling pathway to treat intestinal fibrosis in Crohn's disease
Publication Year: 2024 Source: J Gastroenterol Hepatol PMID: 38803139
No Abstract
The Therapeutic Target of IBD and the Mechanism of Dipyridamole in Treating IBD Explored by Geo Gene Chips, Network Pharmacology, and Molecular Docking
Publication Year: 2024 Source: Endocr Metab Immune Disord Drug Targets PMID: 38803168 DOI: 10.2174/0118715303287122240429092014
BACKGROUND AND AIMS: Inflammatory Bowel Disease (IBD) is a refractory disease with repeated attacks, and there is no accurate treatment target at present. Dipyridamole, a phosphodiesterase (PDE) inhibitor, has been proven to be an effective treatment for IBD in a pilot study. This study explored the therapeutic target of IBD …
miRNA-21, an Important Regulator of Autoimmune Diseases
Publication Year: 2024 Source: Curr Mol Med PMID: 38803177 DOI: 10.2174/0115665240290075240514164601
No Abstract
Early diagnosis and treatment of perianal Crohn's disease in a 1-year-old infant: Case report and review of literature
Publication Year: 2024 Source: Clin Case Rep PMID: 38803326
No Abstract
Studying the cellular basis of small bowel enteropathy using high-parameter flow cytometry in mouse models of primary antibody deficiency
Publication Year: 2024 Source: Front Immunol PMID: 38803492
No Abstract
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