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Structural basis for the full and partial agonist activities of retinoid X receptor α ligands with an iso-butoxy and an isopropyl group
Publication Year: 2024 Source: Biochem Biophys Res Commun PMID: 39241622
No Abstract
Loss of DOCK2 potentiates Inflammatory Bowel Disease-associated colorectal cancer via immune dysfunction and IFNγ induction of IDO1 expression
Publication Year: 2024 Source: Oncogene PMID: 39242821 DOI: 10.1038/s41388-024-03135-9
Inflammatory Bowel Disease-associated colorectal cancer (IBD-CRC) is a known and serious complication of Inflammatory Bowel Disease (IBD) affecting the colon. However, relatively little is known about the pathogenesis of IBD-associated colorectal cancer in comparison with its sporadic cancer counterpart. Here, we investigated the function of Dock2, a gene mutated in …
Global, regional, and national burden of inflammatory bowel disease, 1990-2021: Insights from the global burden of disease 2021
Publication Year: 2024 Source: Int J Colorectal Dis PMID: 39243331 DOI: 10.1007/s00384-024-04711-x
PURPOSE: The prevalence of inflammatory bowel disease (IBD) is on the rise worldwide. We utilizes data from the Global Burden of Diseases (GBD) 2021 to analyze the national-level burden of IBD, trends in disease incidence, and epidemiological characteristics. METHODS: Detailed information on IBD was gathered from 204 countries and territories …
Exploring the influence of non-coding RNAs on NF-κB signaling pathway regulation in ulcerative colitis
Publication Year: 2024 Source: Biomed Pharmacother PMID: 39243424
No Abstract
Systemic Factors Affecting Prognosis and Outcomes in Periodontal Disease
Publication Year: 2024 Source: Dent Clin North Am PMID: 39244245
No Abstract
Inadvertent live vaccine administration in adult patients with inflammatory bowel disease on immunosuppressive therapy
Publication Year: 2024 Source: Vaccine PMID: 39244424 DOI: 10.1016/j.vaccine.2024.126319
Live vaccines are contraindicated in patients on immunosuppressive therapy. We conducted a retrospective study evaluating the administration of a live vaccine in patients with IBD on immunosuppressive therapy. The primary outcome was to determine clinical or disseminated disease episodes within three months of vaccine administration in patients who inadvertently received …
Differences in Prognosis and Recurrence Patterns Between Ulcerative Colitis-Associated Colorectal Cancer and Sporadic Colorectal Cancer: A Matched-Pair Analysis
Publication Year: 2024 Source: Ann Surg Oncol PMID: 39244515
No Abstract
Dysregulated NOX1-NOS2 activity as hallmark of ileitis in mice
Publication Year: 2024 Source: Mucosal Immunol PMID: 39245144 DOI: 10.1016/j.mucimm.2024.08.012
Inflammation of the ileum, or ileitis, is commonly caused by Crohn's disease (CD) but can also accompany ulcerative colitis (backwash ileitis), infections or drug-related damage. Oxidative tissue injury triggered by reactive oxygen species (ROS) is considered part of the ileitis etiology. However, not only elevated ROS but also permanently decreased …
Nanofiber-boosted retrograded starch/pectin microparticles for targeted 5-Aminosalicylic acid delivery in inflammatory bowel disease: In vitro and in vivo non-toxicity evaluation
Publication Year: 2024 Source: Carbohydr Polym PMID: 39245532 DOI: 10.1016/j.carbpol.2024.122647
Incorporating 5-aminosalicylic acid (5-ASA) into a colon-specific carrier is crucial for treating inflammatory bowel diseases (IBD), as it enhances therapeutic efficacy, targets the affected regions directly, and minimizes side effects. This study evaluated the impact of incorporating cellulose nanofibers (CNF) on the in vitro and in vivo biological performance of …
gwid: an R package and Shiny application for Genome-Wide analysis of IBD data
Publication Year: 2024 Source: Bioinform Adv PMID: 39246385 DOI: 10.1093/bioadv/vbae115
SUMMARY: Genome-wide identity by descent (gwid) is an R package developed for the analysis of identity-by-descent (IBD) data pertaining to dichotomous traits. This package offers a set of tools to assess differential IBD levels for the two states of a binary trait, yielding informative and meaningful results. Furthermore, it provides …
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