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Possible poor prognosis in younger-onset Crohn's disease-associated anorectal cancer: A subanalysis of the Nationwide Japanese study
Publication Year: 2024 Source: Ann Gastroenterol Surg PMID: 38957565
No Abstract
Tuberculosis and Immune Reconstitution Inflammatory Syndrome in Patients With Inflammatory Bowel Disease and Anti-TNFα Treatment: Insights From a French Multicenter Study and Systematic Literature Review With Emphasis on Paradoxical Anti-TNFα Resumption
Publication Year: 2024 Source: Open Forum Infect Dis PMID: 38957691 DOI: 10.1093/ofid/ofae327
BACKGROUND: The advent of anti-tumor necrosis factor alpha (anti-TNFalpha) has revolutionized the treatment of inflammatory bowel disease (IBD). However, susceptibility to active tuberculosis (TB) is associated with this therapy and requires its discontinuation. The risk of immune reconstitution inflammatory syndrome (IRIS) in this population is poorly understood, as is the …
Disruption of intestinal oxygen balance in acute colitis alters the gut microbiome
Publication Year: 2024 Source: Gut Microbes PMID: 38958039
No Abstract
Exosomes derived from cancer cells relieve inflammatory bowel disease in mice
Publication Year: 2024 Source: J Drug Target PMID: 38958251 DOI: 10.1080/1061186X.2024.2369876
Exosome therapy has garnered significant attention due to its natural delivery capabilities, low toxicity, high biocompatibility, and potential for personalised treatment through engineering modifications. Recent studies have highlighted the ability of tumour cell-derived exosomes (TDEs) to interact with immune cells or modify the immune microenvironment to suppress host immune responses, …
Novel infantile presentations of chronic granulomatous disease
Publication Year: 2024 Source: Pediatr Allergy Immunol PMID: 38958540
No Abstract
Exploring regulatory mechanisms on miRNAs and their implications in inflammation-related diseases
Publication Year: 2024 Source: Clin Exp Med PMID: 38958690
No Abstract
Epithelial Membrane Protein 2 (EMP2) Blockade Attenuates Pathological Neovascularization in Murine Oxygen-Induced Retinopathy
Publication Year: 2024 Source: Invest Ophthalmol Vis Sci PMID: 38958972
No Abstract
Letter to the editor: Real-world evidence of combined treatment of biologics and exclusive enteral nutrition in patients with ileum-dominant Crohn's disease: A multicenter study
Publication Year: 2024 Source: Clin Nutr ESPEN PMID: 38959107
No Abstract
Discovery of a Series of 4-Amide-thiophene-2-carboxyl Derivatives as Highly Potent P2Y(14) Receptor Antagonists for Inflammatory Bowel Disease Treatment
Publication Year: 2024 Source: J Med Chem PMID: 38959216 DOI: 10.1021/acs.jmedchem.4c00699
The P2Y(14) receptor has been proven to be a potential target for IBD. Herein, we designed and synthesized a series of 4-amide-thiophene-2-carboxyl derivatives as novel potent P2Y(14) receptor antagonists based on the scaffold hopping strategy. The optimized compound 39 (5-((5-fluoropyridin-2-yl)oxy)-4-(4-methylbenzamido)thiophene-2-carboxylic acid) exhibited subnanomolar antagonistic activity (IC(50): 0.40 nM). Moreover, compound …
The First Discovery of Marine Polyoxygenated Cembranolides as Potential Agents for the Treatment of Ulcerative Colitis
Publication Year: 2024 Source: J Med Chem PMID: 38959374
No Abstract
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