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Cannabis Use in Patients With Inflammatory Bowel Disease Following Legalization of Cannabis in Canada
Publication Year: 2024 Source: Crohns Colitis 360 PMID: 38800569 DOI: 10.1093/crocol/otae031
BACKGROUND: Cannabis is used by patients with Crohn's disease (CD) and ulcerative colitis (UC) as an alternative to, or in combination with, conventional therapies to treat symptoms such as abdominal pain, poor sleep, and reduced appetite. The clinical efficacy of cannabis for these disorders is controversial, with some studies showing …
Mesenchymal Stromal Cells: New Generation Treatment of Inflammatory Bowel Disease
Publication Year: 2024 Source: J Inflamm Res PMID: 38800593 DOI: 10.2147/JIR.S458103
Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract, which has a high recurrence rate and is incurable due to a lack of effective treatment. Mesenchymal stromal cells (MSCs) are a class of pluripotent stem cells that have recently received a lot of attention due to …
Ustekinumab in paediatric patients with moderately to severely active Crohn's disease: UniStar study long-term extension results
Publication Year: 2024 Source: J Pediatr Gastroenterol Nutr PMID: 38801079 DOI: 10.1002/jpn3.12252
OBJECTIVES: To assess the efficacy, safety, immunogenicity, and pharmacokinetics through 240 weeks of ustekinumab treatment in paediatric patients from the long-term extension (LTE) of the phase 1, double-blind UniStar trial. METHODS: Paediatric patients with moderately to severely active Crohn's disease (CD) were randomised 1:1 and stratified by body weight (<40 …
Diverting ileostomy in benign colorectal surgery: the real clinical cost analysis
Publication Year: 2024 Source: Updates Surg PMID: 38801603 DOI: 10.1007/s13304-024-01879-3
There are three types of complications stoma related: ones related to its construction, ones related to its function and related to closure. The aim of this study was to assess the risk of complications related to the stoma presence and to identificate variables related to complications. We conducted a retrospective …
Effects of Pistacia genus on gastrointestinal tract disorders: A systematic and comprehensive review
Publication Year: 2024 Source: Fitoterapia PMID: 38801894
No Abstract
Casearia sylvestris var. lingua (Càmbess.) Eichler leaves aqueous extract improves colon inflammation through mucogenic, antioxidant and anti-inflammatory actions in TNBS- induced IBD rats
Publication Year: 2024 Source: J Ethnopharmacol PMID: 38801913
No Abstract
Effect of hydrogel drug delivery system for treating ulcerative colitis: A preclinical meta-analysis
Publication Year: 2024 Source: Int J Pharm PMID: 38802026
No Abstract
Intraintestinal Heterogeneity of Drug Target Expression in Inflammatory Bowel Disease
Publication Year: 2024 Source: Ann Clin Lab Sci PMID: 38802165
OBJECTIVE: There has been no significant improvement in remission rate in inflammatory bowel disease (IBD) despite several new drugs being introduced in the past two decades. Post-treatment biopsies sometimes show histologic healing in some areas of the intestine while other areas within the same intestine continue to show active inflammation. …
Associations between prior healthcare use, time to diagnosis, and clinical outcomes in inflammatory bowel disease: a nationally representative population-based cohort study
Publication Year: 2024 Source: BMJ Open Gastroenterol PMID: 38802264 DOI: 10.1136/bmjgast-2024-001371
BACKGROUND: Timely diagnosis and treatment of inflammatory bowel disease (IBD) may improve clinical outcomes. OBJECTIVE: Examine associations between time to diagnosis, patterns of prior healthcare use, and clinical outcomes in IBD. DESIGN: Using the Clinical Practice Research Datalink we identified incident cases of Crohn's disease (CD) and ulcerative colitis (UC), …
Current understanding of the interplay between extracellular matrix remodelling and gut permeability in health and disease
Publication Year: 2024 Source: Cell Death Discov PMID: 38802341 DOI: 10.1038/s41420-024-02015-1
The intestinal wall represents an interactive network regulated by the intestinal epithelium, extracellular matrix (ECM) and mesenchymal compartment. Under healthy physiological conditions, the epithelium undergoes constant renewal and forms an integral and selective barrier. Following damage, the healthy epithelium is restored via a series of signalling pathways that result in …
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