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The ameliorating potential of Citrus aurantifolia peel extract in the 2, 4, 6-trinitrobenzenesulfonic acid model of mice colitis
Publication Year: 2024 Source: Med J Malaysia PMID: 39215414
No Abstract
Oral Microto-Nano Genome-Editing System Enabling Targeted Delivery and Conditional Activation of CRISPR-Cas9 for Gene Therapy of Inflammatory Bowel Disease
Publication Year: 2024 Source: ACS Nano PMID: 39215751 DOI: 10.1021/acsnano.4c07750
The potent CRISPR-Cas9 technology can correct genes in human mutated cells to achieve the treatment of multiple diseases, but it lacks safe and effective delivery systems. Herein, we proposed an oral microto-nano genome-editing system aiming at the enteric excessive level of TNF-alpha for specific gene therapy of inflammatory bowel disease …
Inflammatory bowel disease genomics, transcriptomics, proteomics and metagenomics meet artificial intelligence
Publication Year: 2024 Source: United European Gastroenterol J PMID: 39215755 DOI: 10.1002/ueg2.12655
Various extrinsic and intrinsic factors such as drug exposures, antibiotic treatments, smoking, lifestyle, genetics, immune responses, and the gut microbiome characterize ulcerative colitis and Crohn's disease, collectively called inflammatory bowel disease (IBD). All these factors contribute to the complexity and heterogeneity of the disease etiology and pathogenesis leading to major …
Natural History and Longitudinal Outcomes of Patients with Mild-to-Moderate Ulcerative Proctitis or Ulcerative Proctosigmoiditis: A Single-Center, Retrospective Study
Publication Year: 2024 Source: Dig Dis Sci PMID: 39215867
No Abstract
Preventing Recurrence of Crohn's Disease Post-Ileocaecal Surgery in Paediatric Patients: A Therapy Guide Based on Systematic Review of the Evidence
Publication Year: 2024 Source: Paediatr Drugs PMID: 39215954
No Abstract
Low Placental Transfer Rates of Risankizumab Among Pregnant Women With Inflammatory Bowel Disease
Publication Year: 2024 Source: Inflamm Bowel Dis PMID: 39216079
No Abstract
Paeoniflorin alleviates DSS-induced ulcerative colitis by suppressing inflammation, oxidative stress, and apoptosis via regulating serum metabolites and inhibiting CDC42/JNK signaling pathway
Publication Year: 2024 Source: Int Immunopharmacol PMID: 39216118
No Abstract
Gut bacterial type III secretion systems aggravate colitis in mice and serve as biomarkers of Crohn's disease
Publication Year: 2024 Source: EBioMedicine PMID: 39216231
No Abstract
Co-amorphous systems of sulfasalazine with matrine-type alkaloids: Enhanced solubility behaviors and synergistic therapeutic potential
Publication Year: 2024 Source: Eur J Pharm Biopharm PMID: 39216557 DOI: 10.1016/j.ejpb.2024.114475
Sulfasalazine (SULF), a sulfonamide antibiotic, has been utilized in the treatment of rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) since its discovery. However, its poor water solubility causes the high daily doses (1---3 g) for patients, which may lead to the intolerable toxic and side effects for their lifelong …
Epithelial Piezo1 deletion ameliorates intestinal barrier damage by regulating ferroptosis in ulcerative colitis
Publication Year: 2024 Source: Free Radic Biol Med PMID: 39216559
No Abstract
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