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Helminth-derived metabolites induce tolerogenic functional, metabolic, and transcriptional signatures in dendritic cells that attenuate experimental colitis
Publication Year: 2024 Source: bioRxiv PMID: 39211070 DOI: 10.1101/2023.01.26.525718
Inflammatory bowel diseases (IBD) are chronic inflammatory diseases in which abdominal pain, bloody diarrhea, weight loss, and fatigue collectively result in diminished quality of patient life. The disappearance of intestinal helminth infections in Western societies is associated with an increased prevalence of IBD and other immune-mediated inflammatory diseases. Evidence indicates …
Treatment Pathways in Patients With Crohn's Disease and Ulcerative Colitis: Understanding the Road to Advanced Therapy
Publication Year: 2024 Source: Crohns Colitis 360 PMID: 39211396
No Abstract
Elucidating the genetic relationship between ulcerative colitis and diabetic kidney disease: a bidirectional Mendelian randomization study
Publication Year: 2024 Source: Front Endocrinol (Lausanne) PMID: 39211444
No Abstract
PepT1-targeted nanodrug based on co-assembly of anti-inflammatory peptide and immunosuppressant for combined treatment of acute and chronic DSS-induced ColitiS
Publication Year: 2024 Source: Front Pharmacol PMID: 39211778 DOI: 10.3389/fphar.2024.1442876
INTRODUCTION: Inflammatory bowel disease (IBD), as a chronic and recurrent inflammatory bowel diseases with limited therapeutic outcomes, is characterized by immune disorders and intestinal barrier dysfunction. Currently, the most medications used to cure IBD in clinic just temporarily induce and maintain remission with poor response rates and limited outcomes. Therefore, …
Patterns of Immune Dysregulation in Bipolar Disorder
Publication Year: 2024 Source: medRxiv PMID: 39211848
No Abstract
A metabolic constraint in the kynurenine pathway drives mucosal inflammation in IBD
Publication Year: 2024 Source: medRxiv PMID: 39211892 DOI: 10.1101/2024.08.08.24311598
Inflammatory bowel disease (IBD) is associated with perturbed metabolism of the essential amino acid tryptophan (Trp). Whether increased degradation of Trp directly fuels mucosal inflammation or acts as a compensatory attempt to restore cellular energy levels via de-novo nicotinamide adenine dinucleotide (NAD (+) ) synthesis is not understood. Employing a …
Autoimmune Sequelae After Delta or Omicron Variant SARS-CoV-2 Infection in a Highly Vaccinated Cohort
Publication Year: 2024 Source: JAMA Netw Open PMID: 39212988
No Abstract
Real-world effectiveness and safety of advanced therapies for the treatment of moderate-to-severe ulcerative colitis: Evidence from a systematic literature review
Publication Year: 2024 Source: J Manag Care Spec Pharm PMID: 39213145
No Abstract
Case-control study of IL23R rs76418789 polymorphism, smoking, and ulcerative colitis in Japan
Publication Year: 2024 Source: Cytokine PMID: 39213891
No Abstract
Corrigendum to "Visualisation of Mycobacterium avium subsp. paratuberculosis in cultured cells, infected sheep and human tissue sections using fluorescent in situ hybridization (FISH)" [Journal of Microbiological Methods 224 (2024) 107001]
Publication Year: 2024 Source: J Microbiol Methods PMID: 39214850 DOI: 10.1016/j.mimet.2024.107024
No Abstract
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