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The role of upper gastrointestinal endoscopy in the diagnosis of pediatric inflammatory bowel disease

Publication Year: 2024 Source: Am J Clin Pathol PMID: 38934570 DOI: 10.1093/ajcp/aqae074

OBJECTIVES: Upper gastrointestinal (UGI) tract involvement is frequently reported in pediatric Crohn disease (CD) and ulcerative colitis (UC). Aside from granulomas, most findings are nonspecific. The aims of this study were to review the prevalence of UGI tract findings in pediatric patients with CD or UC at diagnosis and to …

Lemann Index for assessing bowel damage in Crohn's disease: a real world study

Publication Year: 2024 Source: J Crohns Colitis PMID: 38935558 DOI: 10.1093/ecco-jcc/jjae102

BACKGROUND & AIMS: The Lemann Index (LI), an endpoint to measure cumulative structural bowel damage in Crohn's disease (CD), has been recently updated and validated. We applied this to investigate predictors of bowel damage in a real-world cohort. METHODS: We performed a retrospective study (2008-2022) involving two tertiary referral IBD …

Preclinical proof of principle for orally delivered Th17 antagonist miniproteins

Publication Year: 2024 Source: Cell PMID: 38936360

No Abstract

Lipid signature associated with chronic colon inflammation reveals a dysregulation in colonocyte differentiation process

Publication Year: 2024 Source: Biochim Biophys Acta Mol Cell Biol Lipids PMID: 38936507 DOI: 10.1016/j.bbalip.2024.159528

Inflammatory Bowel Disease (IBD) comprises a heterogeneous group of chronic inflammatory conditions of the gastrointestinal tract that include ulcerative colitis (UC) and Crohn's disease. Although the etiology is not well understood, IBD is characterized by a loss of the normal epithelium homeostasis that disrupts the intestinal barrier of these patients. …

Impaired neutrophil migration underpins host susceptibility to infectious colitis

Publication Year: 2024 Source: Mucosal Immunol PMID: 38936619

No Abstract

Bariatric surgery in inflammatory bowel disease: a comparative analysis of 450,000 patients

Publication Year: 2024 Source: Surg Obes Relat Dis PMID: 38937216 DOI: 10.1016/j.soard.2024.05.008

BACKGROUND: Studies were conducted to investigate the outcomes of bariatric surgery (BS) among inflammatory bowel disease (IBD) patients. OBJECTIVES: We aimed to analyze previous literature, comparing the outcomes of BS between IBD and non-IBD patients. SETTING: Not applicable. METHODS: PubMed, Scopus, and Web of Science were searched on 25/9/2023 for …

ETS2 drives IBD

Publication Year: 2024 Source: Nat Rev Drug Discov PMID: 38937615 DOI: 10.1038/d41573-024-00110-7

No Abstract

Unexpected variation in outcomes following total (procto)colectomies for ulcerative colitis in New South Wales, Australia: a population-based 19-year linked-data study

Publication Year: 2024 Source: Colorectal Dis PMID: 38937922

No Abstract

Use of glucagon-like peptide-1 receptor agonists for type 2 diabetes mellitus and outcomes of inflammatory bowel disease

Publication Year: 2024 Source: Aliment Pharmacol Ther PMID: 38938071 DOI: 10.1111/apt.18138

BACKGROUND: Glucagon-like peptide-1 receptor agonists (GLP-1RA) show anti-inflammatory properties. AIM: To evaluate their clinical impact on inflammatory bowel disease (IBD) outcomes. METHODS: Retrospective cohort study utilising the TriNetX database comparing IBD-specific outcomes in patients with ulcerative colitis (UC) or Crohn's disease (CD) and type 2 diabetes mellitus (T2DM) on GLP-1RA …

Inflammatory bowel disease and rheumatoid arthritis share a common genetic structure

Publication Year: 2024 Source: Front Immunol PMID: 38938570 DOI: 10.3389/fimmu.2024.1359857

BACKGROUND: The comorbidity rate of inflammatory bowel disease (IBD) and rheumatoid arthritis (RA) is high; nevertheless, the reasons behind this high rate remain unclear. Their similar genetic makeup probably contributes to this comorbidity. METHODS: Based on data obtained from the genome-wide association study of IBD and RA, we first assessed …

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